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    Fcgrt Fc fragment of IgG receptor and transporter [ Mus musculus (house mouse) ]

    Gene ID: 14132, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Fcgrtprovided by MGI
    Official Full Name
    Fc fragment of IgG receptor and transporterprovided by MGI
    Primary source
    MGI:MGI:103017
    See related
    Ensembl:ENSMUSG00000003420 AllianceGenome:MGI:103017
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FcRn
    Summary
    Predicted to enable IgG binding activity and beta-2-microglobulin binding activity. Predicted to be involved in immune response. Predicted to be located in endosome and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including genitourinary system; intestine; liver; sensory organ; and skeleton. Orthologous to human FCGRT (Fc fragment of IgG receptor and transporter). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in placenta adult (RPKM 121.9), mammary gland adult (RPKM 87.9) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 B3; 7 29.12 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44742417..44753246, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45092993..45103822, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52317657-52317840 Neighboring gene nitric oxide synthase interacting protein Neighboring gene reticulocalbin 3, EF-hand calcium binding domain Neighboring gene STARR-seq mESC enhancer starr_18830 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52376860-52377101 Neighboring gene predicted gene 45552 Neighboring gene small nucleolar RNA, C/D box 35B Neighboring gene microRNA 150 Neighboring gene ribosomal protein S11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Knockout of the neonatal Fc receptor alters immune complex trafficking and lysosomal function in cultured podocytes. Haddad G, et al. PLoS One, 2023. PMID 37071647, Free PMC Article
    2. A precisely humanized FCRN transgenic mouse for preclinical pharmacokinetics studies. Conner CM, et al. Biochem Pharmacol, 2023 Apr. PMID 36870576
    3. DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2. Parzych EM, et al. Nat Commun, 2022 Oct 6. PMID 36202799, Free PMC Article
    4. Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life. Grevys A, et al. iScience, 2022 Feb 18. PMID 35118359, Free PMC Article
    5. Dynamics of intracellular neonatal Fc receptor-ligand interactions in primary macrophages using biophysical fluorescence techniques. Pannek A, et al. Mol Biol Cell, 2022 Jan 1. PMID 34731029, Free PMC Article

    See all (127) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neonatal Fc Receptor Inhibition Enables Adeno-Associated Virus Gene Therapy Despite Pre-Existing Humoral Immunity.
      Title: Neonatal Fc Receptor Inhibition Enables Adeno-Associated Virus Gene Therapy Despite Pre-Existing Humoral Immunity.
    2. Knockout of the neonatal Fc receptor alters immune complex trafficking and lysosomal function in cultured podocytes.
      Title: Knockout of the neonatal Fc receptor alters immune complex trafficking and lysosomal function in cultured podocytes.
    3. Dynamics of intracellular neonatal Fc receptor-ligand interactions in primary macrophages using biophysical fluorescence techniques.
      Title: Dynamics of intracellular neonatal Fc receptor-ligand interactions in primary macrophages using biophysical fluorescence techniques.
    4. Podocyte-specific knockout of the neonatal Fc receptor (FcRn) results in differential protection depending on the model of glomerulonephritis.
      Title: Podocyte-specific knockout of the neonatal Fc receptor (FcRn) results in differential protection depending on the model of glomerulonephritis.
    5. FcRn mediates fast recycling of endocytosed albumin and IgG from early macropinosomes in primary macrophages.
      Title: FcRn mediates fast recycling of endocytosed albumin and IgG from early macropinosomes in primary macrophages.
    6. In podocytes, Fcgrt modulates the IL-6 mediated response to inflammatory stimuli and regulates podocytes actin structure.
      Title: Knockout of the neonatal Fc receptor in cultured podocytes alters IL-6 signaling and the actin cytoskeleton.
    7. The studies demonstrate a pivotal role for FcRn-mediated salvage in compensating for the high pinocytic and degradative activities of macrophages to maintain IgG homeostasis.
      Title: Neonatal Fc receptor expression in macrophages is indispensable for IgG homeostasis.
    8. Knockout of FcRn leads to IgG accumulation in podocytes but does not alter albumin trafficking.
      Title: Differential trafficking of albumin and IgG facilitated by the neonatal Fc receptor in podocytes in vitro and in vivo.
    9. These findings support the critical role of FcRn downregulation in the tumor microenvironment in anti-tumor immunity, via NK cell maturation and activation.
      Title: Lack of FcRn Impairs Natural Killer Cell Development and Functions in the Tumor Microenvironment.
    10. Low FcRN expression is associated with proteinuria.
      Title: Reduced proximal tubular expression of protein endocytic receptors in proteinuria is associated with urinary receptor shedding.
    Submit: New GeneRIF Correction See all GeneRIFs (41)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (9) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables IgG binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-2-microglobulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-2-microglobulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    IgG receptor FcRn large subunit p51
    Names
    Fc receptor, IgG, alpha chain transporter
    igG Fc fragment receptor transporter alpha chain
    neonatal Fc receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357117.1 → NP_001344046.1  IgG receptor FcRn large subunit p51 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC126256
      Consensus CDS
      CCDS90230.1
      UniProtKB/TrEMBL
      Q6PKB0
      Related
      ENSMUSP00000147496.2, ENSMUST00000210642.2
      Conserved Domains (2) summary
      cl08246
      Location:25 → 201
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cl11960
      Location:205 → 292
      Ig; Immunoglobulin domain

    2. NM_010189.3 → NP_034319.2  IgG receptor FcRn large subunit p51 isoform 1 precursor

      See identical proteins and their annotated locations for NP_034319.2

      Status: VALIDATED

      Source sequence(s)
      AK146933, AK152879, BY063885
      Consensus CDS
      CCDS52243.1
      UniProtKB/Swiss-Prot
      Q61559, Q9QUR0, Q9R2A5
      Related
      ENSMUSP00000003512.8, ENSMUST00000003512.9
      Conserved Domains (2) summary
      cl08246
      Location:25 → 197
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cl11960
      Location:201 → 288
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44742417..44753246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61559.1 GenPept UniProtKB/Swiss-Prot:Q61559

    Gene LinkOut

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