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    Slc7a7 solute carrier family 7 member 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83509, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Slc7a7provided by RGD
    Official Full Name
    solute carrier family 7 member 7provided by RGD
    Primary source
    RGD:619902
    See related
    Ensembl:ENSRNOG00000010296 AllianceGenome:RGD:619902
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    y+LAT1
    Summary
    Predicted to enable L-amino acid transmembrane transporter activity and basic amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport and regulation of arginine metabolic process. Predicted to be located in basolateral plasma membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in lysinuric protein intolerance. Orthologous to human SLC7A7 (solute carrier family 7 member 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 446.1), Spleen (RPKM 61.8) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    15p13
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (31792122..31852732, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (27822088..27873121, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33013346..33059733, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352920 Neighboring gene OXA1L, mitochondrial inner membrane protein Neighboring gene mitochondrial ribosomal protein L52 Neighboring gene matrix metallopeptidase 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of SLC7A7, encoding y+LAT-1, as the lysinuric protein intolerance gene. Torrents D, et al. Nat Genet, 1999 Mar. PMID 10080182
    2. Up-regulation of L type amino acid transporter 1 after spinal cord injury in rats. Toyooka T, et al. Acta Neurochir Suppl, 2008. PMID 19388351
    3. Five novel SLC7A7 variants and y+L gene-expression pattern in cultured lymphoblasts from Japanese patients with lysinuric protein intolerance. Shoji Y, et al. Hum Mutat, 2002 Nov. PMID 12402335
    4. Effects of sodium nitroprusside and other smooth muscle relaxants on cyclic GMP formation in smooth muscle and platelets. Böhme E, et al. Adv Cyclic Nucleotide Res, 1978. PMID 27075
    5. Slc7a7 disruption causes fetal growth retardation by downregulating Igf1 in the mouse model of lysinuric protein intolerance. Sperandeo MP, et al. Am J Physiol Cell Physiol, 2007 Jul. PMID 17376816

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-arginine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables basic amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables basic amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-arginine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-arginine transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in L-leucine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-leucine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within basic amino acid transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of arginine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of arginine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Y+L amino acid transporter 1
    Names
    solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
    y(+)L-type amino acid transporter 1
    y+LAT-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031341.2 → NP_112631.1  Y+L amino acid transporter 1

      See identical proteins and their annotated locations for NP_112631.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q9QZ66, Q9R0S5
      UniProtKB/TrEMBL
      A6KGS5, A6KGT1
      Related
      ENSRNOP00000014391.3, ENSRNOT00000014391.6
      Conserved Domains (1) summary
      TIGR00911
      Location:24 → 496
      2A0308; L-type amino acid transporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      31792122..31852732 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274696.1 → XP_063130766.1  Y+L amino acid transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9QZ66, Q9R0S5
      UniProtKB/TrEMBL
      A6KGT1

    2. XM_008770705.4 → XP_008768927.1  Y+L amino acid transporter 1 isoform X1

      See identical proteins and their annotated locations for XP_008768927.1

      UniProtKB/Swiss-Prot
      Q9QZ66, Q9R0S5
      UniProtKB/TrEMBL
      A6KGS5, A6KGT1
      Conserved Domains (1) summary
      TIGR00911
      Location:24 → 496
      2A0308; L-type amino acid transporter

    3. XM_039093692.2 → XP_038949620.1  Y+L amino acid transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9QZ66, Q9R0S5
      UniProtKB/TrEMBL
      A6KGS5, A6KGT1
      Conserved Domains (1) summary
      TIGR00911
      Location:24 → 496
      2A0308; L-type amino acid transporter

    4. XM_039093693.2 → XP_038949621.1  Y+L amino acid transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9QZ66, Q9R0S5
      UniProtKB/TrEMBL
      A6KGS5, A6KGT1
      Conserved Domains (1) summary
      TIGR00911
      Location:24 → 496
      2A0308; L-type amino acid transporter

    5. XM_039093695.1 → XP_038949623.1  Y+L amino acid transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9QZ66, Q9R0S5
      UniProtKB/TrEMBL
      A6KGS5, A6KGT1
      Conserved Domains (1) summary
      TIGR00911
      Location:24 → 496
      2A0308; L-type amino acid transporter

    6. XM_039093696.2 → XP_038949624.1  Y+L amino acid transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9QZ66, Q9R0S5
      UniProtKB/TrEMBL
      A6KGS5, A6KGT1
      Conserved Domains (1) summary
      TIGR00911
      Location:24 → 496
      2A0308; L-type amino acid transporter

    7. XM_039093694.2 → XP_038949622.1  Y+L amino acid transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9QZ66, Q9R0S5
      UniProtKB/TrEMBL
      A6KGS5, A6KGT1
      Conserved Domains (1) summary
      TIGR00911
      Location:24 → 496
      2A0308; L-type amino acid transporter

    8. XM_006252020.5 → XP_006252082.1  Y+L amino acid transporter 1 isoform X1

      See identical proteins and their annotated locations for XP_006252082.1

      UniProtKB/Swiss-Prot
      Q9QZ66, Q9R0S5
      UniProtKB/TrEMBL
      A6KGS5, A6KGT1
      Conserved Domains (1) summary
      TIGR00911
      Location:24 → 496
      2A0308; L-type amino acid transporter

    9. XM_006252023.5 → XP_006252085.1  Y+L amino acid transporter 1 isoform X1

      See identical proteins and their annotated locations for XP_006252085.1

      UniProtKB/Swiss-Prot
      Q9QZ66, Q9R0S5
      UniProtKB/TrEMBL
      A6KGS5, A6KGT1
      Conserved Domains (1) summary
      TIGR00911
      Location:24 → 496
      2A0308; L-type amino acid transporter

    10. XM_039093698.2 → XP_038949626.1  Y+L amino acid transporter 1 isoform X2

      Conserved Domains (1) summary
      TIGR00911
      Location:2 → 269
      2A0308; L-type amino acid transporter

    11. XM_039093699.2 → XP_038949627.1  Y+L amino acid transporter 1 isoform X3

      Conserved Domains (1) summary
      TIGR00911
      Location:27 → 263
      2A0308; L-type amino acid transporter

    12. XM_063274698.1 → XP_063130768.1  Y+L amino acid transporter 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R0S5.1 GenPept UniProtKB/Swiss-Prot:Q9R0S5

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