Clec3b C-type lectin domain family 3, member b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clec3bprovided by MGI
Official Full Name: C-type lectin domain family 3, member bprovided by MGI
Primary source: MGI:MGI:104540
See related: Ensembl:ENSMUSG00000025784 AllianceGenome:MGI:104540
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tna
Summary: Predicted to enable calcium ion binding activity; heparin binding activity; and kringle domain binding activity. Involved in positive regulation of plasminogen activation. Acts upstream of or within ossification and skeletal system development. Located in cytoplasm. Is expressed in several structures, including genitourinary system; gut; serum; skeletal musculature; and spinal cord. Used to study Scheuermann's disease. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human CLEC3B (C-type lectin domain family 3 member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 244.6), mammary gland adult (RPKM 136.3) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F4; 9 73.91 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (122980011..122986497)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (123150946..123157432)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Delayed tendon healing after injury in tetranectin-deficient mice.
Title: Delayed tendon healing after injury in tetranectin-deficient mice.
This study demonstrates the adipogenic function of Tetranectin, which is dependent on the plasminogen binding domain as its functional domain.
Title: Adipogenic function of mouse tetranectin and identification of its functional domain.
Tetranectin knockdown induces neuronal cell death.
Title: Tetranectin gene deletion induces Parkinson's disease by enhancing neuronal apoptosis.
tetranectin could have a role in the positive regulation at the early stage of the fracture-healing process.
Title: Delayed fracture healing in tetranectin-deficient mice.
Tetranectin may play an important role in the survival of islets in the liver after islet transplantation.
Title: In the search of potential human islet stem cells: is tetranectin showing us the way?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

Clec3b (e-PCR), detects polymorphism
- UniSTS:519415

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	TAS Traceable Author Statement more info	PubMed
enables carbohydrate binding	TAS Traceable Author Statement more info	PubMed
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables kringle domain binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in bone mineralization	IBA Inferred from Biological aspect of Ancestor more info
involved_in bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in ossification	IBA Inferred from Biological aspect of Ancestor more info
involved_in ossification	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of plasminogen activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	TAS Traceable Author Statement more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	TAS Traceable Author Statement more info	PubMed
located_in granular component	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tetranectin

Names: TN; plasminogen kringle 4-binding protein; tetranectin (plasminogen binding protein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011606.2 → NP_035736.2 tetranectin precursor

See identical proteins and their annotated locations for NP_035736.2

Status: VALIDATED

Source sequence(s)

BC035043, BY114395

Consensus CDS

CCDS23656.1

UniProtKB/Swiss-Prot

P43025

UniProtKB/TrEMBL

Q8CFZ6

Related

ENSMUSP00000026890.5, ENSMUST00000026890.6

Conserved Domains (1) summary

cd03596
Location:71 → 199

CLECT_tetranectin_like; C-type lectin-like domain (CTLD) of the type found in the tetranectin (TN), cartilage derived C-type lectin (CLECSF1), and stem cell growth factor (SCGF)