cindr CIN85 and CD2AP related [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cindrprovided by FlyBase
Official Full Name: CIN85 and CD2AP relatedprovided by FlyBase
Primary source: FLYBASE:FBgn0027598
Locus tag: Dmel_CG31012
See related: AllianceGenome:FB:FBgn0027598
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GH03163; CD2AP; CG11316; CG1408; CG31012; Cindir; Cindr; Dmel\CG31012
Summary: Enables GTPase activating protein binding activity; SH3 domain binding activity; and cell adhesion molecule binding activity. Involved in several processes, including adherens junction assembly; border follicle cell migration; and positive regulation of receptor-mediated endocytosis. Located in several cellular components, including cleavage furrow; fusome; and midbody. Is active in apical cortex. Is expressed in several structures, including adult cerebral ganglion; eye; gonad; imaginal disc; and photoreceptor cell. Used to study nephrotic syndrome and tauopathy. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 3; and immunodeficiency 61. Orthologous to several human genes including SH3KBP1 (SH3 domain containing kinase binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 100A6-100A6; 3-101 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (30808617..30827005)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (26634339..26652727)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a genetic modifier screen that identified E3 ligases that modified the rough-eye phenotype generated by expression of cindr RNA interference transgenes during Drosophila eye development.
Title: A screen for E3 ubiquitination ligases that genetically interact with the adaptor protein Cindr during Drosophila eye patterning.
Silencing Cindr in nephrocytes led to dramatic nephrocyte functional impairment and shortened life span, as well as collapse of nephrocyte lacunar channels and effacement of nephrocyte slit diaphragms. These phenotypes could be rescued by expression of a wild-type human CD2AP gene, but not a mutant allele derived from a patient with CD2AP-associated NS.
Title: A Drosophila model system to assess the function of human monogenic podocyte mutations that cause nephrotic syndrome.
correct Cindr-dJNK stoichiometry is essential to maintain epithelial integrity and disturbing this balance may contribute to the pathogenesis of disease states, including cancer
Title: The adaptor protein Cindr regulates JNK activity to maintain epithelial sheet integrity.
Cindr co-localizes with Anillin at mitotic and meiotic ring canals and is recruited to the contractile ring by Anillin during male germ cell meiotic cytokinesis.
Title: Spatiotemporal control of Cindr at ring canals during incomplete cytokinesis in the Drosophila male germline.
Cindr recapitulates both proposed functions of its mammalian orthologs Cd2ap and Cin85: targeting the IgCAMs Rst and Hbs for endocytosis and stabilizing these heterophilic IgCAM complexes.
Title: Interactions between Drosophila IgCAM adhesion receptors and cindr, the Cd2ap/Cin85 ortholog.
Cindr-mediated regulation of Arf6 is a widely used mechanism in emerging epithelia. Cindr forms a physical complex with Asap
Title: Role for a Cindr-Arf6 axis in patterning emerging epithelia.
Data suggest that Cindr and Anillin cooperate to promote intercellular bridge stability during incomplete cytokinesis in Drosophila melanogaster.
Title: Cindr interacts with anillin to control cytokinesis in Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 30818868-30820372 mobile_element_type = transposon:1360{}1463

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTPase activating protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables SH3 domain binding	IDA Inferred from Direct Assay more info	PubMed
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adherens junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intercellular bridge organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor-mediated endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
located_in fusome	IDA Inferred from Direct Assay more info	PubMed
located_in intercellular bridge	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CIN85 and CD2AP related

Names: CD2AP and CIN85 orthologue; CG31012-PA; CG31012-PB; CG31012-PC; CG31012-PD; CG31012-PE; CG31012-PF; CG31012-PG; CG31012-PH; CG31012-PI; CG31012-PJ; CIN85 and CD2AP orthologue; cindr; cindr-PA; cindr-PB; cindr-PC; cindr-PD; cindr-PE; cindr-PF; cindr-PG; cindr-PH; cindr-PI; cindr-PJ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

30808617..30827005

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001276200.1 → NP_001263129.1 CIN85 and CD2AP related, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263129.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KI34, Q7YU85

Conserved Domains (3) summary

cd11873
Location:6 → 60

SH3_CD2AP-like_1; First Src Homology 3 domain (SH3A) of CD2-associated protein and similar proteins

cd11874
Location:97 → 149

SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins

cd11875
Location:258 → 310

SH3_CD2AP-like_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein and similar proteins
NM_001276195.1 → NP_001263124.1 CIN85 and CD2AP related, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263124.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KI32, Q7YU85

Conserved Domains (3) summary

cd11874
Location:63 → 115

SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins

cd11875
Location:224 → 276

SH3_CD2AP-like_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein and similar proteins

cl17036
Location:1 → 26

SH3; Src Homology 3 domain superfamily
NM_170526.3 → NP_733405.2 CIN85 and CD2AP related, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733405.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7YU85, Q9VA36

Related

FBpp0085066

Conserved Domains (3) summary

cd11873
Location:6 → 60

SH3_CD2AP-like_1; First Src Homology 3 domain (SH3A) of CD2-associated protein and similar proteins

cd11874
Location:97 → 149

SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins

cd11875
Location:258 → 310

SH3_CD2AP-like_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein and similar proteins
NM_001276197.1 → NP_001263126.1 CIN85 and CD2AP related, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263126.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHG1

Conserved Domains (1) summary

cd11875
Location:11 → 63

SH3_CD2AP-like_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein and similar proteins
NM_001276196.1 → NP_001263125.1 CIN85 and CD2AP related, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263125.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHJ8

Conserved Domains (1) summary

cd11875
Location:11 → 63

SH3_CD2AP-like_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein and similar proteins
NM_170528.3 → NP_733407.2 CIN85 and CD2AP related, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733407.2

Status: REVIEWED

UniProtKB/TrEMBL

Q86PF3

Related

FBpp0085067

Conserved Domains (1) summary

cd11875
Location:11 → 63

SH3_CD2AP-like_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein and similar proteins
NM_170527.3 → NP_733406.1 CIN85 and CD2AP related, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733406.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VA35

Related

FBpp0085069
NM_143570.4 → NP_651827.1 CIN85 and CD2AP related, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651827.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9Y154

Related

FBpp0085068
NM_001276198.1 → NP_001263127.1 CIN85 and CD2AP related, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263127.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9Y154
NM_001276199.1 → NP_001263128.1 CIN85 and CD2AP related, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263128.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9Y154

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4KHG1		A0A0B4KHG1
A0A0B4KHJ8		A0A0B4KHJ8
A0A0B4KI32		A0A0B4KI32
A0A0B4KI34		A0A0B4KI34
Q7YU85		Q7YU85
Q86PF3		Q86PF3
Q9VA35		Q9VA35
Q9VA36		Q9VA36
Q9Y154		Q9Y154