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    ANGPT2 angiopoietin 2 [ Homo sapiens (human) ]

    Gene ID: 285, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ANGPT2provided by HGNC
    Official Full Name
    angiopoietin 2provided by HGNC
    Primary source
    HGNC:HGNC:485
    See related
    Ensembl:ENSG00000091879 MIM:601922; AllianceGenome:HGNC:485
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANG2; AGPT2; LMPHM10
    Summary
    This gene belongs to the angiopoietin family of growth factors. The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. Angiopoietin 2 is upregulated in multiple inflammatory diseases and is implicated in the direct control of inflammation-related signaling pathways. The encoded protein affects angiogenesis during embryogenesis and tumorigenesis, disrupts the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell apoptosis. This gene serves a prognostic biomarker for acute respiratory distress syndrome. [provided by RefSeq, Aug 2020]
    Expression
    Broad expression in placenta (RPKM 6.2), urinary bladder (RPKM 5.1) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    8p23.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (6499632..6563245, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (6254102..6317682, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (6357153..6420766, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18880 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18881 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26946 Neighboring gene MCPH1 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 14576 Neighboring gene microcephalin 1 Neighboring gene adenylate kinase isoenzyme 6-like Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:6385720-6386919 Neighboring gene Sharpr-MPRA regulatory region 12768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:6419583-6420108 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:6420109-6420635 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:6434138-6434684 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:6436241-6436413 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_103492 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:6446215-6446714 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:6450530-6451446 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:6451447-6452362 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:6456108-6457307 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:6459927-6460426 Neighboring gene NANOG hESC enhancer GRCh37_chr8:6473596-6474097 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:6481178-6481678 Neighboring gene MCPH1 antisense RNA 1 Neighboring gene microRNA 8055 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:6505663-6506862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26951 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26952 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18884 Neighboring gene protein tyrosine phosphatase non-receptor type 4 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18885 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Role of Genetic Polymorphism and Expression of Angiopoietin-2 in Patients with Primary Liver Cancer Among the Southeastern Chinese Hans Population. Wang B, et al. Genet Test Mol Biomarkers, 2023 Jun. PMID 37382908
    2. Serum Angiopoietin-2 Predicts the Occurrence and Recurrence of Hepatocellular Carcinoma after Direct-Acting Antiviral Therapy for Hepatitis C. Kawagishi N, et al. Viruses, 2023 Jan 7. PMID 36680221, Free PMC Article
    3. Immunoregulation and clinical significance of neutrophils/NETs-ANGPT2 in tumor microenvironment of gastric cancer. Yang S, et al. Front Immunol, 2022. PMID 36172371, Free PMC Article
    4. The impact of Angiopoietin-2 genetic polymorphisms on susceptibility for malignant breast neoplasms. Hu GN, et al. Sci Rep, 2022 Aug 25. PMID 36008514, Free PMC Article
    5. Reduced Angiopoietin Factor 2 Levels Are Correlated with Better Cardiac Function and Prognosis in Valvular Heart Disease. Hou J, et al. Braz J Cardiovasc Surg, 2023 Feb 10. PMID 35657310, Free PMC Article

    See all (512) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Involvement of Angiopoietin 2 and vascular endothelial growth factor in uveitis.
      Title: Involvement of Angiopoietin 2 and vascular endothelial growth factor in uveitis.
    2. Serum Angiopoietin-2 level increase differs between polytraumatized patients with and without central nervous system injuries.
      Title: Serum Angiopoietin-2 level increase differs between polytraumatized patients with and without central nervous system injuries.
    3. miR-221-3p targets Ang-2 to inhibit the transformation of HCMECs to tip cells.
      Title: miR-221-3p targets Ang-2 to inhibit the transformation of HCMECs to tip cells.
    4. Diagnostic and prognostic value of Ang-2 in ARDS: a systemic review and meta-analysis.
      Title: Diagnostic and prognostic value of Ang-2 in ARDS: a systemic review and meta-analysis.
    5. The possible dual role of Ang-2 in the prognosis of pancreatic cancer.
      Title: The possible dual role of Ang-2 in the prognosis of pancreatic cancer.
    6. Angiopoietin-2 blockade suppresses growth of liver metastases from pancreatic neuroendocrine tumors by promoting T cell recruitment.
      Title: Angiopoietin-2 blockade suppresses growth of liver metastases from pancreatic neuroendocrine tumors by promoting T cell recruitment.
    7. Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis.
      Title: Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis.
    8. Hypoxia-Inducible Factor-1alpha in SM22alpha-Expressing Cells Modulates Alveolarization.
      Title: Hypoxia-Inducible Factor-1α in SM22α-Expressing Cells Modulates Alveolarization.
    9. Role of Genetic Polymorphism and Expression of Angiopoietin-2 in Patients with Primary Liver Cancer Among the Southeastern Chinese Hans Population.
      Title: Role of Genetic Polymorphism and Expression of Angiopoietin-2 in Patients with Primary Liver Cancer Among the Southeastern Chinese Hans Population.
    10. von Willebrand factor binds to angiopoietin-2 within endothelial cells and after release from Weibel-Palade bodies.
      Title: von Willebrand factor binds to angiopoietin-2 within endothelial cells and after release from Weibel-Palade bodies.
    Submit: New GeneRIF Correction See all GeneRIFs (482)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Lymphatic malformation 10
    MedGen: C5543531 OMIM: 619369 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Tie signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Tie signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in animal organ regeneration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in germ cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glomerulus vasculature development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in maternal process involved in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of blood vessel endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of positive chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to glucose IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    angiopoietin-2
    Names
    Tie2-ligand
    angiopoietin-2B
    angiopoietin-2a

