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    Pcm1 pericentriolar material 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81740, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Pcm1provided by RGD
    Official Full Name
    pericentriolar material 1provided by RGD
    Primary source
    RGD:620901
    See related
    Ensembl:ENSRNOG00000010155 AllianceGenome:RGD:620901
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Involved in protein localization to centrosome. Predicted to be located in several cellular components, including ciliary transition zone; nuclear membrane; and pericentriolar material. Predicted to be part of protein-containing complex. Predicted to be active in centriolar satellite; centriole; and ciliary basal body. Predicted to colocalize with centrosome. Orthologous to human PCM1 (pericentriolar material 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 287.9), Testes (RPKM 285.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    16q12.1
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (57711833..57808842, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (51008315..51105261, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (54040721..54137675, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547443 Neighboring gene FSHD region gene 1 Neighboring gene N-acylsphingosine amidohydrolase 1 Neighboring gene fibrinogen-like 1 Neighboring gene microtubule associated scaffold protein 1 Neighboring gene uncharacterized LOC103693968

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Neuroanatomical and behavioral deficits in mice haploinsufficient for Pericentriolar material 1 (Pcm1). Zoubovsky S, et al. Neurosci Res, 2015 Sep. PMID 25697395, Free PMC Article
    2. Arrest of cell cycle progression during first interphase in murine zygotes microinjected with anti-PCM-1 antibodies. Balczon R, et al. Cell Motil Cytoskeleton, 2002 Jul. PMID 12112146
    3. Non-membranous granular organelle consisting of PCM-1: subcellular distribution and cell-cycle-dependent assembly/disassembly. Kubo A, et al. J Cell Sci, 2003 Mar 1. PMID 12571289
    4. Centriolar satellites: molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis. Kubo A, et al. J Cell Biol, 1999 Nov 29. PMID 10579718, Free PMC Article
    5. A CaMKIIβ signaling pathway at the centrosome regulates dendrite patterning in the brain. Puram SV, et al. Nat Neurosci, 2011 Jul 3. PMID 21725312, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in centrosome cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within interkinetic nuclear migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intraciliary transport involved in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary transport involved in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule anchoring ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule anchoring at centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule anchoring at centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuronal stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to centrosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex localization to centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein complex stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within social behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centriolar satellite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary transition zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in non-motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in pericentriolar material ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pericentriolar material 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031076.1 → NP_112338.1  pericentriolar material 1 protein

      See identical proteins and their annotated locations for NP_112338.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I5ZUW5, A6JPT8, G3V7E6
      Related
      ENSRNOP00000014202.4, ENSRNOT00000014202.7
      Conserved Domains (1) summary
      pfam15717
      Location:1369 → 2000
      PCM1_C; Pericentriolar material 1 C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      57711833..57808842 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008771284.4 → XP_008769506.1  pericentriolar material 1 protein isoform X1

      See identical proteins and their annotated locations for XP_008769506.1

      UniProtKB/TrEMBL
      A0A8I5ZUW5
      Conserved Domains (2) summary
      pfam15717
      Location:1471 → 2102
      PCM1_C; Pericentriolar material 1 C terminus
      cl00439
      Location:845 → 929
      UPF0047; uncharacterized protein family UPF0047

    2. XM_006253188.5 → XP_006253250.1  pericentriolar material 1 protein isoform X6

      See identical proteins and their annotated locations for XP_006253250.1

      UniProtKB/TrEMBL
      A0A8I5ZUW5, A0A8I6A6S1, A6JPT9
      Related
      ENSRNOP00000089217.1
      Conserved Domains (2) summary
      pfam15717
      Location:1408 → 2039
      PCM1_C; Pericentriolar material 1 C terminus
      cl00439
      Location:782 → 866
      UPF0047; uncharacterized protein family UPF0047

    3. XM_006253183.5 → XP_006253245.1  pericentriolar material 1 protein isoform X1

      See identical proteins and their annotated locations for XP_006253245.1

      UniProtKB/TrEMBL
      A0A8I5ZUW5
      Conserved Domains (2) summary
      pfam15717
      Location:1471 → 2102
      PCM1_C; Pericentriolar material 1 C terminus
      cl00439
      Location:845 → 929
      UPF0047; uncharacterized protein family UPF0047

