Ddah1 dimethylarginine dimethylaminohydrolase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ddah1provided by MGI
Official Full Name: dimethylarginine dimethylaminohydrolase 1provided by MGI
Primary source: MGI:MGI:1916469
See related: Ensembl:ENSMUSG00000028194 AllianceGenome:MGI:1916469
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2410006N07Rik; 2510015N06Rik
Summary: Enables dimethylargininase activity. Involved in positive regulation of nitric oxide biosynthetic process and regulation of systemic arterial blood pressure. Located in mitochondrion. Is expressed in several structures, including brain; cardiovascular system; future prosencephalon; retina; and spinal cord. Human ortholog(s) of this gene implicated in cardiovascular system disease and hypertension. Orthologous to human DDAH1 (dimethylarginine dimethylaminohydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in kidney adult (RPKM 50.5), liver adult (RPKM 34.0) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H2; 3 70.63 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (145464447..145600032)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (145758692..145894277)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis.
Title: DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis.
Knock-out of the critical nitric oxide synthase regulator DDAH1 in mice impacts amphetamine sensitivity and dopamine metabolism.
Title: Knock-out of the critical nitric oxide synthase regulator DDAH1 in mice impacts amphetamine sensitivity and dopamine metabolism.
Dimethylarginine dimethylaminohydrolase 1 protects PM2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress.
Title: Dimethylarginine dimethylaminohydrolase 1 protects PM(2.5) exposure-induced lung injury in mice by repressing inflammation and oxidative stress.
Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation.
Title: Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation.
Overexpression of dimethylarginine dimethylaminohydrolase 1 protects from angiotensin II-induced cardiac hypertrophy and vascular remodeling.
Title: Overexpression of dimethylarginine dimethylaminohydrolase 1 protects from angiotensin II-induced cardiac hypertrophy and vascular remodeling.
Dimethylarginine dimethylaminohydrolase-1 contributes to exercise-induced cardiac angiogenesis in mice.
Title: Dimethylarginine dimethylaminohydrolase-1 contributes to exercise-induced cardiac angiogenesis in mice.
Blueberry anthocyaninenriched extract ameliorates transverse aortic constrictioninduced myocardial dysfunction via the DDAH1/ADMA/NO signaling pathway in mice.
Title: Blueberry anthocyanin‑enriched extract ameliorates transverse aortic constriction‑induced myocardial dysfunction via the DDAH1/ADMA/NO signaling pathway in mice.
Fluid reabsorption in the proximal tubule is reduced by tubular ADMA or by blocking its metabolism by DDAH-1.
Title: Regulation of fluid reabsorption in rat or mouse proximal renal tubules by asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase 1.
DDAH1 in cardiomyocytes plays a vital role in attenuating left ventricular remodeling after acute myocardial infarction by regulating intracellular ROS levels and apoptosis sensitivity via a SOD2-dependent pathway.
Title: Cardiomyocyte dimethylarginine dimethylaminohydrolase1 attenuates left-ventricular remodeling after acute myocardial infarction: involvement in oxidative stress and apoptosis.
Cardiomyocyte DDAH1 activity is dispensable for cardiac function under basal conditions, but plays an important role in attenuating cardiac hypertrophy and ventricular remodeling under stress conditions, possibly through locally confined regulation of subcellular ADMA and NO signaling.
Title: Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW050362 (e-PCR)
- UniSTS:178950

AI987801 (e-PCR)
- UniSTS:165304

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables amino acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables amino acid binding	ISO Inferred from Sequence Orthology more info
enables dimethylargininase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dimethylargininase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables dimethylargininase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in arginine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in arginine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arginine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in citrulline metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in citrulline metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein nitrosylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

Names: DDAH-1; DDAHI; dimethylargininase-1

NP_081269.1

EC 3.5.3.18

XP_011238523.1

EC 3.5.3.18

XP_017175201.1

EC 3.5.3.18

XP_030108663.1

EC 3.5.3.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026993.3 → NP_081269.1 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

See identical proteins and their annotated locations for NP_081269.1

Status: VALIDATED

Source sequence(s)

AK010970, AK148907, AK149185

Consensus CDS

CCDS17896.1

UniProtKB/Swiss-Prot

Q3UF65, Q9CWS0

Related

ENSMUSP00000029845.9, ENSMUST00000029845.15

Conserved Domains (1) summary

cl19186
Location:11 → 276

Amidinotransf; Amidinotransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

145464447..145600032

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011240221.4 → XP_011238523.1 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform X2

See identical proteins and their annotated locations for XP_011238523.1

UniProtKB/TrEMBL

D3YU15, Q3UF01

Conserved Domains (1) summary

cl19186
Location:3 → 173

Amidinotransf; Amidinotransferase
XM_030252803.1 → XP_030108663.1 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform X2

UniProtKB/TrEMBL

D3YU15, Q3UF01

Related

ENSMUSP00000112747.2, ENSMUST00000120310.2

Conserved Domains (1) summary

cl19186
Location:3 → 173

Amidinotransf; Amidinotransferase
XM_017319712.2 → XP_017175201.1 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform X1

UniProtKB/TrEMBL

Q3UF01

Conserved Domains (1) summary

cl19186
Location:23 → 193

Amidinotransf; Amidinotransferase