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029483.1 RefSeqGene

      Range
      5019..68632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001118887.2 → NP_001112359.1  angiopoietin-2 isoform b precursor

      See identical proteins and their annotated locations for NP_001112359.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1, resulting in an isoform (b) that lacks an internal aa compared to isoform a.
      Source sequence(s)
      AC018398, BC022490, BC126200, DA829327
      Consensus CDS
      CCDS47762.1
      UniProtKB/TrEMBL
      B2R6E3
      Related
      ENSP00000486858.2, ENST00000629816.3
      Conserved Domains (2) summary
      smart00186
      Location:279 → 493
      FBG; Fibrinogen-related domains (FReDs)
      cl19219
      Location:138 → 243
      DUF342; Protein of unknown function (DUF342)

    2. NM_001118888.2 → NP_001112360.1  angiopoietin-2 isoform c precursor

      See identical proteins and their annotated locations for NP_001112360.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1, resulting in an isoform (c) that has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC018398, AF187858, AK290070, DA829327
      Consensus CDS
      CCDS47761.1
      UniProtKB/TrEMBL
      B2R6E3
      Related
      ENSP00000343517.6, ENST00000338312.10
      Conserved Domains (2) summary
      smart00186
      Location:228 → 442
      FBG; Fibrinogen-related domains (FReDs)
      cl19252
      Location:122 → 187
      MreC; rod shape-determining protein MreC

    3. NM_001147.3 → NP_001138.1  angiopoietin-2 isoform a precursor

      See identical proteins and their annotated locations for NP_001138.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC018398, AK290070, BC126200, DA829327
      Consensus CDS
      CCDS5958.1
      UniProtKB/Swiss-Prot
      A0AV38, A8K205, B7ZLM7, O15123, Q9NRR7, Q9P2Y7
      UniProtKB/TrEMBL
      B2R6E3
      Related
      ENSP00000314897.5, ENST00000325203.9
      Conserved Domains (2) summary
      smart00186
      Location:280 → 494
      FBG; Fibrinogen-related domains (FReDs)
      cl25732
      Location:78 → 295
      SMC_N; RecF/RecN/SMC N terminal domain

    4. NM_001386335.1 → NP_001373264.1  angiopoietin-2 isoform d precursor

      Status: REVIEWED

      Source sequence(s)
      AC018398
      UniProtKB/TrEMBL
      B2R6E3
      Conserved Domains (2) summary
      smart00186
      Location:227 → 441
      FBG; Fibrinogen-related domains (FReDs)
      pfam15921
      Location:46 → 242
      CCDC158; Coiled-coil domain-containing protein 158

    5. NM_001386336.1 → NP_001373265.1  angiopoietin-2 isoform e precursor

      Status: REVIEWED

      Source sequence(s)
      AC018398
      UniProtKB/TrEMBL
      E7EVQ3
      Conserved Domains (2) summary
      smart00186
      Location:280 → 403
      FBG; Fibrinogen-related domains (FReDs)
      pfam15921
      Location:78 → 295
      CCDC158; Coiled-coil domain-containing protein 158

    6. NM_001386337.1 → NP_001373266.1  angiopoietin-2 isoform f precursor

      Status: REVIEWED

      Source sequence(s)
      AC018398
      UniProtKB/TrEMBL
      E7EVQ3
      Conserved Domains (2) summary
      smart00186
      Location:279 → 402
      FBG; Fibrinogen-related domains (FReDs)
      pfam15921
      Location:78 → 294
      CCDC158; Coiled-coil domain-containing protein 158

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      6499632..6563245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      6254102..6317682 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15123.1 GenPept UniProtKB/Swiss-Prot:O15123

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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