Lamb2 laminin subunit beta 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lamb2provided by RGD
Official Full Name: laminin subunit beta 2provided by RGD
Primary source: RGD:2988
See related: Ensembl:ENSRNOG00000047768 AllianceGenome:RGD:2988
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SLAM
Summary: Predicted to enable integrin binding activity. Predicted to be an extracellular matrix structural constituent. Predicted to be involved in several processes, including basement membrane assembly; cell migration; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within several processes, including metanephric glomerulus development; neurogenesis; and visual perception. Predicted to be located in basement membrane and neuromuscular junction. Predicted to be part of laminin-3 complex. Predicted to be active in synaptic cleft. Used to study proteinuria. Human ortholog(s) of this gene implicated in Pierson syndrome and nephrotic syndrome type 5. Orthologous to human LAMB2 (laminin subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 741.8), Uterus (RPKM 372.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (118056899..118069090)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (109178367..109190552)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (117268335..117280517)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crystallographic analysis of the LAMB2 short arm reveals how the LF domain is inserted into a regular array of LE domains.
Title: Crystallographic analysis of the laminin β2 short arm reveals how the LF domain is inserted into a regular array of LE domains.
Together, these studies provide evidence for regulation of Lamb2 translation by IMP2, an RNA binding protein that targets Lamb2 mRNA to the actin cytoskeleton.
Title: RNA-binding protein IGF2BP2/IMP2 is required for laminin-β2 mRNA translation and is modulated by glucose concentration.
R246Q mutation causes nephrotic syndrome by impairing secretion of laminin-521 from podocytes into the glomerular basement membrane (GBM).
Title: A missense LAMB2 mutation causes congenital nephrotic syndrome by impairing laminin secretion.
Chronic exposure to high glucose leads to impaired mesangial cell migration in response to IGFBP-5 as a result of loss of laminin beta2 protein.
Title: Reductions in laminin beta2 mRNA translation are responsible for impaired IGFBP-5-mediated mesangial cell migration in the presence of high glucose.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:580683 (e-PCR)
- UniSTS:157844

GDB:580686 (e-PCR)
- UniSTS:157845

GDB:580690 (e-PCR)
- UniSTS:157846

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of synapse-associated extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of synapse-associated extracellular matrix	IEA Inferred from Electronic Annotation more info
enables structural constituent of synapse-associated extracellular matrix	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Schwann cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Schwann cell development	ISO Inferred from Sequence Orthology more info
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in astrocyte development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within astrocyte development	ISO Inferred from Sequence Orthology more info
involved_in axon extension involved in regeneration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon extension involved in regeneration	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
involved_in basement membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in metanephric glomerular basement membrane development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within metanephric glomerular basement membrane development	ISO Inferred from Sequence Orthology more info
involved_in metanephric podocyte development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within metanephric podocyte development	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular junction development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromuscular junction development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in retina development in camera-type eye	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synapse organization	ISO Inferred from Sequence Orthology more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basement membrane	ISO Inferred from Sequence Orthology more info
part_of laminin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of laminin complex	ISO Inferred from Sequence Orthology more info
part_of laminin-3 complex	IEA Inferred from Electronic Annotation more info
part_of laminin-3 complex	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
is_active_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic cleft	IEA Inferred from Electronic Annotation more info
is_active_in synaptic cleft	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: laminin subunit beta-2

Names: S-LAM beta; S-laminin subunit beta; laminin chain B3; laminin chain beta 2; laminin, beta 2; laminin-11 subunit beta; laminin-14 subunit beta; laminin-15 subunit beta; laminin-3 subunit beta; laminin-4 subunit beta; laminin-7 subunit beta; laminin-9 subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012974.1 → NP_037106.1 laminin subunit beta-2 precursor

See identical proteins and their annotated locations for NP_037106.1

Status: VALIDATED

Source sequence(s)

X16563

UniProtKB/Swiss-Prot

P15800

UniProtKB/TrEMBL

Q5M7W9

Related

ENSRNOP00000065052.1, ENSRNOT00000072098.3

Conserved Domains (9) summary

TIGR02473
Location:1477 → 1617

flagell_FliJ; flagellar export protein FliJ

smart00180
Location:786 → 831

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:524 → 565

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00053
Location:1146 → 1185

Laminin_EGF; Laminin EGF domain

pfam00055
Location:60 → 284

Laminin_N; Laminin N-terminal (Domain VI)

pfam12795
Location:1582 → 1776

MscS_porin; Mechanosensitive ion channel porin domain

pfam14346
Location:1446 → 1516

DUF4398; Domain of unknown function (DUF4398)

cl15454
Location:1485 → 1673

HrpJ; HrpJ-like domain

cl21478
Location:1684 → 1795

ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

118056899..118069090

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006243709.4 → XP_006243771.1 laminin subunit beta-2 isoform X1

See identical proteins and their annotated locations for XP_006243771.1

UniProtKB/TrEMBL

A6I359, M0R6K0, Q5M7W9

Conserved Domains (9) summary

TIGR02473
Location:1477 → 1617

flagell_FliJ; flagellar export protein FliJ

smart00180
Location:786 → 831

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:524 → 565

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00053
Location:1146 → 1185

Laminin_EGF; Laminin EGF domain

pfam00055
Location:60 → 284

Laminin_N; Laminin N-terminal (Domain VI)

pfam12795
Location:1582 → 1776

MscS_porin; Mechanosensitive ion channel porin domain

pfam14346
Location:1446 → 1516

DUF4398; Domain of unknown function (DUF4398)

cl15454
Location:1485 → 1673

HrpJ; HrpJ-like domain

cl21478
Location:1684 → 1795

ATP-synt_B; ATP synthase B/B' CF(0)
XM_039080881.1 → XP_038936809.1 laminin subunit beta-2 isoform X2

UniProtKB/TrEMBL

Q5M7W9

Conserved Domains (6) summary

smart00180
Location:786 → 831

EGF_Lam; Laminin-type epidermal growth factor-like domai

COG1196
Location:1205 → 1798

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00055
Location:524 → 565

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00053
Location:1146 → 1193

Laminin_EGF; Laminin EGF domain

pfam00055
Location:51 → 284

Laminin_N; Laminin N-terminal (Domain VI)

cd22299
Location:1729 → 1800

cc_LAMB2_C; C-terminal coiled-coil domain found in laminin subunit beta-2 (LAMB2)
XM_039080882.2 → XP_038936810.1 laminin subunit beta-2 isoform X3

UniProtKB/TrEMBL

Q5M7W9

Conserved Domains (6) summary

smart00180
Location:652 → 697

EGF_Lam; Laminin-type epidermal growth factor-like domai

COG1196
Location:1071 → 1665

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00055
Location:390 → 431

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00053
Location:1012 → 1059

Laminin_EGF; Laminin EGF domain

pfam00055
Location:2 → 150

Laminin_N; Laminin N-terminal (Domain VI)

cd22299
Location:1596 → 1667

cc_LAMB2_C; C-terminal coiled-coil domain found in laminin subunit beta-2 (LAMB2)