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    RKI1 ribose-5-phosphate isomerase RKI1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854262, updated on 11-Apr-2024

    Summary

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    Gene symbol
    RKI1
    Gene description
    ribose-5-phosphate isomerase RKI1
    Primary source
    SGD:S000005621
    Locus tag
    YOR095C
    See related
    AllianceGenome:SGD:S000005621
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ribose-5-phosphate isomerase activity. Involved in pentose-phosphate shunt and pyridoxine biosynthetic process. Located in cytoplasm and nucleus. Orthologous to human RPIA (ribose 5-phosphate isomerase A). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (503552..504328, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Cmr2p Neighboring gene Arf family GTPase ARF3 Neighboring gene ribosomal 40S subunit protein S7A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the S. cerevisiae D-ribose-5-phosphate isomerase: comparison with the archaeal and bacterial enzymes. Graille M, et al. Biochimie, 2005 Aug. PMID 16054529
    2. Pyridoxine biosynthesis in yeast: participation of ribose 5-phosphate ketol-isomerase. Kondo H, et al. Biochem J, 2004 Apr 1. PMID 14690456, Free PMC Article
    3. Multilevel engineering of the upstream module of aromatic amino acid biosynthesis in Saccharomyces cerevisiae for high production of polymer and drug precursors. Suástegui M, et al. Metab Eng, 2017 Jul. PMID 28625755
    4. Cloning and characterization of the first two genes of the non-oxidative part of the Saccharomyces cerevisiae pentose-phosphate pathway. Miosga T, et al. Curr Genet, 1996 Nov. PMID 8929392
    5. A screening for essential cell growth-related genes involved in arsenite toxicity in Saccharomyces cerevisiae. Takahashi T, et al. J Toxicol Sci, 2011. PMID 22129753

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribose-5-phosphate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribose-5-phosphate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribose-5-phosphate isomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in D-ribose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pentose-phosphate shunt IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pentose-phosphate shunt, non-oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pentose-phosphate shunt, non-oxidative branch IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyridoxine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    ribose-5-phosphate isomerase RKI1
    NP_014738.1
    • Ribose-5-phosphate ketol-isomerase; catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      503552..504328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183514.1 → NP_014738.1  TPA: ribose-5-phosphate isomerase RKI1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014738.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZNU5, D6W2F6, Q12189
      UniProtKB/TrEMBL
      A0A6A5Q2K3, B3LJE1, C7GMN9, C8ZI56, G2WMX2, N1NWX9
      Conserved Domains (1) summary
      TIGR00021
      Location:22 → 253
      rpiA; ribose 5-phosphate isomerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12189.1

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