U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pgpep1 pyroglutamyl-peptidase I [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290648, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Pgpep1provided by RGD
    Official Full Name
    pyroglutamyl-peptidase Iprovided by RGD
    Primary source
    RGD:1303133
    See related
    Ensembl:ENSRNOG00000019639 AllianceGenome:RGD:1303133
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PAPI
    Summary
    Predicted to enable pyroglutamyl-peptidase activity. Involved in proteolysis. Located in cytosol. Orthologous to human PGPEP1 (pyroglutamyl-peptidase I). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 1611.9), Liver (RPKM 468.3) and 5 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    16p14
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18804408..18817466)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18770563..18782968)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20521989..20531254)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene JunD proto-oncogene, AP-1 transcription factor subunit Neighboring gene uncharacterized LOC134482471 Neighboring gene LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene Mk1 protein Neighboring gene growth differentiation factor 15 Neighboring gene leucine rich repeat containing 25 Neighboring gene single stranded DNA binding protein 4

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Hydrolysis of synthetic substrate, L-pyroglutamyl p-nitroanilide is catalyzed solely by pyroglutamyl aminopeptidase I in rat liver cytosol. Abe K, et al. Biol Pharm Bull, 2003 Nov. PMID 14600395
    2. Serum pyrrolidone carboxypeptidase activity in N-methyl-nitrosourea induced rat breast cancer. Carrera MP, et al. Horm Metab Res, 2003 Aug. PMID 12953169
    3. Effect of the disruption of body fluid balance on pyroglutamyl aminopeptidase (Type-1) in rat brain structures. Irazusta J, et al. Neuropeptides, 2002 Oct. PMID 12450739
    4. Continuous stress-induced dopamine dysregulation augments PAP-I and PAP-II expression in melanotrophs of the pituitary gland. Konishi H, et al. Biochem Biophys Res Commun, 2011 Apr 1. PMID 21329657
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PAP-I and PAP-II expression was induced by the decreased dopamine levels in the intermediate lobe of the pituitary under continuous stress.
      Title: Continuous stress-induced dopamine dysregulation augments PAP-I and PAP-II expression in melanotrophs of the pituitary gland.
    2. Significant correlation between Pcp activity and the number and size of tumours and the body weight of the animals. Decreased Pcp may reflect increase in circulating GnRH leading to increase in gonadal steroid hormones.
      Title: Serum pyrrolidone carboxypeptidase activity in N-methyl-nitrosourea induced rat breast cancer.
    3. Pyroglutamyl aminopeptidase Type-1 shows differentiated activity in various parts of the brain under varied conditions of hydration in rats.
      Title: Effect of the disruption of body fluid balance on pyroglutamyl aminopeptidase (Type-1) in rat brain structures.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyroglutamyl-peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    pyroglutamyl-peptidase 1
    Names
    5-oxoprolyl-peptidase
    PAP-I
    PGP-I
    pyroglutamyl aminopeptidase I
    pyrrolidone-carboxylate peptidase
    NP_973717.1
    XP_038950248.1
    XP_063131229.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201988.2 → NP_973717.1  pyroglutamyl-peptidase 1

      See identical proteins and their annotated locations for NP_973717.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098645
      UniProtKB/Swiss-Prot
      Q76IC5
      UniProtKB/TrEMBL
      A0A8I6B2L0, A6KA15
      Related
      ENSRNOP00000026597.5, ENSRNOT00000026597.7
      Conserved Domains (1) summary
      cd00501
      Location:6 → 199
      Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      18804408..18817466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094320.2 → XP_038950248.1  pyroglutamyl-peptidase 1 isoform X1

      Conserved Domains (1) summary
      cl00237
      Location:1 → 122
      Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

    2. XM_063275159.1 → XP_063131229.1  pyroglutamyl-peptidase 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q76IC5.1 GenPept UniProtKB/Swiss-Prot:Q76IC5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous