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    TRPC5 transient receptor potential cation channel subfamily C member 5 [ Bos taurus (cattle) ]

    Gene ID: 407103, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TRPC5provided by VGNC
    Official Full Name
    transient receptor potential cation channel subfamily C member 5provided by VGNC
    Primary source
    VGNC:VGNC:36385
    See related
    BGD:BT12543; Ensembl:ENSBTAG00000010065
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    trp
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (59966892..60322797, complement)

    Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene UDP-N-acetylglucosamine transferase subunit ALG13 homolog Neighboring gene putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 Neighboring gene TRPC5 opposite strand Neighboring gene retrotransposon Gag like 4 Neighboring gene uncharacterized LOC132344287 Neighboring gene LHFPL tetraspan subfamily member 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nitric oxide activates TRP channels by cysteine S-nitrosylation. Yoshida T, et al. Nat Chem Biol, 2006 Nov. PMID 16998480
    2. Nitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells. Wong CO, et al. Pflugers Arch, 2010 Jun. PMID 20390293, Free PMC Article
    3. TRP4 (CCE1) protein is part of native calcium release-activated Ca2+-like channels in adrenal cells. Philipp S, et al. J Biol Chem, 2000 Aug 4. PMID 10816590
    4. Elucidation of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement. Chaudhuri P, et al. Mol Biol Cell, 2008 Aug. PMID 18495872, Free PMC Article
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nitrix oxide can negatively modulate endogenous TRPC5-containing channels through an indirect mechanism.
      Title: Nitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells.
    2. analysis of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement
      Title: Elucidation of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables inositol 1,4,5 trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables store-operated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in manganese ion transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cation channel complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    short transient receptor potential channel 5
    Names
    transient receptor potential channel 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166574.1 → NP_001160046.1  short transient receptor potential channel 5

      See identical proteins and their annotated locations for NP_001160046.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000030
      UniProtKB/TrEMBL
      F1MTE6
      Related
      ENSBTAP00000013270.4, ENSBTAT00000013270.6
      Conserved Domains (2) summary
      TIGR00870
      Location:17 → 756
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:35 → 67
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      59966892..60322797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059883295.1 → XP_059739278.1  short transient receptor potential channel 5 isoform X1

      UniProtKB/TrEMBL
      F1MTE6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9MYV9.1 GenPept UniProtKB/Swiss-Prot:Q9MYV9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.