    4. XM_063275772.1 → XP_063131842.1  pericentriolar material 1 protein isoform X13

      UniProtKB/TrEMBL
      A0A8I5Y9X1

    5. XM_063275770.1 → XP_063131840.1  pericentriolar material 1 protein isoform X11

    6. XM_017600257.3 → XP_017455746.1  pericentriolar material 1 protein isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZUW5
      Related
      ENSRNOP00000078093.1

    7. XM_039094854.2 → XP_038950782.1  pericentriolar material 1 protein isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZUW5
      Conserved Domains (1) summary
      pfam15717
      Location:1432 → 2063
      PCM1_C; Pericentriolar material 1 C-terminus

    8. XM_063275771.1 → XP_063131841.1  pericentriolar material 1 protein isoform X12

    9. XM_063275769.1 → XP_063131839.1  pericentriolar material 1 protein isoform X9

    10. XM_039094856.2 → XP_038950784.1  pericentriolar material 1 protein isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZUW5
      Conserved Domains (1) summary
      pfam15717
      Location:1353 → 1984
      PCM1_C; Pericentriolar material 1 C-terminus

    11. XM_006253187.5 → XP_006253249.1  pericentriolar material 1 protein isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZUW5
      Conserved Domains (2) summary
      pfam15717
      Location:1413 → 2044
      PCM1_C; Pericentriolar material 1 C terminus
      cl00439
      Location:787 → 871
      UPF0047; uncharacterized protein family UPF0047

    12. XM_006253186.5 → XP_006253248.1  pericentriolar material 1 protein isoform X4

      UniProtKB/TrEMBL
      A0A0G2K0X1, A0A8I5ZUW5
      Related
      ENSRNOP00000071613.2
      Conserved Domains (3) summary
      pfam02463
      Location:226 → 987
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam15717
      Location:1416 → 2047
      PCM1_C; Pericentriolar material 1 C terminus
      cl00439
      Location:845 → 929
      UPF0047; uncharacterized protein family UPF0047

    13. XM_006253185.5 → XP_006253247.1  pericentriolar material 1 protein isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZUW5
      Conserved Domains (2) summary
      pfam15717
      Location:1471 → 2049
      PCM1_C; Pericentriolar material 1 C terminus
      cl00439
      Location:845 → 929
      UPF0047; uncharacterized protein family UPF0047

    14. XM_006253184.5 → XP_006253246.1  pericentriolar material 1 protein isoform X1

      See identical proteins and their annotated locations for XP_006253246.1

      UniProtKB/TrEMBL
      A0A8I5ZUW5
      Related
      ENSRNOP00000082952.1
      Conserved Domains (2) summary
      pfam15717
      Location:1471 → 2102
      PCM1_C; Pericentriolar material 1 C terminus
      cl00439
      Location:845 → 929
      UPF0047; uncharacterized protein family UPF0047

    15. XM_063275766.1 → XP_063131836.1  pericentriolar material 1 protein isoform X7

      UniProtKB/TrEMBL
      A6JPT8, G3V7E6

    16. XM_063275765.1 → XP_063131835.1  pericentriolar material 1 protein isoform X6

      UniProtKB/TrEMBL
      A0A8I6A6S1, A6JPT9

    17. XM_063275768.1 → XP_063131838.1  pericentriolar material 1 protein isoform X7

      UniProtKB/TrEMBL
      A6JPT8, G3V7E6

    18. XM_063275762.1 → XP_063131832.1  pericentriolar material 1 protein isoform X1

    19. XM_008771285.4 → XP_008769507.1  pericentriolar material 1 protein isoform X1

      See identical proteins and their annotated locations for XP_008769507.1

      UniProtKB/TrEMBL
      A0A8I5ZUW5
      Conserved Domains (2) summary
      pfam15717
      Location:1471 → 2102
      PCM1_C; Pericentriolar material 1 C terminus
      cl00439
      Location:845 → 929
      UPF0047; uncharacterized protein family UPF0047

    20. XM_063275767.1 → XP_063131837.1  pericentriolar material 1 protein isoform X7

      UniProtKB/TrEMBL
      A6JPT8, G3V7E6

    21. XM_063275764.1 → XP_063131834.1  pericentriolar material 1 protein isoform X1

    22. XM_063275763.1 → XP_063131833.1  pericentriolar material 1 protein isoform X1

    23. XM_063275773.1 → XP_063131843.1  pericentriolar material 1 protein isoform X14

    Nucleotide Protein Strain
    Heading Accession and Version

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