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    Txndc12 thioredoxin domain containing 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298370, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Txndc12provided by RGD
    Official Full Name
    thioredoxin domain containing 12provided by RGD
    Primary source
    RGD:1305960
    See related
    Ensembl:ENSRNOG00000008090 AllianceGenome:RGD:1305960
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305960
    Summary
    Predicted to enable protein-disulfide reductase activity. Predicted to be involved in negative regulation of cell death. Predicted to act upstream of or within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Orthologous to human TXNDC12 (thioredoxin domain containing 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 300.8), Heart (RPKM 275.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (128815471..128841574)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (123587854..123612886)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (128450830..128475858)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene coiled-coil and C2 domain containing 1B Neighboring gene zinc finger FYVE-type containing 9 Neighboring gene ribosomal protein L9, pseudogene 8 Neighboring gene basic transcription factor 3-like 4 Neighboring gene KTI12 chromatin associated Neighboring gene RAB3B, member RAS oncogene family Neighboring gene uncharacterized LOC134486965 Neighboring gene RNA, U6 small nuclear 304

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ERp16, an endoplasmic reticulum-resident thiol-disulfide oxidoreductase: biochemical properties and role in apoptosis induced by endoplasmic reticulum stress. Jeong W, et al. J Biol Chem, 2008 Sep 12. PMID 18628206, Free PMC Article
    2. ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins. Knoblach B, et al. Mol Cell Proteomics, 2003 Oct. PMID 12930873
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ERp16 mediates disulfide bond formation in the ER and plays an important role in cellular defense against prolonged ER stress
      Title: ERp16, an endoplasmic reticulum-resident thiol-disulfide oxidoreductase: biochemical properties and role in apoptosis induced by endoplasmic reticulum stress.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-disulfide reductase (glutathione) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-disulfide reductase (glutathione) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-disulfide reductase (glutathione) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-disulfide reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    thioredoxin domain-containing protein 12
    Names
    thioredoxin domain containing 12 (endoplasmic reticulum)
    NP_001094310.1
    XP_063143462.1
    XP_063143463.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100840.1 → NP_001094310.1  thioredoxin domain-containing protein 12 precursor

      See identical proteins and their annotated locations for NP_001094310.1

      Status: VALIDATED

      Source sequence(s)
      BC100255, CV117277
      UniProtKB/Swiss-Prot
      Q498E0
      UniProtKB/TrEMBL
      A6JYW6, B0BN97
      Related
      ENSRNOP00000094562.1, ENSRNOT00000100650.1
      Conserved Domains (1) summary
      cd02959
      Location:34 → 150
      ERp19; Endoplasmic reticulum protein 19 (ERp19) family; ERp19 is also known as ERp18, a protein located in the ER containing one redox active TRX domain. Denaturation studies indicate that the reduced form is more stable than the oxidized form, suggesting that ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      128815471..128841574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287393.1 → XP_063143463.1  thioredoxin domain-containing protein 12 isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q4K2

    2. XM_063287392.1 → XP_063143462.1  thioredoxin domain-containing protein 12 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQ94
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q498E0.2 GenPept UniProtKB/Swiss-Prot:Q498E0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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