Ltf lactotransferrin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ltfprovided by RGD
Official Full Name: lactotransferrinprovided by RGD
Primary source: RGD:1305445
See related: Ensembl:ENSRNOG00000031779 AllianceGenome:RGD:1305445
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including cysteine-type endopeptidase inhibitor activity; heparin binding activity; and lipopolysaccharide binding activity. Predicted to be involved in several processes, including defense response to other organism; negative regulation of hydrolase activity; and regulation of signal transduction. Predicted to be located in cell surface and specific granule. Predicted to be part of protein-containing complex. Predicted to be active in endosome; extracellular space; and plasma membrane. Human ortholog(s) of this gene implicated in candidiasis; lung non-small cell carcinoma; and renal cell carcinoma. Orthologous to human LTF (lactotransferrin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 4.1), Thymus (RPKM 3.9) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (119878344..119901189)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (110999948..111022795)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (119290416..119313261)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lactoferrin promotes the autophagy activity during osteoblast formation via BCL2-Beclin1 signaling.
Title: Lactoferrin promotes the autophagy activity during osteoblast formation via BCL2-Beclin1 signaling.
Lf supplemented in food during lactation attenuated acute and long-term cerebral LPS-induced alterations. This provides a new evidence for a promising use of Lf as a preventive neuroprotective approach in preterm encephalopathy.
Title: Lactoferrin during lactation reduces lipopolysaccharide-induced brain injury.
Lactoferrin ameliorates the prostaglandin E2 inhibition of Na(+)-glucose cotransport most likely via the Ca(2+)- and cAMP-signaling pathways.
Title: Lactoferrin ameliorates prostaglandin E2-mediated inhibition of Na+ -glucose cotransport in enterocytes.
lactoferrin promotes rat osteoblastic cell survival by inducing cell proliferation and inhibiting apoptosis
Title: Lactoferrin potently inhibits osteoblast apoptosis, via an LRP1-independent pathway.
differential expression and estrogen responsiveness of the lactoferrin gene in different regions of the female reproductive tract [Lactoferrin]
Title: Differential expression and estrogen response of lactoferrin gene in the female reproductive tract of mouse, rat, and hamster.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables membrane destabilizing activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antibacterial humoral response	ISO Inferred from Sequence Orthology more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in bone morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response in mucosa	ISO Inferred from Sequence Orthology more info
involved_in iron ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation by host of viral process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of single-species biofilm formation in or on host organism	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral process	ISO Inferred from Sequence Orthology more info
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info
located_in specific granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lactotransferrin

Names: lactoferrin

NP_001100334.1

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106864.1 → NP_001100334.1 lactotransferrin precursor

See identical proteins and their annotated locations for NP_001100334.1

Status: PROVISIONAL

Source sequence(s)

CH473954

UniProtKB/TrEMBL

A6I3I7, D3ZAB1

Related

ENSRNOP00000048806.2, ENSRNOT00000047752.3

Conserved Domains (4) summary

smart00094
Location:363 → 692

TR_FER; Transferrin

cd13617
Location:360 → 691

PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily

pfam00405
Location:25 → 351

Transferrin; Transferrin

cl21456
Location:24 → 350

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily