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    Rasl11b RAS-like family 11 member B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305302, updated on 5-Mar-2024

    Summary

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    Symbol
    Rasl11bprovided by RGD
    Full Name
    RAS-like family 11 member Bprovided by RGD
    Primary source
    RGD:1303099
    See related
    Ensembl:ENSRNOG00000002097 AllianceGenome:RGD:1303099
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transforming growth factor beta receptor binding activity. Predicted to act upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway. Orthologous to human RASL11B (RAS like family 11 member B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 121.5), Heart (RPKM 81.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    14p11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (34369029..34373250, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (34014924..34019146, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (36550353..36554574, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ligand of numb-protein X 1 Neighboring gene factor interacting with PAPOLA and CPSF1 Neighboring gene sec1 family domain containing 2 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134481840 Neighboring gene uncharacterized LOC102554412

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer. Finlin BS, et al. J Biol Chem, 2001 Nov 9. PMID 11533059
    2. RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta. Piek E, et al. Biochem J, 2004 Oct 1. PMID 15239668, Free PMC Article
    3. RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors. Louro R, et al. Biochem Biophys Res Commun, 2004 Apr 9. PMID 15033445
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transforming growth factor beta receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transforming growth factor beta receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras-like protein family member 11B
    NP_001002830.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002830.2 → NP_001002830.1  ras-like protein family member 11B

      See identical proteins and their annotated locations for NP_001002830.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083755
      UniProtKB/Swiss-Prot
      Q6IMA7
      UniProtKB/TrEMBL
      A0A8I6GM65, A6JD21
      Related
      ENSRNOP00000002869.3, ENSRNOT00000002869.6
      Conserved Domains (1) summary
      cd04146
      Location:34 → 201
      RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      34369029..34373250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IMA7.1 GenPept UniProtKB/Swiss-Prot:Q6IMA7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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