FCER2 Fc epsilon receptor II [Homo sapiens (human)] - Gene

Summary

Official Symbol: FCER2provided by HGNC
Official Full Name: Fc epsilon receptor IIprovided by HGNC
Primary source: HGNC:HGNC:3612
See related: Ensembl:ENSG00000104921 MIM:151445; AllianceGenome:HGNC:3612
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD23; FCE2; CD23A; IGEBF; CLEC4J; FCErII; BLAST-2
Summary: The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Expression: Biased expression in spleen (RPKM 20.9), lymph node (RPKM 16.3) and 4 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (7688776..7702131, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (7689661..7703156, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (7753662..7767017, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of CD23 Activated ERK Signaling Pathway in the Pathogenesis of Eosinophilic Chronic Sinusitis with Nasal Polyps.
Title: Role of CD23 Activated ERK Signaling Pathway in the Pathogenesis of Eosinophilic Chronic Sinusitis with Nasal Polyps.
IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases.
Title: IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases.
An FCER2 polymorphism is associated with increased oral leukotriene receptor antagonists and allergic rhinitis prescribing.
Title: An FCER2 polymorphism is associated with increased oral leukotriene receptor antagonists and allergic rhinitis prescribing.
Reviving lost binding sites: Exploring calcium-binding site transitions between human and murine CD23.
Title: Reviving lost binding sites: Exploring calcium-binding site transitions between human and murine CD23.
Bidirectional Transport of IgE by CD23 in the Inner Ear of Patients with Meniere's Disease.
Title: Bidirectional Transport of IgE by CD23 in the Inner Ear of Patients with Meniere's Disease.
Plasmablasts derive from CD23- activated B cells after the extinction of IL-4/STAT6 signaling and IRF4 induction.
Title: Plasmablasts derive from CD23- activated B cells after the extinction of IL-4/STAT6 signaling and IRF4 induction.
Correlations between exhaled nitric oxide, rs28364072 polymorphism of FCER2 gene, asthma control, and inhaled corticosteroid responsiveness in children with asthma.
Title: Correlations between exhaled nitric oxide, rs28364072 polymorphism of FCER2 gene, asthma control, and inhaled corticosteroid responsiveness in children with asthma.
CD23 mediated the induction of pro-inflammatory cytokines Interleukin-1 beta and tumor necrosis factors-alpha in Aspergillus fumigatus keratitis.
Title: CD23 mediated the induction of pro-inflammatory cytokines Interleukin-1 beta and tumor necrosis factors-alpha in Aspergillus fumigatus keratitis.
Human DC-SIGN and CD23 do not interact with human IgG.
Title: Human DC-SIGN and CD23 do not interact with human IgG.
FCER2 T2206C variant associated with FENO levels in asthmatic children using inhaled corticosteroids: The PACMAN study.
Title: FCER2 T2206C variant associated with FENO levels in asthmatic children using inhaled corticosteroids: The PACMAN study.

Submit: New GeneRIF Correction See all GeneRIFs (103)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 downregulates the expression of Fc fragment of IgE, low affinity receptor II (FCER2; CD23) in human B cells	PubMed
	env	CD23 protein membrane expression is upregulated by HIV-1 gp120 and this upregulation induces the production of nitric oxide (NO) and IL-1beta	PubMed
Envelope surface glycoprotein gp160, precursor	env	Antibodies against cell surface molecules LFA-1, ICAM-1, HLA-DR, and CD28 inhibit the HIV-1 gp160-induced B cell differentiation response; gp160 also induces IL-6R and CD23 molecule expression on B cells	PubMed
Nef	nef	In macrophages, activation of CD40 or expression of HIV-1 Nef induces the release of sCD23 and sICAM, which mediate effects on T lymphocytes, rendering them permissive to HIV-1 infection	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-M14766 (e-PCR)
- UniSTS:44277

PMC102084P2 (e-PCR)
- UniSTS:270071

PMC102084P3 (e-PCR)
- UniSTS:270072

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables IgE binding	IDA Inferred from Direct Assay more info	PubMed
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	TAS Traceable Author Statement more info	PubMed
enables low-affinity IgE receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell antigen processing and presentation	IDA Inferred from Direct Assay more info	PubMed
involved_in Fc receptor-mediated immune complex endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in Fc-epsilon receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in biological process involved in interspecies interaction between organisms	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in macrophage activation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of humoral immune response mediated by circulating immunoglobulin	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of killing of cells of another organism	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of nitric-oxide synthase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of nitric-oxide synthase biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular exosome	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: low affinity immunoglobulin epsilon Fc receptor

Names: C-type lectin domain family 4, member J; CD23 antigen; Fc fragment of IgE receptor II; Fc fragment of IgE, low affinity II, receptor for (CD23); FcepsilonRII; fc-epsilon-RII; immunoglobulin E-binding factor; immunoglobulin epsilon-chain; lymphocyte IgE receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029554.1 RefSeqGene

Range

5016..18371

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001207019.3 → NP_001193948.2 low affinity immunoglobulin epsilon Fc receptor isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate 5' terminal exon and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b, also known as CD23b) is shorter and has a distinct N-terminus, compared to isoform a. This variant is supported by data in PubMed IDs 12379312 and 15843555.

Source sequence(s)

AC008763, BC014108

UniProtKB/TrEMBL

K3W4U1

Related

ENSP00000353178.4, ENST00000360067.8

Conserved Domains (2) summary

smart00034
Location:162 → 281

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

cl23720
Location:76 → 152

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001220500.2 → NP_001207429.1 low affinity immunoglobulin epsilon Fc receptor isoform a

See identical proteins and their annotated locations for NP_001207429.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate donor splice site in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (a, also known as CD23a).

Source sequence(s)

BC062591, DA957269

Consensus CDS

CCDS12184.1

UniProtKB/Swiss-Prot

P06734

Related

ENSP00000471974.1, ENST00000597921.6

Conserved Domains (2) summary

smart00034
Location:163 → 282

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

cl23720
Location:77 → 153

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_002002.5 → NP_001993.2 low affinity immunoglobulin epsilon Fc receptor isoform a

See identical proteins and their annotated locations for NP_001993.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a, also known as CD23a). Both variants 1 and 3 encode the same isoform.

Source sequence(s)

BC014108, DA957269

Consensus CDS

CCDS12184.1

UniProtKB/Swiss-Prot

P06734

Related

ENSP00000264072.6, ENST00000346664.9

Conserved Domains (2) summary

smart00034
Location:163 → 282

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

cl23720
Location:77 → 153

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

7688776..7702131 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005272462.5 → XP_005272519.1 low affinity immunoglobulin epsilon Fc receptor isoform X1

See identical proteins and their annotated locations for XP_005272519.1

UniProtKB/Swiss-Prot

P06734

Conserved Domains (2) summary

smart00034
Location:163 → 282

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

cl23720
Location:77 → 153

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)