Glyat glycine-N-acyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Glyatprovided by RGD
Official Full Name: glycine-N-acyltransferaseprovided by RGD
Primary source: RGD:1307163
See related: Ensembl:ENSRNOG00000012142 AllianceGenome:RGD:1307163
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable glycine N-acyltransferase activity and glycine N-benzoyltransferase activity. Predicted to be involved in benzoyl-CoA metabolic process; glycine metabolic process; and monocarboxylic acid metabolic process. Predicted to be active in mitochondrion. Orthologous to human GLYAT (glycine-N-acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 2161.8) See more
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Genomic context

Location:: 1q43

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (219128798..219149615)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (209704213..209724949)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (229060125..229081113)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that the up-regulation of phase II detoxification in the DR group was confirmed by mRNA and protein expression levels of uridinediphospho-glucuronosyltransferase and glycine-N-acyltransferase in actual liver tissues.
Title: Enhanced phase II detoxification contributes to beneficial effects of dietary restriction as revealed by multi-platform metabolomics studies.

Submit: New GeneRIF Correction

General gene information

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Markers

AI233103 (e-PCR)
- UniSTS:260933

D1Got209 (e-PCR)
- UniSTS:113098

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glycine N-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine N-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycine N-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glycine N-benzoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine N-benzoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycine N-benzoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glycine N-benzoyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in benzoyl-CoA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in benzoyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in monocarboxylic acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: glycine N-acyltransferase

Names: AAc; acyl-CoA:glycine N-acyltransferase; aralkyl acyl-CoA N-acyltransferase; aralkyl acyl-CoA:amino acid N-acyltransferase; benzoyl-coenzyme A:glycine N-acyltransferase; glycine N-benzoyltransferase; liver regeneration-related protein LRRG067

NP_001009648.1

EC 2.3.1.13

EC 2.3.1.71

NP_001399482.1

EC 2.3.1.13

EC 2.3.1.71

XP_038964631.1

EC 2.3.1.13

EC 2.3.1.71

XP_038964632.1

EC 2.3.1.13

EC 2.3.1.71

XP_063143048.1

EC 2.3.1.13

EC 2.3.1.71

XP_063143049.1

EC 2.3.1.13

EC 2.3.1.71

XP_063143050.1

EC 2.3.1.13

EC 2.3.1.71

XP_063143052.1

EC 2.3.1.13

EC 2.3.1.71

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009648.3 → NP_001009648.1 glycine N-acyltransferase

See identical proteins and their annotated locations for NP_001009648.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q5PQT3, Q7TP56

UniProtKB/TrEMBL

A0A0G2JWI5, A4PB92

Conserved Domains (2) summary

pfam08444
Location:207 → 295

Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region

pfam06021
Location:1 → 206

Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase
NM_001412553.1 → NP_001399482.1 glycine N-acyltransferase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q5PQT3, Q7TP56

UniProtKB/TrEMBL

A4PB92

Related

ENSRNOP00000016454.3, ENSRNOT00000016454.6

RNA

NR_178215.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

219128798..219149615

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286978.1 → XP_063143048.1 glycine N-acyltransferase isoform X1

UniProtKB/Swiss-Prot

Q5PQT3, Q7TP56

UniProtKB/TrEMBL

A4PB92
XM_063286980.1 → XP_063143050.1 glycine N-acyltransferase isoform X1

UniProtKB/Swiss-Prot

Q5PQT3, Q7TP56

UniProtKB/TrEMBL

A4PB92
XM_063286979.1 → XP_063143049.1 glycine N-acyltransferase isoform X1

UniProtKB/Swiss-Prot

Q5PQT3, Q7TP56

UniProtKB/TrEMBL

A4PB92
XM_063286982.1 → XP_063143052.1 glycine N-acyltransferase isoform X1

UniProtKB/Swiss-Prot

Q5PQT3, Q7TP56

UniProtKB/TrEMBL

A4PB92
XM_039108703.2 → XP_038964631.1 glycine N-acyltransferase isoform X2

Conserved Domains (2) summary

pfam08444
Location:143 → 231

Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region

pfam06021
Location:1 → 142

Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase
XM_039108704.2 → XP_038964632.1 glycine N-acyltransferase isoform X2

Conserved Domains (2) summary

pfam08444
Location:143 → 231

Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region

pfam06021
Location:1 → 142

Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase