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    Kank3 KN motif and ankyrin repeat domains 3 [ Mus musculus (house mouse) ]

    Gene ID: 80880, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Kank3provided by MGI
    Official Full Name
    KN motif and ankyrin repeat domains 3provided by MGI
    Primary source
    MGI:MGI:1098615
    See related
    Ensembl:ENSMUSG00000042099 AllianceGenome:MGI:1098615
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NG28; Ankrd47; D17Ertd288e; 0610013D04Rik
    Summary
    Predicted to be involved in negative regulation of actin filament polymerization. Predicted to act upstream of or within negative regulation of stress fiber assembly. Predicted to be active in cytoplasm and cytoskeleton. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; jaw bone; and liver. Orthologous to human KANK3 (KN motif and ankyrin repeat domains 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 77.6), adrenal adult (RPKM 51.6) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 B1; 17 17.98 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34029497..34041894)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33810523..33822920)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RAB11B, member RAS oncogene family Neighboring gene RAB11B, member RAS oncogene family, opposite strand 1 Neighboring gene STARR-positive B cell enhancer ABC_E82 Neighboring gene angiopoietin-like 4 Neighboring gene predicted gene, 53997 Neighboring gene STARR-seq mESC enhancer starr_42411 Neighboring gene STARR-positive B cell enhancer ABC_E956 Neighboring gene STARR-positive B cell enhancer ABC_E2482 Neighboring gene ribosomal protein S28 Neighboring gene NADH:ubiquinone oxidoreductase subunit A7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Kank proteins: a new family of ankyrin-repeat domain-containing proteins. Zhu Y, et al. Biochim Biophys Acta, 2008 Feb. PMID 17996375
    2. Identification of novel radiation-induced p53-dependent transcripts extensively regulated during mouse brain development. Quintens R, et al. Biol Open, 2015 Feb 13. PMID 25681390, Free PMC Article
    3. Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins. Guo SS, et al. Exp Cell Res, 2021 Jan 1. PMID 33253712
    4. The QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene. Logunova N, et al. PLoS Genet, 2015 Nov. PMID 26618355, Free PMC Article
    5. Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5. Abe K, et al. Mamm Genome, 2004 Apr. PMID 15112104

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins.
      Title: Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    KN motif and ankyrin repeat domain-containing protein 3
    Names
    ankyrin repeat domain 47
    ankyrin repeat domain-containing protein 47
    putative KN motif and ankyrin repeat domains 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357162.1 → NP_001344091.1  KN motif and ankyrin repeat domain-containing protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI847524, AK002623, BC037741
      Consensus CDS
      CCDS89070.1
      UniProtKB/TrEMBL
      Q6P8V1
      Related
      ENSMUSP00000133625.2, ENSMUST00000173789.2
      Conserved Domains (2) summary
      cd00204
      Location:17 → 148
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:23 → 58
      ANK; ANK repeat [structural motif]

    2. NM_030697.3 → NP_109622.1  KN motif and ankyrin repeat domain-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_109622.1

      Status: VALIDATED

      Source sequence(s)
      AI847524, AK002623
      Consensus CDS
      CCDS28630.1
      UniProtKB/Swiss-Prot
      Q9Z1P7
      UniProtKB/TrEMBL
      A0A068BIR7
      Related
      ENSMUSP00000040126.5, ENSMUST00000048560.11
      Conserved Domains (5) summary
      cd00204
      Location:601 → 733
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12075
      Location:32 → 73
      KN_motif; KN motif
      pfam12796
      Location:611 → 710
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:699 → 754
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:606 → 638
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34029497..34041894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525175.5 → XP_006525238.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006525238.1

      UniProtKB/TrEMBL
      A0A068BIR7
      Conserved Domains (5) summary
      COG0666
      Location:614 → 760
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      TIGR02231
      Location:139 → 260
      TIGR02231; conserved hypothetical protein
      sd00045
      Location:619 → 651
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:45 → 86
      KN_motif; KN motif
      pfam12796
      Location:730 → 793
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1P7.1 GenPept UniProtKB/Swiss-Prot:Q9Z1P7

    Gene LinkOut

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