Id1 inhibitor of DNA binding 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Id1provided by RGD
Official Full Name: inhibitor of DNA binding 1provided by RGD
Primary source: RGD:2858
See related: Ensembl:ENSRNOG00000021750 AllianceGenome:RGD:2858
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Idb1; ID125A
Summary: Enables several functions, including identical protein binding activity; proteasome binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to organonitrogen compound; and nervous system development. Located in centrosome and nucleus. Used to study pulmonary hypertension. Biomarker of cholestasis. Orthologous to human ID1 (inhibitor of DNA binding 1, HLH protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 290.4), Heart (RPKM 137.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (161671525..161672691)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (141210666..141212420)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (148214623..148216715)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results revealed the critical roles of Id1 and SHH mediating Abeta-dependent cell cycle reentry and subsequently caspase-dependent apoptosis in the fully differentiated post-mitotic neurons.
Title: Id1 and Sonic Hedgehog Mediate Cell Cycle Reentry and Apoptosis Induced by Amyloid Beta-Peptide in Post-mitotic Cortical Neurons.
Via RNAi, it was found that ID1 induction was inhibited with silencing of HIF-1alpha. Moreover, the suppression of ID1 mRNA expression could lead to decreased expression and transcription of HIF-1alpha during hypoxia and reoxygenation. In addition, it was demonstrated that both ID1 and HIF-1alpha can regulate the transcription of twist
Title: Inhibitor of DNA Binding 1 Is Induced during Kidney Ischemia-Reperfusion and Is Critical for the Induction of Hypoxia-Inducible Factor-1α.
These results thus established a signaling cascade of "Abeta --> Id1 --> HIF-1 --> SHH" in primary rat cortical cultures; furthermore, SHH may in part contribute to amyloid beta neurotoxicity.
Title: Inhibitor of Differentiation-1 and Hypoxia-Inducible Factor-1 Mediate Sonic Hedgehog Induction by Amyloid Beta-Peptide in Rat Cortical Neurons.
Smad1 as a novel binding protein of KSHV latency-associated nuclear antigen (LANA). LANA interacted with and sustained BMP-activated p-Smad1 in the nucleus and enhanced its loading on the Id promoters.
Title: Oncogenic herpesvirus KSHV Hijacks BMP-Smad1-Id signaling to promote tumorigenesis.
These data suggest that BMP4 may regulate survival through the Id1/EGFR pathway during development of the rat inner ear.
Title: Bone morphogenetic protein 4, inhibitor of differentiation 1, and epidermal growth factor receptor regulate the survival of cochlear sensory epithelial cells.
Results suggest that the Id1/PI3K/Akt/NFkappaB/survivin signalling pathway plays a critical role in endothelial progenitor cell proliferation.
Title: An essential role for the Id1/PI3K/Akt/NFkB/survivin signalling pathway in promoting the proliferation of endothelial progenitor cells in vitro.
Recombinant human bone morphogenetic protein 2 enhanced mesenchymal stem cell Id1 expression, required for vascular differentiation and spatial organisation, under normoxic conditions.
Title: Regeneration of three layers vascular wall by using BMP2-treated MSC involving HIF-1α and Id1 expressions through JAK/STAT pathways.
Prostacyclin analogues inhibited smooth muscle cell proliferation and prevented progression of pulmonary hypertension while enhancing Smad1/5 phosphorylation and Id1 gene expression.
Title: Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo.
Expression of all 4 members of the Id family of transcription factors is differentially regulated in response to orchidectomy along the epididymis.
Title: Expression, localization, and regulation of inhibitor of DNA binding (Id) proteins in the rat epididymis.
Treatment of PC12 cells with recombinant Tat enhances the NGF-induced Id1 expression, further pointing to Id1 as a target for Tat.
Title: HIV-Tat promotes cellular proliferation and inhibits NGF-induced differentiation through mechanisms involving Id1 regulation.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC33181P1 (e-PCR)
- UniSTS:273154

PMC156147P2 (e-PCR)
- UniSTS:271379

PMC133998P5 (e-PCR)
- UniSTS:270710

PMC145454P3 (e-PCR)
- UniSTS:271002

PMC305683P1 (e-PCR)
- UniSTS:272557

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables proteasome binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription regulator inhibitor activity	IEA Inferred from Electronic Annotation more info
enables transcription regulator inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-abiotic substrate adhesion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to dopamine	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to epidermal growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to nerve growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to peptide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in circadian regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within collagen metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endothelial cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung vasculature development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of actin filament bundle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein destabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to antibiotic	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA-binding protein inhibitor ID-1

Names: Inhibitor of DNA binding 1 helix-loop-helix protein (splice varaiation); Inhibitor of DNA binding 1, helix-loop-helix protein (splice variation); inhibitor of DNA binding 1, HLH protein; inhibitor of DNA binding 1, dominant negative helix-loop-helix protein; inhibitor of differentiation 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012797.2 → NP_036929.2 DNA-binding protein inhibitor ID-1

See identical proteins and their annotated locations for NP_036929.2

Status: VALIDATED

Source sequence(s)

AI073271, M86708

UniProtKB/Swiss-Prot

P41135

UniProtKB/TrEMBL

A0JPJ2, A6KHQ6

Conserved Domains (1) summary

cd19691
Location:55 → 106

bHLH_dnHLH_ID1; basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID1 and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

161671525..161672691

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006235267.5 → XP_006235329.1 DNA-binding protein inhibitor ID-1 isoform X1

UniProtKB/Swiss-Prot

P41135

UniProtKB/TrEMBL

A0A8L2QPI3, A6KHQ6

Related

ENSRNOP00000052261.3

Conserved Domains (1) summary

cd19691
Location:55 → 106

bHLH_dnHLH_ID1; basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID1 and similar proteins