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    Dynlt2a1 dynein light chain Tctex-type 2A1 [ Mus musculus (house mouse) ]

    Gene ID: 21647, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Dynlt2a1provided by MGI
    Official Full Name
    dynein light chain Tctex-type 2A1provided by MGI
    Primary source
    MGI:MGI:98642
    See related
    Ensembl:ENSMUSG00000079707 AllianceGenome:MGI:98642
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LC2; Tcte3; Dynlt2; Tcte-3; Tctex2; Tctex4; Tctex-2; Tctex-4; D17Leh117c
    Summary
    This gene is one of three genes with a very high degree of similarity to each other within a 77 kb genomic span on Chromosome 17 A2. This gene is the most distal copy of the three genes. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis adult (RPKM 436.0) See more
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    Genomic context

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    Location:
    17 A2; 17 8.95 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (15233025..15261821, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (15027154..15041559, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ER membrane associated RNA degradation like 2 Neighboring gene STARR-seq mESC enhancer starr_41898 Neighboring gene predicted gene 3255 Neighboring gene dynein light chain Tctex-type 2A2 Neighboring gene ER membrane associated RNA degradation like 1 Neighboring gene predicted gene, 52298 Neighboring gene STARR-seq mESC enhancer starr_41899 Neighboring gene ER membrane associated RNA degradation Neighboring gene predicted gene, 53990 Neighboring gene STARR-seq mESC enhancer starr_41900 Neighboring gene predicted gene, 35343

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Disruption of the murine dynein light chain gene Tcte3-3 results in asthenozoospermia. Rashid S, et al. Reproduction, 2010 Jan. PMID 19778998
    2. The protein of a new gene, Tctex4, interacts with protein kinase CK2beta subunit and is highly expressed in mouse testis. Bai X, et al. Biochem Biophys Res Commun, 2003 Jul 18. PMID 12849985
    3. Identification of the human ortholog of the t-complex-encoded protein TCTE3 and evaluation as a candidate gene for primary ciliary dyskinesia. Neesen J, et al. Cytogenet Genome Res, 2002. PMID 12584439
    4. Assignment of the human homologue of the mouse t-complex gene TCTE3 to human chromosome 6q27. Rappold GA, et al. Genomics, 1992 Aug. PMID 1505969
    5. Tctex2: a sperm tail surface protein mapping to the t-complex. Huw LY, et al. Dev Biol, 1995 Jul. PMID 7601308

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results support a role of Tcte3-3 in generation of sperm motility as well as in male germ cell differentiation
      Title: Disruption of the murine dynein light chain gene Tcte3-3 results in asthenozoospermia.
    2. Data show that casein kinase 2beta interacts specifically with Tctex4 both in a yeast two-hybrid system and in an in vitro interaction assay.
      Title: The protein of a new gene, Tctex4, interacts with protein kinase CK2beta subunit and is highly expressed in mouse testis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule-based movement IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynein light chain Tctex-type protein 2
    Names
    T-complex testis-specific protein 2
    T-complex testis-specific protein 3
    T-complex-associated testis-expressed protein 3
    T-complex-associated testis-expressed protein 4
    t-complex testis-expressed 4
    t-complex-associated testis expressed 3
    tctex1 domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011560.3 → NP_035690.2  dynein light chain Tctex-type protein 2 isoform 1

      See identical proteins and their annotated locations for NP_035690.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AK006370, BU919334, CN835332, CN842925
      Consensus CDS
      CCDS28408.1
      UniProtKB/TrEMBL
      A0A0R4J284
      Related
      ENSMUSP00000036704.7, ENSMUST00000040746.8
      Conserved Domains (1) summary
      pfam03645
      Location:94 → 189
      Tctex-1; Tctex-1 family

    2. NM_198104.2 → NP_932772.1  dynein light chain Tctex-type protein 2 isoform 2

      See identical proteins and their annotated locations for NP_932772.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2) that has a shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AY172988, BU919334, CN835332, CN842925
      Consensus CDS
      CCDS28409.1
      UniProtKB/Swiss-Prot
      P11985
      Related
      ENSMUSP00000095010.5, ENSMUST00000097398.12
      Conserved Domains (1) summary
      pfam03645
      Location:37 → 137
      Tctex-1; Tctex-1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      15233025..15261821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160473.1 → XP_036016366.1  dynein light chain Tctex-type protein 2 isoform X4

    2. XM_036160470.1 → XP_036016363.1  dynein light chain Tctex-type protein 2 isoform X1

    3. XM_036160471.1 → XP_036016364.1  dynein light chain Tctex-type protein 2 isoform X2

    4. XM_036160472.1 → XP_036016365.1  dynein light chain Tctex-type protein 2 isoform X3

    RNA

    1. XR_004939506.1 RNA Sequence

    2. XR_004939508.1 RNA Sequence

    3. XR_004939507.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11985.2 GenPept UniProtKB/Swiss-Prot:P11985

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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