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    Ndst4 N-deacetylase and N-sulfotransferase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362035, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Ndst4provided by RGD
    Official Full Name
    N-deacetylase and N-sulfotransferase 4provided by RGD
    Primary source
    RGD:1306531
    See related
    Ensembl:ENSRNOG00000009577 AllianceGenome:RGD:1306531
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable [heparan sulfate]-glucosamine N-sulfotransferase activity and deacetylase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Orthologous to human NDST4 (N-deacetylase and N-sulfotransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 33.2), Uterus (RPKM 4.9) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q42
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (216461542..216794035)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (213787010..214119514)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (229170781..229496732)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene glycophorin C, pseudogene 1 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 6 Neighboring gene ribosomal protein L7, pseudogene 17 Neighboring gene zinc finger and BTB domain-containing protein 7B-like Neighboring gene UDP glycosyltransferase 8 Neighboring gene heat shock protein 90 alpha family class B member 1, pseudogene 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4. Aikawa J, et al. J Biol Chem, 2001 Feb 23. PMID 11087757
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetylglucosamine deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables [heparan sulfate]-glucosamine N-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [heparan sulfate]-glucosamine N-sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heparin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4
    Names
    N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
    N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
    N-deacetylase/N-sulfotransferase 4
    NP_001178778.1
    XP_038958644.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191849.3 → NP_001178778.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4

      See identical proteins and their annotated locations for NP_001178778.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D3ZD27
      Related
      ENSRNOP00000012773.4, ENSRNOT00000012773.6
      Conserved Domains (2) summary
      pfam00685
      Location:594 → 845
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:20 → 505
      HSNSD; heparan sulfate-N-deacetylase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      216461542..216794035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102716.2 → XP_038958644.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 isoform X1

      UniProtKB/TrEMBL
      D3ZD27
      Conserved Domains (2) summary
      pfam00685
      Location:594 → 845
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:20 → 505
      HSNSD; heparan sulfate-N-deacetylase
    Nucleotide Protein Strain
    Heading Accession and Version

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