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    Orc1 origin recognition complex, subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313479, updated on 2-May-2024

    Summary

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    Official Symbol
    Orc1provided by RGD
    Official Full Name
    origin recognition complex, subunit 1provided by RGD
    Primary source
    RGD:631435
    See related
    Ensembl:ENSRNOG00000008841 AllianceGenome:RGD:631435
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Orc1l
    Summary
    Enables chromatin binding activity. Involved in positive regulation of G0 to G1 transition and positive regulation of smooth muscle cell proliferation. Located in nucleus. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 1. Orthologous to human ORC1 (origin recognition complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 55.4), Spleen (RPKM 48.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q34
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (128552975..128581943)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (123324273..123348375)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (128186651..128212901)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene terminal uridylyl transferase 4 Neighboring gene uncharacterized LOC134486964 Neighboring gene pre-mRNA processing factor 38A Neighboring gene coiled-coil and C2 domain containing 1B Neighboring gene zinc finger FYVE-type containing 9 Neighboring gene ribosomal protein L9, pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RNA interference targeting ORC1 gene suppresses the proliferation of vascular smooth muscle cells in rats. Shu MQ, et al. Exp Mol Pathol, 2008 Jun. PMID 18499104
    2. Binding of AlF-C, an Orc1-binding transcriptional regulator, enhances replicator activity of the rat aldolase B origin. Minami H, et al. Mol Cell Biol, 2006 Dec. PMID 16982680, Free PMC Article
    3. Novel splicing variant of mouse Orc1 is deficient in nuclear translocation and resistant for proteasome-mediated degradation. Miyake Y, et al. J Biol Chem, 2005 Apr 1. PMID 15634681
    4. Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals. Natale DA, et al. EMBO J, 2000 Jun 1. PMID 10835370, Free PMC Article
    5. ATP-dependent assembly of the human origin recognition complex. Siddiqui K, et al. J Biol Chem, 2007 Nov 2. PMID 17716973

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of G0 to G1 transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear origin of replication recognition complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear origin of replication recognition complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear origin of replication recognition complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear origin of replication recognition complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of origin recognition complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    origin recognition complex subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177931.2 → NP_808792.1  origin recognition complex subunit 1

      See identical proteins and their annotated locations for NP_808792.1

      Status: PROVISIONAL

      Source sequence(s)
      AB105378
      UniProtKB/Swiss-Prot
      Q80Z32
      UniProtKB/TrEMBL
      A0A8I6A918
      Conserved Domains (5) summary
      cd04719
      Location:43 → 169
      BAH_Orc1p_animal; BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC ...
      TIGR02928
      Location:482 → 814
      TIGR02928; orc1/cdc6 family replication initiation protein
      pfam09079
      Location:765 → 838
      Cdc6_C; CDC6, C terminal
      pfam13191
      Location:491 → 541
      AAA_16; AAA ATPase domain
      cl21455
      Location:517 → 662
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      128552975..128581943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238515.5 → XP_006238577.1  origin recognition complex subunit 1 isoform X1

      See identical proteins and their annotated locations for XP_006238577.1

      UniProtKB/TrEMBL
      A0A8I6A918, A6JYV4
      Related
      ENSRNOP00000012492.6
      Conserved Domains (5) summary
      cd04719
      Location:43 → 169
      BAH_Orc1p_animal; BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC ...
      TIGR02928
      Location:482 → 814
      TIGR02928; orc1/cdc6 family replication initiation protein
      pfam09079
      Location:765 → 838
      Cdc6_C; CDC6, C terminal
      pfam13191
      Location:491 → 541
      AAA_16; AAA ATPase domain
      cl21455
      Location:517 → 662
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_063287715.1 → XP_063143785.1  origin recognition complex subunit 1 isoform X3

    3. XM_039109968.2 → XP_038965896.2  origin recognition complex subunit 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80Z32.1 GenPept UniProtKB/Swiss-Prot:Q80Z32

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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