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    Mlip muscular LMNA-interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681849, updated on 3-Apr-2024

    Summary

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    Symbol
    Mlipprovided by RGD
    Full Name
    muscular LMNA-interacting proteinprovided by RGD
    Primary source
    RGD:1590513
    See related
    Ensembl:ENSRNOG00000005934 AllianceGenome:RGD:1590513
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CIP
    Summary
    Predicted to enable lamin binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to be located in PML body; nuclear envelope; and sarcolemma. Orthologous to human MLIP (muscular LMNA interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 263.0), Muscle (RPKM 150.0) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    8q24
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (86815491..87085117, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (77935087..78204725, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (84409957..84634637, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480074 Neighboring gene U2 spliceosomal RNA Neighboring gene tubulointerstitial nephritis antigen Neighboring gene leucine rich repeat containing 1 Neighboring gene uncharacterized LOC120094211

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation. Cattin ME, et al. J Biol Chem, 2015 Oct 30. PMID 26359501, Free PMC Article
    2. Identification of a novel muscle A-type lamin-interacting protein (MLIP). Ahmady E, et al. J Biol Chem, 2011 Jun 3. PMID 21498514, Free PMC Article
    3. Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. Huang ZP, et al. J Clin Invest, 2015 Nov 2. PMID 26436652, Free PMC Article
    4. CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. Huang ZP, et al. Circ Res, 2012 Mar 16. PMID 22343712, Free PMC Article
    5. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lamin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cardiac muscle hypertrophy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cardiac muscle hypertrophy in response to stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    muscular LMNA-interacting protein
    Names
    cardiac Isl1-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399373.1 → NP_001386302.1  muscular LMNA-interacting protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A096MJS3
      Related
      ENSRNOP00000068241.1, ENSRNOT00000076213.3
      Conserved Domains (2) summary
      PHA03307
      Location:361 → 614
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15274
      Location:566 → 774
      MLIP; Muscular LMNA-interacting protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      86815491..87085117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082515.2 → XP_038938443.1  muscular LMNA-interacting protein isoform X1

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Conserved Domains (3) summary
      PHA03307
      Location:505 → 758
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK10118
      Location:417 → 584
      PRK10118; flagellar hook length control protein FliK
      pfam15274
      Location:710 → 946
      MLIP; Muscular LMNA-interacting protein

    2. XM_039082514.2 → XP_038938442.1  muscular LMNA-interacting protein isoform X1

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Related
      ENSRNOP00000076453.1
      Conserved Domains (3) summary
      PHA03307
      Location:505 → 758
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK10118
      Location:417 → 584
      PRK10118; flagellar hook length control protein FliK
      pfam15274
      Location:710 → 946
      MLIP; Muscular LMNA-interacting protein

    3. XM_063266137.1 → XP_063122207.1  muscular LMNA-interacting protein isoform X18

    4. XM_063266135.1 → XP_063122205.1  muscular LMNA-interacting protein isoform X15

    5. XM_063266136.1 → XP_063122206.1  muscular LMNA-interacting protein isoform X17

      UniProtKB/TrEMBL
      A0A8I5ZRC1

    6. XM_063266134.1 → XP_063122204.1  muscular LMNA-interacting protein isoform X13

    7. XM_063266132.1 → XP_063122202.1  muscular LMNA-interacting protein isoform X6

    8. XM_039082517.2 → XP_038938445.1  muscular LMNA-interacting protein isoform X3

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Conserved Domains (2) summary
      PHA03307
      Location:386 → 639
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15274
      Location:591 → 827
      MLIP; Muscular LMNA-interacting protein

    9. XM_039082516.2 → XP_038938444.1  muscular LMNA-interacting protein isoform X2

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Related
      ENSRNOP00000097271.1
      Conserved Domains (2) summary
      PHA03307
      Location:438 → 691
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15274
      Location:643 → 879
      MLIP; Muscular LMNA-interacting protein

    10. XM_039082520.2 → XP_038938448.1  muscular LMNA-interacting protein isoform X6

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Conserved Domains (2) summary
      PHA03307
      Location:365 → 618
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15274
      Location:570 → 806
      MLIP; Muscular LMNA-interacting protein

    11. XM_039082521.2 → XP_038938449.1  muscular LMNA-interacting protein isoform X5

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Conserved Domains (2) summary
      PHA03307
      Location:413 → 666
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15274
      Location:618 → 806
      MLIP; Muscular LMNA-interacting protein

    12. XM_039082519.2 → XP_038938447.1  muscular LMNA-interacting protein isoform X6

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Conserved Domains (2) summary
      PHA03307
      Location:365 → 618
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15274
      Location:570 → 806
      MLIP; Muscular LMNA-interacting protein

    13. XM_039082522.2 → XP_038938450.1  muscular LMNA-interacting protein isoform X8

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Conserved Domains (2) summary
      PHA03307
      Location:361 → 614
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15274
      Location:566 → 802
      MLIP; Muscular LMNA-interacting protein

    14. XM_039082524.2 → XP_038938452.1  muscular LMNA-interacting protein isoform X9

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Conserved Domains (2) summary
      PHA03307
      Location:413 → 666
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15274
      Location:618 → 782
      MLIP; Muscular LMNA-interacting protein

    15. XM_039082525.2 → XP_038938453.1  muscular LMNA-interacting protein isoform X10

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Conserved Domains (3) summary
      PHA03307
      Location:413 → 666
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK10118
      Location:325 → 492
      PRK10118; flagellar hook length control protein FliK
      pfam15274
      Location:687 → 760
      MLIP; Muscular LMNA-interacting protein

    16. XM_039082518.2 → XP_038938446.1  muscular LMNA-interacting protein isoform X4

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Conserved Domains (2) summary
      PHA03307
      Location:413 → 666
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15274
      Location:618 → 826
      MLIP; Muscular LMNA-interacting protein

    17. XM_063266133.1 → XP_063122203.1  muscular LMNA-interacting protein isoform X11

      UniProtKB/TrEMBL
      A0A096MJS3

    18. XM_039082528.2 → XP_038938456.1  muscular LMNA-interacting protein isoform X14

      Conserved Domains (1) summary
      pfam15274
      Location:113 → 295
      MLIP; Muscular LMNA-interacting protein

    19. XM_039082527.1 → XP_038938455.1  muscular LMNA-interacting protein isoform X12

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Conserved Domains (2) summary
      PHA03307
      Location:361 → 614
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15274
      Location:566 → 774
      MLIP; Muscular LMNA-interacting protein

    20. XM_039082529.1 → XP_038938457.1  muscular LMNA-interacting protein isoform X16

      Conserved Domains (1) summary
      pfam15274
      Location:113 → 271
      MLIP; Muscular LMNA-interacting protein

    21. XM_039082523.1 → XP_038938451.1  muscular LMNA-interacting protein isoform X7

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Related
      ENSRNOP00000088810.1, ENSRNOT00000101165.1
      Conserved Domains (2) summary
      PHA03307
      Location:413 → 666
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15274
      Location:618 → 802
      MLIP; Muscular LMNA-interacting protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A096MK47.2 GenPept UniProtKB/Swiss-Prot:A0A096MK47

    Gene LinkOut

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