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    Ints13 integrator complex subunit 13 [ Mus musculus (house mouse) ]

    Gene ID: 71177, updated on 12-May-2024

    Summary

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    Official Symbol
    Ints13provided by MGI
    Official Full Name
    integrator complex subunit 13provided by MGI
    Primary source
    MGI:MGI:1918427
    See related
    Ensembl:ENSMUSG00000040250 AllianceGenome:MGI:1918427
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Asun; Spata30; 4933424B01Rik
    Summary
    Predicted to be involved in centrosome localization and regulation of mitotic cell cycle. Predicted to act upstream of or within mitotic spindle organization and protein localization to nuclear envelope. Located in cytoplasm and nucleus. Orthologous to human INTS13 (integrator complex subunit 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 16.0), testis adult (RPKM 14.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 G3; 6 77.7 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (146446253..146479333, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (146549632..146577835, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-triphosphate receptor 2 Neighboring gene STARR-seq mESC enhancer starr_17800 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:146430030-146430213 Neighboring gene predicted gene, 53317 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:146438434-146438668 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:146470563-146470746 Neighboring gene STARR-positive B cell enhancer ABC_E10421 Neighboring gene predicted gene, 53316 Neighboring gene FGFR1 oncogene partner 2 Neighboring gene transmembrane 7 superfamily member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry. Jodoin JN, et al. Mol Biol Cell, 2012 Dec. PMID 23097494, Free PMC Article
    2. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. Jodoin JN, et al. Mol Biol Cell, 2013 Sep. PMID 23904267, Free PMC Article
    3. Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Latos PA, et al. Genes Dev, 2015 Dec 1. PMID 26584622, Free PMC Article
    4. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Grebien F, et al. Nat Chem Biol, 2015 Aug. PMID 26167872, Free PMC Article
    5. A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. Gagliardi A, et al. EMBO J, 2013 Aug 14. PMID 23892456, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28965

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centrosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within centrosome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    integrator complex subunit 13
    Names
    asunder, spermatogenesis regulator
    cell cycle regulator Mat89Bb homolog
    likely orthologue of H. sapiens chromosome 12 open reading frame 11 (C12orf11)
    protein asunder homolog
    spermatogenesis associated 30
    spermatogenesis-associated protein 30

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362106.1 → NP_001349035.1  integrator complex subunit 13 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC124128
      Conserved Domains (1) summary
      pfam10221
      Location:7 → 698
      DUF2151; Cell cycle and development regulator

    2. NM_001362107.1 → NP_001349036.1  integrator complex subunit 13 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC124128
      Conserved Domains (1) summary
      pfam10221
      Location:7 → 694
      DUF2151; Cell cycle and development regulator

    3. NM_001362108.1 → NP_001349037.1  integrator complex subunit 13 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon and compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC124128
      Conserved Domains (1) summary
      pfam10221
      Location:4 → 692
      DUF2151; Cell cycle and development regulator

    4. NM_138757.2 → NP_620096.2  integrator complex subunit 13 isoform 2

      See identical proteins and their annotated locations for NP_620096.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC124128, BE685943, BI986549, BY741532, CD560819, CF167981, CF949591, CK618181
      Consensus CDS
      CCDS39710.1
      UniProtKB/Swiss-Prot
      E9QLV7, Q8QZV7, Q99JT8
      Related
      ENSMUSP00000032427.9, ENSMUST00000032427.15
      Conserved Domains (1) summary
      pfam10221
      Location:4 → 692
      DUF2151; Cell cycle and development regulator

    RNA

    1. NR_155292.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon and uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC124128

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      146446253..146479333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152306.1 → XP_036008199.1  integrator complex subunit 13 isoform X2

      Conserved Domains (1) summary
      pfam10221
      Location:4 → 692
      DUF2151; Cell cycle and development regulator

    2. XM_030255594.2 → XP_030111454.1  integrator complex subunit 13 isoform X1

      UniProtKB/Swiss-Prot
      E9QLV7, Q8QZV7, Q99JT8
      Conserved Domains (1) summary
      pfam10221
      Location:4 → 692
      DUF2151; Cell cycle and development regulator

    RNA

    1. XR_003956254.2 RNA Sequence

    2. XR_004933623.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8QZV7.2 GenPept UniProtKB/Swiss-Prot:Q8QZV7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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