H2-Eb1 histocompatibility 2, class II antigen E beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H2-Eb1provided by MGI
Official Full Name: histocompatibility 2, class II antigen E betaprovided by MGI
Primary source: MGI:MGI:95901
See related: Ensembl:ENSMUSG00000060586 AllianceGenome:MGI:95901
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Eb; Ia4; H2Eb; Ia-4; H-2Eb
Summary: Predicted to enable several functions, including MHC class II receptor activity; peptide antigen binding activity; and signaling receptor binding activity. Involved in response to interferon-gamma. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II. Predicted to be located in external side of plasma membrane and immunological synapse. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Is expressed in lung. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); eye disease (multiple); and sarcoidosis (multiple). Orthologous to human HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) and HLA-DRB5 (major histocompatibility complex, class II, DR beta 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 375.3), large intestine adult (RPKM 229.1) and 12 other tissues See more
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34524841..34535648)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (34305867..34316674)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

may play an important role in regulating Th1/Th2 balance during the pathogenesis of allergic rhinitis
Title: H2-EB1 Molecule Alleviates Allergic Rhinitis Symptoms of H2-Eb1 Knockout Mice.
Evidence that MHC I-E dampens thyroid autoantibodies and prevents spreading to a second thyroid autoantigen in I-A(k) NOD mice.
Title: Evidence that MHC I-E dampens thyroid autoantibodies and prevents spreading to a second thyroid autoantigen in I-A(k) NOD mice.
H2-Eb1 expression was significantly upregulated in the nasal mucosa of our successfully established allergic rhinitis mouse model
Title: H2-Eb1 expression is upregulated in the nasal mucosa of allergic rhinitis.
Data demonstrate that the presence of distinct forms of MHC-II with plasma membrane lipid rafts is required for MHC-II aggregation in APCs.
Title: Distinct MHC class II molecules are associated on the dendritic cell surface in cholesterol-dependent membrane microdomains.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (7)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H2-Eb1 (e-PCR), detects polymorphism
- UniSTS:238120

H2-Eb1 (e-PCR), detects polymorphism
- UniSTS:143304

H2-Eb1 (e-PCR), detects polymorphism
- UniSTS:143305

H2-Eb1 (e-PCR), detects polymorphism
- UniSTS:143306

H2-Eb1 (e-PCR), detects polymorphism
- UniSTS:143307

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CD4 receptor binding	ISO Inferred from Sequence Orthology more info
enables MHC class II protein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables MHC class II receptor activity	ISO Inferred from Sequence Orthology more info
enables T cell receptor binding	ISO Inferred from Sequence Orthology more info
enables peptide antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide antigen binding	ISO Inferred from Sequence Orthology more info
enables polysaccharide binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in antigen processing and presentation	IEA Inferred from Electronic Annotation more info
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	IEA Inferred from Electronic Annotation more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in peptide antigen assembly with MHC class II protein complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to type II interferon	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of MHC class II protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MHC class II protein complex	ISO Inferred from Sequence Orthology more info
part_of MHC class II protein complex	TAS Traceable Author Statement more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: H-2 class II histocompatibility antigen, I-E beta chain

Names: I-E beta MHC class II; MHC H2-IE-beta cell surface glycoprotein; MHC class II IE-b; cell surface glycoprotein; histocompatibility 2, class II antigen E beta, promoter 1; major histocompatibility complex H-2E beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010382.2 → NP_034512.2 H-2 class II histocompatibility antigen, I-E beta chain precursor

See identical proteins and their annotated locations for NP_034512.2

Status: VALIDATED

Source sequence(s)

AK160485, BY202562, CAAA01111730

Consensus CDS

CCDS37584.1

UniProtKB/Swiss-Prot

O78226, P04230

UniProtKB/TrEMBL

F6VX29, O78196

Related

ENSMUSP00000158533.2, ENSMUST00000235530.2

Conserved Domains (2) summary

pfam00969
Location:40 → 114

MHC_II_beta; Class II histocompatibility antigen, beta domain

cl11960
Location:124 → 217

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

34524841..34535648

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P04230.1	GenPept	UniProtKB/Swiss-Prot:P04230
P04231.1	GenPept	UniProtKB/Swiss-Prot:P04231
P18468.1	GenPept	UniProtKB/Swiss-Prot:P18468
P18469.1	GenPept	UniProtKB/Swiss-Prot:P18469
P20040.1	GenPept	UniProtKB/Swiss-Prot:P20040