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    Ganc glucosidase, alpha; neutral C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24382, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Gancprovided by RGD
    Official Full Name
    glucosidase, alpha; neutral Cprovided by RGD
    Primary source
    RGD:2660
    See related
    Ensembl:ENSRNOG00000024563 AllianceGenome:RGD:2660
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable alpha-1,4-glucosidase activity. Predicted to be involved in N-glycan processing. Orthologous to human GANC (glucosidase alpha, neutral C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 134.7), Thymus (RPKM 76.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    3q35
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (127807132..127858995)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (107353369..107406104)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (112173907..112226886)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group IVF Neighboring gene ribosomal protein S25, pseudogene 11 Neighboring gene VPS39 subunit of HOPS complex Neighboring gene transmembrane protein 87A Neighboring gene uncharacterized LOC108350445 Neighboring gene small nucleolar RNA SNORA15 Neighboring gene calpain 3 Neighboring gene zinc finger protein 106

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Chromosomal assignments of 23 biochemical loci of the rat by using rat x mouse somatic cell hybrids. Yasue M, et al. Cytogenet Cell Genet, 1991. PMID 1914521
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-1,4-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,4-glucosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neutral alpha-glucosidase C
    Names
    neutral C
    NP_001139312.1
    XP_038960171.1
    XP_063139146.1
    XP_063139147.1
    XP_063139148.1
    XP_063139149.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145840.1 → NP_001139312.1  neutral alpha-glucosidase C

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      D4A7G5
      Related
      ENSRNOP00000011369.5, ENSRNOT00000011369.6
      Conserved Domains (3) summary
      cd06603
      Location:352 → 819
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:212 → 352
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
      pfam01055
      Location:333 → 778
      Glyco_hydro_31; Glycosyl hydrolases family 31

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      127807132..127858995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283077.1 → XP_063139147.1  neutral alpha-glucosidase C isoform X2

    2. XM_063283078.1 → XP_063139148.1  neutral alpha-glucosidase C isoform X3

    3. XM_063283076.1 → XP_063139146.1  neutral alpha-glucosidase C isoform X1

    4. XM_039104243.2 → XP_038960171.1  neutral alpha-glucosidase C isoform X4

      Conserved Domains (2) summary
      cd06603
      Location:352 → 767
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:212 → 352
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)

    5. XM_063283079.1 → XP_063139149.1  neutral alpha-glucosidase C isoform X5

    RNA

    1. XR_005501772.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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