Swi5 SWI5 recombination repair homolog (yeast) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Swi5provided by MGI
Official Full Name: SWI5 recombination repair homolog (yeast)provided by MGI
Primary source: MGI:MGI:1920181
See related: Ensembl:ENSMUSG00000044627 AllianceGenome:MGI:1920181
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1500019F05Rik; 2900010J23Rik
Summary: Involved in double-strand break repair via homologous recombination. Located in nucleus. Part of Swi5-Sfr1 complex. Is expressed in pancreas epithelium. Orthologous to human SWI5 (SWI5 homologous recombination repair protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 100.7), adrenal adult (RPKM 74.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 22.09 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (32168817..32178154, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (32278805..32288136, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Swi5-Sfr1 (S5S1) stimulates Rad51-mediated homologous recombination.
Title: Swi5-Sfr1 stimulates Rad51 recombinase filament assembly by modulating Rad51 dissociation.
Our results thus help establish the functional relevance of the trimeric RAD51-SWI5-SFR1 complex and provide insights into the mechanistic underpinnings of homology-directed DNA repair in mammalian cells.
Title: Role of the RAD51-SWI5-SFR1 Ensemble in homologous recombination.
Biophysical evidence that the mouse Swi5-Sfr1 complex has a 1:1 stoichiometry.
Title: Rad51 presynaptic filament stabilization function of the mouse Swi5-Sfr1 heterodimeric complex.
Data show that Swi5-Sfr1 is a newly identified complex required for genomic integrity in mammalian cells with a specific role in the repair of DNA strand breaks.
Title: Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (5)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Swi5-Sfr1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Swi5-Sfr1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of Swi5-Sfr1 complex	ISO Inferred from Sequence Orthology more info
part_of Swi5-Swi2 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DNA repair protein SWI5 homolog

Names: protein SAE3 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290552.1 → NP_001277481.1 DNA repair protein SWI5 homolog isoform a

See identical proteins and their annotated locations for NP_001277481.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AK013517, AL808027, BY611716

Consensus CDS

CCDS71026.1

UniProtKB/TrEMBL

A0A0A0MQ99

Related

ENSMUSP00000109027.3, ENSMUST00000113400.3

Conserved Domains (1) summary

pfam07061
Location:47 → 119

Swi5; Swi5
NM_175190.5 → NP_780399.1 DNA repair protein SWI5 homolog isoform b

See identical proteins and their annotated locations for NP_780399.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

AK013517, AL808027, BY611716

Consensus CDS

CCDS50566.1

UniProtKB/Swiss-Prot

A2AN41, Q8K3D3

UniProtKB/TrEMBL

E3WH32

Related

ENSMUSP00000139299.2, ENSMUST00000183946.8

Conserved Domains (1) summary

pfam07061
Location:13 → 88

Swi5

RNA

NR_110965.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate 5' terminal exon and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AK018775, AL808027, BY611716

Related

ENSMUST00000113397.9