U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    HEM13 coproporphyrinogen oxidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851614, updated on 4-Feb-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    HEM13
    Gene description
    coproporphyrinogen oxidase
    Primary source
    SGD:S000002451
    Locus tag
    YDR044W
    See related
    AllianceGenome:SGD:S000002451
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables coproporphyrinogen oxidase activity. Involved in heme biosynthetic process. Located in cytosol. Human ortholog(s) of this gene implicated in hereditary coproporphyria and liver disease. Orthologous to human CPOX (coproporphyrinogen oxidase). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (546642..547628)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene transcriptional regulator NRG1 Neighboring gene DNA-directed RNA polymerase III core subunit RPC11 Neighboring gene amino acid transporter BAP3

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Characterization of an upstream activation sequence and two Rox1p-responsive sites controlling the induction of the yeast HEM13 gene by oxygen and heme deficiency. Amillet JM, et al. J Biol Chem, 1996 Oct 4. PMID 8798700
    2. Coproporphyrinogenase in a respiration-deficient mutant of yeast lacking all cytochromes and accumulating coproporphyrin. Miyake S, et al. J Bacteriol, 1968 Dec. PMID 5724967, Free PMC Article
    3. Aerobic and anaerobic coproporphyrinogenase activities in extracts from Saccharomyces cerevisiae. Poulson R, et al. J Biol Chem, 1974 Oct 25. PMID 4153629
    4. Purification and properties of coproporphyrinogen oxidase from the yeast Saccharomyces cerevisiae. Camadro JM, et al. Eur J Biochem, 1986 May 2. PMID 3516695
    5. Negative control of yeast coproporphyrinogen oxidase synthesis by heme and oxygen. Zagorec M, et al. J Biol Chem, 1986 Feb 25. PMID 3512538

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables coproporphyrinogen oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables coproporphyrinogen oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables coproporphyrinogen oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables coproporphyrinogen oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heme biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in porphyrin-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protoporphyrinogen IX biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protoporphyrinogen IX biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    coproporphyrinogen oxidase
    NP_010329.1
    • Coproporphyrinogen III oxidase; oxygen-requiring enzyme that catalyzes sixth step in heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p); human homolog CPOX can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      546642..547628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180352.1 → NP_010329.1  TPA: coproporphyrinogen oxidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010329.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS32, P11353
      UniProtKB/TrEMBL
      A0A6A5PY90, A6ZY11, B3LGM3, B5VFU6, C7GTA5, C8Z4W4, N1PAC1
      Conserved Domains (1) summary
      pfam01218
      Location:15 → 327
      Coprogen_oxidas; Coproporphyrinogen III oxidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11353.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous