Slc47a1 solute carrier family 47 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc47a1provided by RGD
Official Full Name: solute carrier family 47 member 1provided by RGD
Primary source: RGD:1311123
See related: Ensembl:ENSRNOG00000057404 AllianceGenome:RGD:1311123
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MATE1; RGD1311123
Summary: Enables amide transmembrane transporter activity and xenobiotic transmembrane transporter activity. Involved in cation transmembrane transport and organic cation transport. Located in vesicle. Orthologous to human SLC47A1 (solute carrier family 47 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1304.3) See more
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Genomic context

Location:: 10q22

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (46533580..46590128, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (46034115..46088617, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (47631425..47685379, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Although multiple factors may influence renal handling of drugs, these observations can be accounted for, at least in part, by downregulation of Mate1-mediated apical efflux from tubular cells and Oct2-mediated basolateral uptake. Our results suggest that hyperuricemia could alter the disposition of drugs that are substrates of Mate1 and/or Oct2.
Title: Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia.
mechanism involved in further increasing biliary ADMA levels in sham and I/R groups treated with OCA appears to be MATE-1-dependent
Title: The farnesoid X receptor agonist obeticholic acid upregulates biliary excretion of asymmetric dimethylarginine via MATE-1 during hepatic ischemia/reperfusion injury.
Inhibitory effect of atenolol on urinary excretion of metformin via down-regulating MATE1 expression in the kidney of rats
Title: Inhibitory effect of atenolol on urinary excretion of metformin via down-regulating multidrug and toxin extrusion protein 1 (rMate1) expression in the kidney of rats.
renal mRNA level of multidrug and toxin extrusions-1 did not show an age-related increase; the increase in creatinine clearance highly contributed to the age-related increase in urinary creatinine excretion compared to mRNA levels of Oct2 and Mate1
Title: Underestimation of urinary biomarker-to-creatinine ratio resulting from age-related gain in muscle mass in rats.
Sp1 functions as basal transcriptional regulator of human and rat MATE1 gene through two GC boxes. May be conserved among species. We have identified rSNP of hMATE1 gene (G-32A) (belonging to Sp1-binding site) that affects promoter activity.
Title: Critical roles of Sp1 in gene expression of human and rat H+/organic cation antiporter MATE1.
MATE1 is expressed in the renal proximal tubules and can mediate the transport of various organic cations and cephalexin using an oppositely directed H+ gradient
Title: Molecular cloning, functional characterization and tissue distribution of rat H+/organic cation antiporter MATE1.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-arginine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-arginine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amide transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables antiporter activity	ISO Inferred from Sequence Orthology more info
enables organic cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic cation transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables polyspecific organic cation:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables polyspecific organic cation:proton antiporter activity	IEA Inferred from Electronic Annotation more info
enables polyspecific organic cation:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables putrescine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables putrescine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables putrescine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables thiamine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables thiamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables thiamine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables xenobiotic transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables xenobiotic transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables xenobiotic transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-alpha-amino acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-arginine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-arginine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-arginine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in amide transport	IEA Inferred from Electronic Annotation more info
involved_in amino acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organic cation transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in organic cation transport	IDA Inferred from Direct Assay more info	PubMed
involved_in organic cation transport	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in putrescine transport	IEA Inferred from Electronic Annotation more info
involved_in putrescine transport	ISO Inferred from Sequence Orthology more info
involved_in putrescine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in thiamine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: multidrug and toxin extrusion protein 1

Names: MATE-1; rMATE-1; solute carrier family 47 (multidrug and toxin extrusion), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014118.2 → NP_001014140.1 multidrug and toxin extrusion protein 1

See identical proteins and their annotated locations for NP_001014140.1

Status: PROVISIONAL

Source sequence(s)

AB248823

UniProtKB/Swiss-Prot

Q0KKE7, Q5I0E9

UniProtKB/TrEMBL

A0A8L2R9P7

Related

ENSRNOP00000074897.2, ENSRNOT00000086579.2

Conserved Domains (1) summary

cd13132
Location:33 → 467

MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

46533580..46590128 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269334.1 → XP_063125404.1 multidrug and toxin extrusion protein 1 isoform X2
XM_063269333.1 → XP_063125403.1 multidrug and toxin extrusion protein 1 isoform X1