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    Alg11 ALG11, alpha-1,2-mannosyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361174, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Alg11provided by RGD
    Official Full Name
    ALG11, alpha-1,2-mannosyltransferaseprovided by RGD
    Primary source
    RGD:1564725
    See related
    Ensembl:ENSRNOG00000012841 AllianceGenome:RGD:1564725
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564725
    Summary
    Predicted to enable GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity. Predicted to be involved in oligosaccharide-lipid intermediate biosynthetic process and protein N-linked glycosylation. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ip. Orthologous to human ALG11 (ALG11 alpha-1,2-mannosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 79.2), Kidney (RPKM 60.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Alg11 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (76642979..76654052, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (69940540..69951617, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (74854007..74866096, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene NIMA-related kinase 3 Neighboring gene NIMA-related kinase 5 Neighboring gene ATPase copper transporting beta Neighboring gene coiled-coil domain containing 70

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in oligosaccharide-lipid intermediate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
    Names
    asparagine-linked glycosylation 11 homolog (S. cerevisiae, alpha-1,2-mannosyltransferase)
    asparagine-linked glycosylation 11 homolog (yeast, alpha-1,2-mannosyltransferase)
    asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog
    asparagine-linked glycosylation protein 11 homolog
    NP_001101871.1
    XP_006253416.1
    XP_006253417.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108401.1 → NP_001101871.1  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

      See identical proteins and their annotated locations for NP_001101871.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473970
      UniProtKB/TrEMBL
      A6IW87, A6IW88, D3ZCQ2
      Related
      ENSRNOP00000017163.4, ENSRNOT00000017164.5
      Conserved Domains (1) summary
      cd03806
      Location:63 → 480
      GT4_ALG11-like; alpha-1,2-mannosyltransferase ALG11 and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      76642979..76654052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253354.4 → XP_006253416.1  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006253416.1

      UniProtKB/TrEMBL
      A6IW87
      Conserved Domains (1) summary
      cd03806
      Location:1 → 418
      GT4_ALG11-like; alpha-1,2-mannosyltransferase ALG11 and similar proteins

    2. XM_006253355.5 → XP_006253417.1  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006253417.1

      UniProtKB/TrEMBL
      A6IW87
      Conserved Domains (1) summary
      cd03806
      Location:1 → 418
      GT4_ALG11-like; alpha-1,2-mannosyltransferase ALG11 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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