Rab6a RAB6A, member RAS oncogene family [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rab6aprovided by RGD
Official Full Name: RAB6A, member RAS oncogene familyprovided by RGD
Primary source: RGD:619737
See related: Ensembl:ENSRNOG00000018176 AllianceGenome:RGD:619737
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rab6; Rab6b; RCO4-3
Summary: Enables several functions, including ATPase activator activity; ATPase binding activity; and GTP binding activity. Predicted to be involved in several processes, including Golgi vesicle transport; intracellular protein transport; and protein localization to Golgi apparatus. Predicted to act upstream of or within peptidyl-cysteine methylation. Located in membrane. Is active in presynapse. Colocalizes with Golgi apparatus. Orthologous to human RAB6A (RAB6A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 1044.9), Muscle (RPKM 339.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (164370033..164422324)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (154957870..155008922)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (165624973..165664201)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers.
Title: Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers.
Rab1 and Rab6 GTPases may play a role in modulating the function of retina by mediating the transport of nascent proteins along the early secretary pathway, particularly in the process of the light adaptation.
Title: Cell type-specific and light-dependent expression of Rab1 and Rab6 GTPases in mammalian retinas.
Rab6A and Rab6A' regulate microtubule-dependent recycling at the trans-Golgi network [Rab6A/Rab6A']
Title: Regulation of microtubule-dependent recycling at the trans-Golgi network by Rab6A and Rab6A'.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137608 (e-PCR)
- UniSTS:219695

A007D11 (e-PCR)
- UniSTS:362

RH143585 (e-PCR)
- UniSTS:232831

AW531825 (e-PCR)
- UniSTS:260543

RH127608 (e-PCR)
- UniSTS:210918

RH71435 (e-PCR)
- UniSTS:25838

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables myosin V binding	IEA Inferred from Electronic Annotation more info
enables myosin V binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Rab protein signal transduction	IC Inferred by Curator more info	PubMed
involved_in antigen processing and presentation	IEA Inferred from Electronic Annotation more info
involved_in antigen processing and presentation	ISO Inferred from Sequence Orthology more info
involved_in early endosome to Golgi transport	IEA Inferred from Electronic Annotation more info
involved_in early endosome to Golgi transport	ISO Inferred from Sequence Orthology more info
involved_in intra-Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to Golgi apparatus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to Golgi membrane	IEA Inferred from Electronic Annotation more info
involved_in protein localization to Golgi membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in acrosomal membrane	IEA Inferred from Electronic Annotation more info
located_in acrosomal membrane	ISO Inferred from Sequence Orthology more info
located_in acrosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome to plasma membrane transport vesicle	IEA Inferred from Electronic Annotation more info
located_in endosome to plasma membrane transport vesicle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	EXP Inferred from Experiment more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Rab-6A

Names: RAB6, member RAS oncogene family; RAB6B, member RAS oncogene family; rab-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001414455.1 → NP_001401384.1 ras-related protein Rab-6A isoform 1

Status: VALIDATED

Description

Transcript Variant: Variants 1 and 2 include either one of two duplicated, alternatively spliced coding exons and are the same length. The resulting proteins (isoforms 1 and 2, respectively) are the same length but differ at three amino acid positions. This variant (1) encodes isoform 1.

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q9WVB1

UniProtKB/TrEMBL

A6I6Q3

Related

ENSRNOP00000025104.5, ENSRNOT00000025104.7
NM_053366.2 → NP_445818.1 ras-related protein Rab-6A isoform 2

See identical proteins and their annotated locations for NP_445818.1

Status: VALIDATED

Description

Transcript Variant: Variants 1 and 2 include either one of two duplicated, alternatively spliced coding exons and are the same length. The resulting proteins (isoforms 1 and 2, respectively) are the same length but differ at three amino acid positions. This variant (2) encodes isoform 2.

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I5ZJD7, A6I6Q2

Related

ENSRNOP00000077083.1, ENSRNOT00000095981.1

Conserved Domains (1) summary

cd01861
Location:14 → 174

Rab6; Rab GTPase family 6 (Rab6)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

164370033..164422324

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092745.2 → XP_038948673.1 ras-related protein Rab-6A isoform X1

Conserved Domains (1) summary

cd01861
Location:14 → 173

Rab6; Rab GTPase family 6 (Rab6)