Mrtfb myocardin related transcription factor B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mrtfbprovided by MGI
Official Full Name: myocardin related transcription factor Bprovided by MGI
Primary source: MGI:MGI:3050795
See related: Ensembl:ENSMUSG00000009569 AllianceGenome:MGI:3050795
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mkl2; Gt4-1; MRTF-B; SOLOIST; mKIAA1243
Summary: Enables DNA-binding transcription factor activity; actin binding activity; and transcription coactivator activity. Acts upstream of or within several processes, including animal organ development; generation of neurons; and smooth muscle cell differentiation. Located in cytoplasm. Is expressed in cardiovascular system; genitourinary system; liver; septum transversum; and yolk sac. Orthologous to human MRTFB (myocardin related transcription factor B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 9.3), cortex adult (RPKM 9.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 9.24 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (13073913..13235393)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (13256056..13417529)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of SOLOIST/MRTFB i4, a novel neuronal isoform of the mouse serum response factor coactivator myocardin-related transcription factor-B, negatively regulates dendritic complexity in cortical neurons.
Title: Expression of SOLOIST/MRTFB i4, a novel neuronal isoform of the mouse serum response factor coactivator myocardin-related transcription factor-B, negatively regulates dendritic complexity in cortical neurons.
Dynamic subcellular localization and transcription activity of the SRF cofactor MKL2 in the striatum are regulated by MAPK.
Title: Dynamic subcellular localization and transcription activity of the SRF cofactor MKL2 in the striatum are regulated by MAPK.
Exercise-dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF-SRF signalling.
Title: Exercise-dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF-SRF signalling.
Knockout of Mrtfb in mouse intestine significantly enhances tumor development in Apc mutant mice.
Title: MRTFB suppresses colorectal cancer development through regulating SPDL1 and MCAM.
MRTF-A/B control an acute mechanosensitive signaling circuit that coordinates cross-talk between the actin and microtubule cytoskeleton and maintains intercalated disc integrity and cardiomyocyte homeostasis in heart disease.
Title: Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors Is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy.
In conclusion, SRF andMKL1/MKL2 are essential for postnatal podocyte structure and function, likely through the maintenance of a normal actin cytoskeleton.
Title: Serum Response Factor Is Essential for Maintenance of Podocyte Structure and Function.
BRG1 promotes transcription of endothelial Mrtfa and Mrtfb, which elevates expression of SRF and SRF target genes that establish embryonic capillary integrity.
Title: BRG1 (Brahma-Related Gene 1) Promotes Endothelial Mrtf Transcription to Establish Embryonic Capillary Integrity.
MRTF-A/B depletion results in an increase in the cell surface expression of ICAM-1 and interactions between HAoECs and leukocytes
Title: A novel inhibitory mechanism of MRTF-A/B on the ICAM-1 gene expression in vascular endothelial cells.
Either MRTF-A or MRTF-B is dispensable for cardiac development, whereas deletion of both causes a spectrum of abnormalities ranging from reduced cardiac contractility and adult onset heart failure to neonatal lethality accompanied by sarcomere disarray.
Title: Myocardin-related transcription factors are required for cardiac development and function.
These results identify SRF and its MRTF cofactors as major transcriptional regulators of endothelial cell junctional stability, guaranteeing physiological functions of the cerebral microvasculature.
Title: Endothelial depletion of murine SRF/MRTF provokes intracerebral hemorrhagic stroke.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (4) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:225160

NoName (e-PCR)
- UniSTS:548525

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic organ development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of striated muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smooth muscle cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vascular associated smooth muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: myocardin-related transcription factor B

Names: MKL/myocardin-like 2; MKL/myocardin-like protein 2; gene trap insertion site 4-1; megakaryoblastic leukemia 2; myocardial related transcription factor B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122667.2 → NP_001116139.1 myocardin-related transcription factor B isoform 3

See identical proteins and their annotated locations for NP_001116139.1

Status: VALIDATED

Source sequence(s)

AC160961, AC163640

Consensus CDS

CCDS49768.1

UniProtKB/TrEMBL

A3KMF2, G3X8R8

Related

ENSMUSP00000009713.8, ENSMUST00000009713.14

Conserved Domains (5) summary

PHA03247
Location:197 → 321

PHA03247; large tegument protein UL36; Provisional

pfam02037
Location:394 → 427

SAP; SAP domain

pfam02755
Location:141 → 163

RPEL; RPEL repeat

cl20817
Location:565 → 605

GBP_C; Guanylate-binding protein, C-terminal domain

cl29414
Location:52 → 76

RPEL; RPEL repeat
NM_153588.3 → NP_705816.2 myocardin-related transcription factor B isoform 1

See identical proteins and their annotated locations for NP_705816.2

Status: VALIDATED

Source sequence(s)

AC163640, AF532598, CJ126058, CK639342

Consensus CDS

CCDS37258.1

UniProtKB/Swiss-Prot

P59759

UniProtKB/TrEMBL

Q5DTZ3

Related

ENSMUSP00000122815.2, ENSMUST00000149359.2

Conserved Domains (4) summary

smart00707
Location:128 → 153

RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

pfam02037
Location:383 → 416

SAP; SAP domain

pfam02755
Location:86 → 107

RPEL; RPEL repeat

pfam09903
Location:551 → 588

DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
NM_181860.1 → NP_862908.1 myocardin-related transcription factor B isoform 2

See identical proteins and their annotated locations for NP_862908.1

Status: VALIDATED

Source sequence(s)

BC028459

Consensus CDS

CCDS37257.1

UniProtKB/TrEMBL

Q8R2L3

Related

ENSMUSP00000054993.7, ENSMUST00000056715.7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

13073913..13235393

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522109.5 → XP_006522172.1 myocardin-related transcription factor B isoform X1

See identical proteins and their annotated locations for XP_006522172.1

UniProtKB/TrEMBL

A0A8D4USI8, A3KMF2

Conserved Domains (5) summary

PHA03247
Location:218 → 342

PHA03247; large tegument protein UL36; Provisional

pfam02037
Location:415 → 448

SAP; SAP domain

pfam02755
Location:162 → 184

RPEL; RPEL repeat

cl20817
Location:586 → 626

GBP_C; Guanylate-binding protein, C-terminal domain

cl29414
Location:73 → 97

RPEL; RPEL repeat
XM_030249105.2 → XP_030104965.1 myocardin-related transcription factor B isoform X2

UniProtKB/TrEMBL

A3KMF2, G3X8R8

Conserved Domains (5) summary

PHA03247
Location:197 → 321

PHA03247; large tegument protein UL36; Provisional

pfam02037
Location:394 → 427

SAP; SAP domain

pfam02755
Location:141 → 163

RPEL; RPEL repeat

cl20817
Location:565 → 605

GBP_C; Guanylate-binding protein, C-terminal domain

cl29414
Location:52 → 76

RPEL; RPEL repeat
XM_006522108.4 → XP_006522171.1 myocardin-related transcription factor B isoform X1

See identical proteins and their annotated locations for XP_006522171.1

UniProtKB/TrEMBL

A0A8D4USI8, A3KMF2

Conserved Domains (5) summary

PHA03247
Location:218 → 342

PHA03247; large tegument protein UL36; Provisional

pfam02037
Location:415 → 448

SAP; SAP domain

pfam02755
Location:162 → 184

RPEL; RPEL repeat

cl20817
Location:586 → 626

GBP_C; Guanylate-binding protein, C-terminal domain

cl29414
Location:73 → 97

RPEL; RPEL repeat
XM_006522111.3 → XP_006522174.1 myocardin-related transcription factor B isoform X3

See identical proteins and their annotated locations for XP_006522174.1

UniProtKB/TrEMBL

Q8R2L3

Related

ENSMUSP00000111476.2, ENSMUST00000115809.8
XM_030249106.2 → XP_030104966.1 myocardin-related transcription factor B isoform X2

UniProtKB/TrEMBL

A3KMF2, G3X8R8

Conserved Domains (5) summary

PHA03247
Location:197 → 321

PHA03247; large tegument protein UL36; Provisional

pfam02037
Location:394 → 427

SAP; SAP domain

pfam02755
Location:141 → 163

RPEL; RPEL repeat

cl20817
Location:565 → 605

GBP_C; Guanylate-binding protein, C-terminal domain

cl29414
Location:52 → 76

RPEL; RPEL repeat
XM_036159917.1 → XP_036015810.1 myocardin-related transcription factor B isoform X1

UniProtKB/TrEMBL

A0A8D4USI8, A3KMF2

Conserved Domains (5) summary

PHA03247
Location:218 → 342

PHA03247; large tegument protein UL36; Provisional

pfam02037
Location:415 → 448

SAP; SAP domain

pfam02755
Location:162 → 184

RPEL; RPEL repeat

cl20817
Location:586 → 626

GBP_C; Guanylate-binding protein, C-terminal domain

cl29414
Location:73 → 97

RPEL; RPEL repeat
XM_030249104.2 → XP_030104964.1 myocardin-related transcription factor B isoform X1

UniProtKB/TrEMBL

A0A8D4USI8, A3KMF2

Conserved Domains (5) summary

PHA03247
Location:218 → 342

PHA03247; large tegument protein UL36; Provisional

pfam02037
Location:415 → 448

SAP; SAP domain

pfam02755
Location:162 → 184

RPEL; RPEL repeat

cl20817
Location:586 → 626

GBP_C; Guanylate-binding protein, C-terminal domain

cl29414
Location:73 → 97

RPEL; RPEL repeat