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    Slc34a3 solute carrier family 34 member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246234, updated on 13-Apr-2024

    Summary

    Official Symbol
    Slc34a3provided by RGD
    Official Full Name
    solute carrier family 34 member 3provided by RGD
    Primary source
    RGD:708551
    See related
    Ensembl:ENSRNOG00000010451 AllianceGenome:RGD:708551
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables sodium:phosphate symporter activity. Involved in response to magnesium ion; response to nutrient levels; and sodium-dependent phosphate transport. Located in apical plasma membrane; brush border membrane; and cytoplasmic vesicle. Human ortholog(s) of this gene implicated in hereditary hypophosphatemic rickets with hypercalciuria. Orthologous to human SLC34A3 (solute carrier family 34 member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 259.6) See more
    Orthologs
    NEW
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    Genomic context

    Location:
    3p13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28442455..28447997, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8044294..8050034, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2448391..2454019, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene sperm-tail PG-rich repeat containing 3 Neighboring gene ciliary microtubule inner protein 2A Neighboring gene tubulin, beta 4B class IVb Neighboring gene uncharacterized LOC120101506 Neighboring gene ring finger protein 224 Neighboring gene cysteine rich tail 1 Neighboring gene ring finger protein 208

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables sodium:phosphate symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sodium:phosphate symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sodium:phosphate symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables sodium:phosphate symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in intracellular phosphate ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular phosphate ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular phosphate ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphate ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phosphate ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphate ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to magnesium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium-dependent phosphate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium-dependent phosphate transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium-dependent phosphate transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in brush border IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in brush border membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    sodium-dependent phosphate transport protein 2C
    Names
    Na(+)-dependent phosphate cotransporter 2C
    Na(+)/Pi cotransporter 2C
    Na+/Pi-cotransporter type IIc
    naPi-2c
    sodium-phosphate transport protein 2C
    sodium/phosphate cotransporter 2C
    solute carrier family 34 (sodium phosphate), member 3
    solute carrier family 34 (type II sodium/phosphate contransporter), member 3
    solute carrier family 34 (type II sodium/phosphate cotransporter), member 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139338.3NP_647554.2  sodium-dependent phosphate transport protein 2C

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q8K4R8
      UniProtKB/TrEMBL
      A6JT20, G3V7E1
      Related
      ENSRNOP00000014060.3, ENSRNOT00000014060.7
      Conserved Domains (1) summary
      TIGR01013
      Location:79565
      2a58; Phosphate:Na+ Symporter (PNaS) Family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      28442455..28447997 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104250.2XP_038960178.1  sodium-dependent phosphate transport protein 2C isoform X2

      UniProtKB/Swiss-Prot
      Q8K4R8
      UniProtKB/TrEMBL
      A6JT20, G3V7E1
      Conserved Domains (1) summary
      TIGR01013
      Location:79565
      2a58; Phosphate:Na+ Symporter (PNaS) Family
    2. XM_063283081.1XP_063139151.1  sodium-dependent phosphate transport protein 2C isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7V6