Otc ornithine transcarbamylase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Otcprovided by RGD
Official Full Name: ornithine transcarbamylaseprovided by RGD
Primary source: RGD:3236
See related: Ensembl:ENSRNOG00000003370 AllianceGenome:RGD:3236
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including identical protein binding activity; ornithine carbamoyltransferase activity; and phosphate ion binding activity. Involved in several processes, including alpha-amino acid metabolic process; response to biotin; and urea cycle. Located in mitochondrial inner membrane. Used to study ornithine carbamoyltransferase deficiency. Biomarker of cholestasis; fatty liver disease; and obesity. Human ortholog(s) of this gene implicated in ornithine carbamoyltransferase deficiency. Orthologous to human OTC (ornithine transcarbamylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 2481.0) See more
Orthologs: human mouse all
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Genomic context

Location:: Xq12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (15126358..15202473, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (12453834..12529954, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (13524804..13601074, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circadian oscillation expression of ornithine carbamoyltransferase and its significance in sleep disturbance.
Title: Circadian oscillation expression of ornithine carbamoyltransferase and its significance in sleep disturbance.
Mitochondrion-derived markers, especially OCT, appeared superior to cytosol-derived markers in the detection of alcohol-induced liver injury.
Title: Ornithine carbamyltransferase is a sensitive marker for alcohol-induced liver injury.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amino acid binding	IEA Inferred from Electronic Annotation more info
enables amino acid binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ornithine carbamoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ornithine carbamoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ornithine carbamoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables ornithine carbamoyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ornithine carbamoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables phosphate ion binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ammonium homeostasis	ISO Inferred from Sequence Orthology more info
involved_in arginine biosynthetic process via ornithine	IBA Inferred from Biological aspect of Ancestor more info
involved_in citrulline biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in citrulline biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in citrulline biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in midgut development	IEP Inferred from Expression Pattern more info	PubMed
involved_in monoatomic anion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in ornithine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ornithine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to biotin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in urea cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in urea cycle	IEA Inferred from Electronic Annotation more info
involved_in urea cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ornithine transcarbamylase, mitochondrial

Names: OTCase; ornithine carbamoyltransferase, mitochondrial

NP_037210.1

EC 2.1.3.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013078.2 → NP_037210.1 ornithine transcarbamylase, mitochondrial precursor

See identical proteins and their annotated locations for NP_037210.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

P00481, Q63407

UniProtKB/TrEMBL

A0A8I5ZYC6, A6K017

Related

ENSRNOP00000004686.1, ENSRNOT00000004686.4

Conserved Domains (3) summary

PRK00779
Location:36 → 342

PRK00779; ornithine carbamoyltransferase; Provisional

pfam00185
Location:188 → 341

OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain

pfam02729
Location:41 → 181

OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain