Abcc1 ATP-binding cassette, sub-family C member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abcc1provided by MGI
Official Full Name: ATP-binding cassette, sub-family C member 1provided by MGI
Primary source: MGI:MGI:102676
See related: Ensembl:ENSMUSG00000023088 AllianceGenome:MGI:102676
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MRP; Mrp1; Mdrap; Abcc1a; Abcc1b
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein plays an essential role in the defense against toxic compounds and serves as the major high-affinity transporter of leukotriene C4. The encoded protein may also play an essential role in steroid hormone homeostasis as a transporter for steroid hormones and their metabolites. [provided by RefSeq, Nov 2011]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 11.9), genital fat pad adult (RPKM 10.8) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 9.75 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (14179317..14292743)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (14361453..14474878)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP.
Title: ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP.
Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione.
Title: Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione.
ABCC1 regulates cocaine-associated memory, spine plasticity and GluA1 and GluA2 surface expression.
Title: ABCC1 regulates cocaine-associated memory, spine plasticity and GluA1 and GluA2 surface expression.
Infected Mrp1 knockout mice show decreased iNKT cell responses to antigens from Streptococcus pneumoniae and were associated with increased mortality.
Title: Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae.
The authors conclude that MRP1 assists in depression of polymorphonuclear cell (PMN) migration by effluxing a molecule that inhibits the proinflammatory effects of MRP2 activity.
Title: Transporters MRP1 and MRP2 Regulate Opposing Inflammatory Signals To Control Transepithelial Neutrophil Migration during Streptococcus pneumoniae Lung Infection.
Mrp1 protects cardiac myocytes and fibroblasts against doxorubicin-induced toxicity, potentially by regulating extracellular redox states.
Title: Loss of Mrp1 Potentiates Doxorubicin-Induced Cytotoxicity in Neonatal Mouse Cardiomyocytes and Cardiac Fibroblasts.
Loss of ABCC1 expression is associated with neonatal hyperbilirubinemia.
Title: Modulation of bilirubin neurotoxicity by the Abcb1 transporter in the Ugt1-/- lethal mouse model of neonatal hyperbilirubinemia.
Data, including data from studies in knockout mice, suggest that Mrp1 is involved in development of vascular endothelial dysfunction in diabetic angiopathy; Mrp1 appears to be required for oxidative stress in endothelial cells due to hyperglycemia.
Title: Multidrug resistance associated protein-1 (MRP1) deficiency attenuates endothelial dysfunction in diabetes.
Oxidant-enriched Tumorigenic Endothelial Cells (EOMA) cells survive a heavy oxidant burden by rapid efflux of GSSG, which is lethal if trapped within the cell. A hyperactive MRP-1 system for GSSG efflux acts as a critical survival factor for these cells, making it a potential target for EOMA therapeutics.
Title: Multidrug Resistance-associated Protein-1 (MRP-1)-dependent Glutathione Disulfide (GSSG) Efflux as a Critical Survival Factor for Oxidant-enriched Tumorigenic Endothelial Cells.
P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier
Title: Blood-brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P-glycoprotein on a novel verapamil influx carrier.

Submit: New GeneRIF Correction See all GeneRIFs (41)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D16Ertd780e (e-PCR), detects polymorphism
- UniSTS:167204

Abcc1 (e-PCR), detects polymorphism
- UniSTS:532532

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ABC-type glutathione S-conjugate transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ABC-type transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type vitamin B12 transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ABC-type vitamin B12 transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type xenobiotic transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ABC-type xenobiotic transporter activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled lipid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables carboxylic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables efflux transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables glutathione transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glutathione transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables xenobiotic transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in carboxylic acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amyloid-beta	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cobalamin transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cyclic nucleotide transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cyclic nucleotide transport	ISO Inferred from Sequence Orthology more info
involved_in export across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in glial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in glutathione transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in leukotriene transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in phospholipid efflux	ISO Inferred from Sequence Orthology more info
involved_in phospholipid translocation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cellular response to drug	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in sphingolipid translocation	ISO Inferred from Sequence Orthology more info
involved_in transepithelial transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basal plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: multidrug resistance-associated protein 1

Names: ATP-binding cassette, sub-family C (CFTR/MRP), member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1a; ATP-binding cassette, sub-family C (CFTR/MRP), member 1b; LTC4 transporter; glutathione-S-conjugate-translocating ATPase ABCC1; leukotriene C(4) transporter; multiple drug resistance-associated protein

NP_001412107.1

EC 7.6.2.2

EC 7.6.2.3

NP_032602.1

EC 7.6.2.2

EC 7.6.2.3

XP_017172377.1

EC 7.6.2.2

EC 7.6.2.3

XP_036015706.1

EC 7.6.2.2

EC 7.6.2.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001425178.1 → NP_001412107.1 multidrug resistance-associated protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC154265
NM_008576.4 → NP_032602.1 multidrug resistance-associated protein 1 isoform 1

See identical proteins and their annotated locations for NP_032602.1

Status: VALIDATED

Source sequence(s)

AC154265

Consensus CDS

CCDS37264.1

UniProtKB/Swiss-Prot

O35379

UniProtKB/TrEMBL

A5D6P3

Related

ENSMUSP00000097743.4, ENSMUST00000100167.10

Conserved Domains (1) summary

TIGR00957
Location:7 → 1527

MRP_assoc_pro; multi drug resistance-associated protein (MRP)

RNA

NR_189144.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC154265

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

14179317..14292743

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017316888.2 → XP_017172377.1 multidrug resistance-associated protein 1 isoform X2

UniProtKB/TrEMBL

Q3UDM1

Related

ENSMUSP00000116714.2, ENSMUST00000130671.8

Conserved Domains (1) summary

TIGR00957
Location:7 → 773

MRP_assoc_pro; multi drug resistance-associated protein (MRP)
XM_036159813.1 → XP_036015706.1 multidrug resistance-associated protein 1 isoform X3

UniProtKB/TrEMBL

Q8C7V6

Conserved Domains (1) summary

TIGR00957
Location:1 → 787

MRP_assoc_pro; multi drug resistance-associated protein (MRP)