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    Klhdc3 kelch domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 71765, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Klhdc3provided by MGI
    Official Full Name
    kelch domain containing 3provided by MGI
    Primary source
    MGI:MGI:2651568
    See related
    Ensembl:ENSMUSG00000063576 AllianceGenome:MGI:2651568
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Peas; 1300011D16Rik
    Summary
    Predicted to enable chromatin binding activity and ubiquitin ligase-substrate adaptor activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to act upstream of or within meiotic cell cycle. Located in chromatin and cytoplasm. Orthologous to human KLHDC3 (kelch domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 250.5), cortex adult (RPKM 57.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 22.9 cM; 17 C
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46985476..46991856, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46674550..46680930, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cullin 7 Neighboring gene STARR-seq mESC enhancer starr_42676 Neighboring gene ribosomal RNA processing 36 Neighboring gene STARR-positive B cell enhancer mm9_chr17:46817738-46818039 Neighboring gene male enhanced antigen 1 Neighboring gene protein phosphatase 2, regulatory subunit B', delta Neighboring gene STARR-positive B cell enhancer ABC_E7538 Neighboring gene peroxisomal biogenesis factor 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14(ARF) degradation. Zhang P, et al. Cell Death Differ, 2022 Apr. PMID 34743205, Free PMC Article
    2. Peas-Mea1-Ppp2r5d overlapping gene complex: a transposon mediated-gene formation in mammals. Ohinata Y, et al. DNA Res, 2003 Apr 30. PMID 12755172
    3. A novel testis-specific RAG2-like protein, Peas: its expression in pachytene spermatocyte cytoplasm and meiotic chromatin. Ohinata Y, et al. FEBS Lett, 2003 Feb 27. PMID 12606021
    4. Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis. Ohinata Y, et al. Biol Reprod, 2002 Dec. PMID 12444059
    5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14(ARF) degradation.
      Title: CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14(ARF) degradation.
    2. cloned human and mouse Peas cDNAs (hPEAS/mPeas) and analyzed their tissue and stage-specific expressions; may be involved in meiotic recombination process
      Title: A novel testis-specific RAG2-like protein, Peas: its expression in pachytene spermatocyte cytoplasm and meiotic chromatin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kelch domain-containing protein 3
    Names
    protein Peas
    testis intracellular mediator protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163729.2 → NP_001157201.2  kelch domain-containing protein 3

      See identical proteins and their annotated locations for NP_001157201.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK079082, AK141673, BY606590, CT030702
      Consensus CDS
      CCDS28834.1
      UniProtKB/Swiss-Prot
      Q3TCN9, Q3UR95, Q8VEM9, Q91XU6, Q99JH9, Q9DBG8
      UniProtKB/TrEMBL
      A0A0R4J0W0
      Related
      ENSMUSP00000128271.2, ENSMUST00000165007.9
      Conserved Domains (3) summary
      PLN02153
      Location:74 → 318
      PLN02153; epithiospecifier protein
      sd00038
      Location:128 → 173
      Kelch; KELCH repeat [structural motif]
      pfam13964
      Location:14 → 61
      Kelch_6; Kelch motif

    2. NM_027910.3 → NP_082186.2  kelch domain-containing protein 3

      See identical proteins and their annotated locations for NP_082186.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK004964, AK141673, BE945284, CF169399
      Consensus CDS
      CCDS28834.1
      UniProtKB/Swiss-Prot
      Q3TCN9, Q3UR95, Q8VEM9, Q91XU6, Q99JH9, Q9DBG8
      UniProtKB/TrEMBL
      A0A0R4J0W0
      Related
      ENSMUSP00000071743.6, ENSMUST00000071841.7
      Conserved Domains (3) summary
      PLN02153
      Location:74 → 318
      PLN02153; epithiospecifier protein
      sd00038
      Location:128 → 173
      Kelch; KELCH repeat [structural motif]
      pfam13964
      Location:14 → 61
      Kelch_6; Kelch motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      46985476..46991856 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524943.5 → XP_006525006.1  kelch domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006525006.1

      UniProtKB/Swiss-Prot
      Q3TCN9, Q3UR95, Q8VEM9, Q91XU6, Q99JH9, Q9DBG8
      UniProtKB/TrEMBL
      A0A0R4J0W0
      Conserved Domains (3) summary
      PLN02153
      Location:74 → 318
      PLN02153; epithiospecifier protein
      sd00038
      Location:128 → 173
      Kelch; KELCH repeat [structural motif]
      pfam13964
      Location:14 → 61
      Kelch_6; Kelch motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VEM9.1 GenPept UniProtKB/Swiss-Prot:Q8VEM9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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