Nap1l2 nucleosome assembly protein 1-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nap1l2provided by MGI
Official Full Name: nucleosome assembly protein 1-like 2provided by MGI
Primary source: MGI:MGI:106654
See related: Ensembl:ENSMUSG00000082229 AllianceGenome:MGI:106654
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bpx
Summary: Enables chromatin binding activity and histone binding activity. Acts upstream of or within positive regulation of histone acetylation; positive regulation of neuron differentiation; and regulation of stem cell division. Predicted to be active in chromatin and nucleus. Is expressed in nervous system. Orthologous to human NAP1L2 (nucleosome assembly protein 1 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: X D; X 45.97 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (102227782..102230259, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (103184176..103186653, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results identified several proteins interacting with NAP1L2, including the ubiquitously expressed members of the nucleosome assembly protein family, NAP1L1 and NAP1L4.
Title: Interaction between nucleosome assembly protein 1-like family members.
Data show that Nap1l2 associates with chromatin and interacts with histones H3 and H4, and loss of Nap1l2 results in decreased histone acetylation activity, leading to transcriptional changes in differentiating neurons.
Title: Nap1l2 promotes histone acetylation activity during neuronal differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

X92352 (e-PCR)
- UniSTS:163623

X92352 (e-PCR)
- UniSTS:125887

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleosome assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nucleosome assembly protein 1-like 2

Names: brain-specific protein, X-linked

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.