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    Tep2 Thioester-containing protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34044, updated on 26-Apr-2024

    Summary

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    Official Symbol
    Tep2provided by FlyBase
    Official Full Name
    Thioester-containing protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0041182
    Locus tag
    Dmel_CG7052
    See related
    AllianceGenome:FB:FBgn0041182
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    145970_at; 145971_at; CG18589; CG7052; Dmel\CG7052; dTEPII; T13; Tep 2; Tep II; TEP II; tep2; TEP2; TEP2mel; tepII; TepII
    Summary
    Predicted to enable endopeptidase inhibitor activity. Involved in defense response to Gram-negative bacterium and innate immune response. Located in extracellular space. Is expressed in several structures, including embryonic/larval corpus allatum; embryonic/larval hemocyte; procrystal cell; spermatozoon; and yolk nucleus. Human ortholog(s) of this gene implicated in several diseases, including complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; sickle cell anemia; and silicosis. Orthologous to several human genes including CD109 (CD109 molecule). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    28C1-28C1; 2-28 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7693727..7701601, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7693727..7701601, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Myosin 28B1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44990 Neighboring gene Thioester-containing protein 3 Neighboring gene transfer RNA:Tyrosine-GTA 1-9 Neighboring gene Neurotransmitter transporter-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Thioester-Containing Proteins 2 and 4 Affect the Metabolic Activity and Inflammation Response in Drosophila. Shokal U, et al. Infect Immun, 2018 May. PMID 29463615, Free PMC Article
    2. The distinct function of Tep2 and Tep6 in the immune defense of Drosophila melanogaster against the pathogen Photorhabdus. Shokal U, et al. Virulence, 2017 Nov 17. PMID 28498729, Free PMC Article
    3. Quorum-sensing regulator RhlR but not its autoinducer RhlI enables Pseudomonas to evade opsonization. Haller S, et al. EMBO Rep, 2018 May. PMID 29523648, Free PMC Article
    4. Evolution and Function of Thioester-Containing Proteins and the Complement System in the Innate Immune Response. Shokal U, et al. Front Immunol, 2017. PMID 28706521, Free PMC Article
    5. Thioester-containing Proteins in the Drosophila melanogaster Immune Response against the Pathogen Photorhabdus. Eleftherianos I, et al. Insects, 2020 Jan 28. PMID 32013030, Free PMC Article

    See all (108) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inactivation of Tep2 or Tep6 affects phagocytosis and melanization in flies infected with Photorhabdus.
      Title: The distinct function of Tep2 and Tep6 in the immune defense of Drosophila melanogaster against the pathogen Photorhabdus.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Thioester-containing protein 2
    Names
    CG7052-PA
    CG7052-PB
    CG7052-PD
    CG7052-PF
    CG7052-PG
    TEP
    Tep2-PA
    Tep2-PB
    Tep2-PD
    Tep2-PF
    Tep2-PG
    thioester containing protein II
    thiolester containing protein II

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7693727..7701601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164762.2 → NP_723299.2  Thioester-containing protein 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723299.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0ZWQ3, Q9VLZ0
      Conserved Domains (6) summary
      cd02897
      Location:898 → 1187
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:681 → 771
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:115 → 209
      A2M_N; MG2 domain
      pfam07677
      Location:1297 → 1387
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:950 → 1188
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:445 → 576
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    2. NM_164763.2 → NP_723300.2  Thioester-containing protein 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723300.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0ZWQ4, Q8IPH5
      Conserved Domains (6) summary
      cd02897
      Location:889 → 1178
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:670 → 762
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:115 → 209
      A2M_N; MG2 domain
      pfam07677
      Location:1288 → 1378
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:941 → 1179
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:445 → 576
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    3. NM_078782.3 → NP_523506.1  Thioester-containing protein 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523506.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0ZWQ0, A0ZWQ1, Q9NFV7, Q9VLY8
      Related
      FBpp0079133
      Conserved Domains (6) summary
      cd02897
      Location:909 → 1198
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:694 → 782
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:115 → 209
      A2M_N; MG2 domain
      pfam07677
      Location:1308 → 1398
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:961 → 1199
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:445 → 576
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    4. NM_164761.2 → NP_723298.1  Thioester-containing protein 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723298.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0ZWQ2, Q9VLY9
      Related
      FBpp0079134
      Conserved Domains (6) summary
      cd02897
      Location:888 → 1177
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:671 → 761
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:115 → 209
      A2M_N; MG2 domain
      pfam07677
      Location:1287 → 1377
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:940 → 1178
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:445 → 576
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    5. NM_164764.2 → NP_723301.1  Thioester-containing protein 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723301.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0ZWQ5, Q8IPH4
      Related
      FBpp0079136
      Conserved Domains (6) summary
      cd02897
      Location:897 → 1186
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:679 → 770
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:115 → 209
      A2M_N; MG2 domain
      pfam07677
      Location:1296 → 1386
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:949 → 1187
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:445 → 576
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IPH4 Q8IPH4
    Q8IPH5 Q8IPH5
    Q8MT94 Q8MT94
    Q9NFV7 Q9NFV7
    Q9VLY9 Q9VLY9
    Q9VLZ0 Q9VLZ0

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