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    Gsta2 glutathione S-transferase, alpha 2 (Yc2) [ Mus musculus (house mouse) ]

    Gene ID: 14858, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Gsta2provided by MGI
    Official Full Name
    glutathione S-transferase, alpha 2 (Yc2)provided by MGI
    Primary source
    MGI:MGI:95863
    See related
    Ensembl:ENSMUSG00000057933 AllianceGenome:MGI:95863
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gstc2; Gst2-2; Gstc-2
    Summary
    Predicted to enable several functions, including anion binding activity; dinitrosyl-iron complex binding activity; and glutathione peroxidase activity. Acts upstream of or within response to bacterium and response to stilbenoid. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and skeleton. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to several human genes including GSTA5 (glutathione S-transferase alpha 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 167.8), stomach adult (RPKM 16.8) and 1 other tissue See more
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    Genomic context

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    See Gsta2 in Genome Data Viewer
    Location:
    9 E1; 9 43.65 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (78238300..78254474, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (78331018..78347192, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene oocyte maturation, alpha Neighboring gene oocyte maturation, beta Neighboring gene CRISPRi-validated DppDn enhancer cluster Neighboring gene CRISPRi-validated DppUp enhancer cluster Neighboring gene developmental pluripotency associated 5A Neighboring gene oocyte expressed protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Protein depletion and refeeding change the proportion of mouse liver glutathione S-transferase subunits. García-Mata R, et al. Biochim Biophys Acta, 1997 Jul 24. PMID 9268051
    2. Cloning, expression, and biochemical characterization of a functionally novel alpha class glutathione S-transferase with exceptional activity in the glutathione conjugation of (+)-anti-7,8-dihydroxy-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene. Xia H, et al. Arch Biochem Biophys, 1998 May 15. PMID 9606968
    3. Complementary DNA cloning, messenger RNA expression, and induction of alpha-class glutathione S-transferases in mouse tissues. Buetler TM, et al. Cancer Res, 1992 Jan 15. PMID 1728405
    4. Tissue-specific induction of murine glutathione transferase mRNAs by butylated hydroxyanisole. Pearson WR, et al. J Biol Chem, 1988 Sep 15. PMID 3417659
    5. Genetic mapping and systematic screening of mouse endogenously imprinted loci detected with restriction landmark genome scanning method (RLGS). Shibata H, et al. Mamm Genome, 1994 Dec. PMID 7894162

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dinitrosyl-iron complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables steroid delta-isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to stilbenoid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase A2
    Names
    GST class-alpha member 2
    glutathione S-transferase GT41A
    NP_032208.2
    XP_006510877.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008182.3 → NP_032208.2  glutathione S-transferase A2

      See identical proteins and their annotated locations for NP_032208.2

      Status: VALIDATED

      Source sequence(s)
      AC138587
      Consensus CDS
      CCDS23359.1
      UniProtKB/Swiss-Prot
      P10648, Q6P8Q1
      UniProtKB/TrEMBL
      Q8K0V9
      Related
      ENSMUSP00000034902.6, ENSMUST00000034902.12
      Conserved Domains (2) summary
      cd03208
      Location:86 → 220
      GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
      cd03077
      Location:4 → 82
      GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      78238300..78254474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510814.2 → XP_006510877.1  glutathione S-transferase A2 isoform X1

      See identical proteins and their annotated locations for XP_006510877.1

      UniProtKB/Swiss-Prot
      P10648, Q6P8Q1
      UniProtKB/TrEMBL
      Q8K0V9
      Related
      ENSMUSP00000117101.2, ENSMUST00000129247.2
      Conserved Domains (2) summary
      cd03208
      Location:86 → 220
      GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
      cd03077
      Location:4 → 82
      GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10648.3 GenPept UniProtKB/Swiss-Prot:P10648

    Gene LinkOut

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