STARD10 StAR related lipid transfer domain containing 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STARD10provided by HGNC
Official Full Name: StAR related lipid transfer domain containing 10provided by HGNC
Primary source: HGNC:HGNC:10666
See related: Ensembl:ENSG00000214530 MIM:617382; AllianceGenome:HGNC:10666
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PCTP2; CGI-52; NY-CO-28; SDCCAG28
Summary: Predicted to enable lipid binding activity. Predicted to be involved in lipid transport. Predicted to act upstream of or within bile acid secretion and positive regulation of peroxisome proliferator activated receptor signaling pathway. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver (RPKM 47.9), stomach (RPKM 44.9) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q13.4

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (72754729..72794047, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (72682966..72722274, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (72465774..72505092, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Finding proved that STARD10 and ERBB2 positively regulate each other's expression and function.
Title: Star-related lipid transfer protein 10 (STARD10): a novel key player in alcohol-induced breast cancer progression.
Hence, we provide a molecular explanation for acquired resistance to DTX that is caused by the miR-638 deficiency and subsequent STARD10 upregulation. In consequence, alteration of miR-638/STARD10 cascade may represent an attractive strategy in future adjuvant therapy along with DTX chemotherapy.
Title: Potentiation of docetaxel sensitivity by miR-638 via regulation of STARD10 pathway in human breast cancer cells.
StarD10 is required for normal insulin secretion, though its deletion enhances proinsulin processing.
Title: Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Data show that in multivariate analyses incorporating tumor size, tumor grade, lymph node status, ER, PR and HER2 status, low STARD10 expression was an independent predictor of death from breast cancer.
Title: Loss of STARD10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative status.
C-terminal StarD10 phosphorylation on serine 284 regulates its association with cellular membranes
Title: Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity.
StarD10 interacts with phosphatidylcholine and phosphatidylethanolamine and preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position
Title: StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein.
Stard10 (Sdccag28) is much more highly transcribed in mouse cardiac atria than in cardiac ventricles.
Title: Transcriptional profiling of the heart reveals chamber-specific gene expression patterns.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_16447-16448:1019678436:1 (e-PCR)
- UniSTS:268040

MARC_16447-16448:1033413219:3 (e-PCR)
- UniSTS:268040

RH12670 (e-PCR)
- UniSTS:75807

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in intercellular canaliculus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: START domain-containing protein 10

Names: PCTP-L; PCTP-like protein; START domain containing 10; StAR-related lipid transfer (START) domain containing 10; antigen NY-CO-28; serologically defined colon cancer antigen 28; stAR-related lipid transfer protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006645.3 → NP_006636.2 START domain-containing protein 10

See identical proteins and their annotated locations for NP_006636.2

Status: VALIDATED

Source sequence(s)

AP002381, AP003065

Consensus CDS

CCDS41688.1

UniProtKB/Swiss-Prot

O60532, Q9Y365

UniProtKB/TrEMBL

B3KTJ1

Related

ENSP00000335247.6, ENST00000334805.11

Conserved Domains (1) summary

cd08871
Location:19 → 241

START_STARD10-like; Lipid-binding START domain of mammalian STARD10 and related proteins