Zswim6 zinc finger SWIM-type containing 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zswim6provided by MGI
Official Full Name: zinc finger SWIM-type containing 6provided by MGI
Primary source: MGI:MGI:1914513
See related: Ensembl:ENSMUSG00000032846 AllianceGenome:MGI:1914513
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1577; 2900036G02Rik
Summary: Predicted to enable zinc ion binding activity. Involved in striatal medium spiny neuron differentiation. Acts upstream of or within neuron projection morphogenesis and regulation of neuron migration. Located in stereocilium. Is expressed in several structures, including forebrain; hair outer root sheath; jaw; midbrain mantle layer; and sensory organ. Human ortholog(s) of this gene implicated in acromelic frontonasal dysostosis. Orthologous to human ZSWIM6 (zinc finger SWIM-type containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 11.2), CNS E14 (RPKM 10.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D2.1; 13 59.39 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (107861152..108026598, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (107724617..107890064, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zswim6 was found to be indispensable to normal brain function and may contribute to neurodevelopmental disorders.
Title: Loss of the neurodevelopmental gene Zswim6 alters striatal morphology and motor regulation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237104

NoName (e-PCR)
- UniSTS:237107

RH130599 (e-PCR)
- UniSTS:213883

ZSWIM6__4731 (e-PCR)
- UniSTS:462976

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in striatal medium spiny neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul2-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in stereocilium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger SWIM domain-containing protein 6

Names: zinc finger, SWIM domain containing 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.