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    Cd2bp2 Cd2 (cytoplasmic tail) binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293505, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cd2bp2provided by RGD
    Official Full Name
    Cd2 (cytoplasmic tail) binding protein 2provided by RGD
    Primary source
    RGD:1311741
    See related
    Ensembl:ENSRNOG00000017201 AllianceGenome:RGD:1311741
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ribonucleoprotein complex binding activity. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be part of U5 snRNP. Predicted to colocalize with nuclear speck. Orthologous to human CD2BP2 (CD2 cytoplasmic tail binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 138.2), Brain (RPKM 132.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q37
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191239899..191244395, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181809399..181815269, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198635445..198641195, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene sialophorin Neighboring gene uncharacterized LOC134483874 Neighboring gene TBC1 domain family, member 10b Neighboring gene myosin light chain 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation. Laggerbauer B, et al. RNA, 2005 May. PMID 15840814, Free PMC Article
    2. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    NOT part_of U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U5 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CD2 antigen cytoplasmic tail-binding protein 2
    Names
    CD2 antigen (cytoplasmic tail) binding protein 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106297.2 → NP_001099767.1  CD2 antigen cytoplasmic tail-binding protein 2

      See identical proteins and their annotated locations for NP_001099767.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168174
      UniProtKB/TrEMBL
      B4F786, F7FJA7
      Related
      ENSRNOP00000023285.4, ENSRNOT00000023285.6
      Conserved Domains (1) summary
      cd00072
      Location:279 → 339
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      191239899..191244395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107471.2 → XP_038963399.1  CD2 antigen cytoplasmic tail-binding protein 2 isoform X2

      Conserved Domains (1) summary
      cd00072
      Location:279 → 346
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

    2. XM_063286236.1 → XP_063142306.1  CD2 antigen cytoplasmic tail-binding protein 2 isoform X1

    3. XM_063286262.1 → XP_063142332.1  CD2 antigen cytoplasmic tail-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      B4F786, F7FJA7

    4. XM_039107484.2 → XP_038963412.1  CD2 antigen cytoplasmic tail-binding protein 2 isoform X2

      Conserved Domains (1) summary
      cd00072
      Location:279 → 346
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

    5. XM_063286246.1 → XP_063142316.1  CD2 antigen cytoplasmic tail-binding protein 2 isoform X1

    6. XM_006230252.5 → XP_006230314.1  CD2 antigen cytoplasmic tail-binding protein 2 isoform X3

      See identical proteins and their annotated locations for XP_006230314.1

      UniProtKB/TrEMBL
      B4F786, F7FJA7
      Conserved Domains (1) summary
      cd00072
      Location:279 → 339
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

    7. XM_039107481.2 → XP_038963409.1  CD2 antigen cytoplasmic tail-binding protein 2 isoform X2

      Conserved Domains (1) summary
      cd00072
      Location:279 → 346
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

    8. XM_063286241.1 → XP_063142311.1  CD2 antigen cytoplasmic tail-binding protein 2 isoform X1

    9. XM_039107486.2 → XP_038963414.1  CD2 antigen cytoplasmic tail-binding protein 2 isoform X2

      Conserved Domains (1) summary
      cd00072
      Location:279 → 346
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

    10. XM_063286266.1 → XP_063142336.1  CD2 antigen cytoplasmic tail-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      B4F786, F7FJA7

    11. XM_063286247.1 → XP_063142317.1  CD2 antigen cytoplasmic tail-binding protein 2 isoform X1

    12. XM_063286269.1 → XP_063142339.1  CD2 antigen cytoplasmic tail-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      B4F786, F7FJA7

    13. XM_063286273.1 → XP_063142343.1  CD2 antigen cytoplasmic tail-binding protein 2 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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