TUBA1C tubulin alpha 1c [Homo sapiens (human)] - Gene

Summary

Official Symbol: TUBA1Cprovided by HGNC
Official Full Name: tubulin alpha 1cprovided by HGNC
Primary source: HGNC:HGNC:20768
See related: Ensembl:ENSG00000167553 AllianceGenome:HGNC:20768
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TUBA6; bcm948
Summary: Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in microtubule cytoskeleton and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in esophagus (RPKM 168.9), bone marrow (RPKM 156.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q13.12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (49227926..49274600)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (49190111..49236791)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (49621709..49668383)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TUBA1C: a new potential target of LncRNA EGFR-AS1 promotes gastric cancer progression.
Title: TUBA1C: a new potential target of LncRNA EGFR-AS1 promotes gastric cancer progression.
The oncogenic role of tubulin alpha-1c chain in human tumours.
Title: The oncogenic role of tubulin alpha-1c chain in human tumours.
Tubulin alpha 1c promotes aerobic glycolysis and cell growth through upregulation of yes association protein expression in breast cancer.
Title: Tubulin alpha 1c promotes aerobic glycolysis and cell growth through upregulation of yes association protein expression in breast cancer.
TUBA1C expression promotes proliferation by regulating the cell cycle and indicates poor prognosis in glioma.
Title: TUBA1C expression promotes proliferation by regulating the cell cycle and indicates poor prognosis in glioma.
Circular RNA TUBA1C accelerates the progression of non-small-cell lung cancer by sponging miR-143-3p.
Title: Circular RNA TUBA1C accelerates the progression of non-small-cell lung cancer by sponging miR-143-3p.
Tektin4 loss promotes triple-negative breast cancer metastasis through HDAC6-mediated tubulin deacetylation and increases sensitivity to HDAC6 inhibitor.
Title: Tektin4 loss promotes triple-negative breast cancer metastasis through HDAC6-mediated tubulin deacetylation and increases sensitivity to HDAC6 inhibitor.
These results suggest that tubulin alpha-6 chain is one of the candidates for biomarkers for well-differentiated hepatitis C virus-associated human hepatocellular carcinoma.
Title: Up-regulation of 42 kDa tubulin alpha-6 chain fragment in well-differentiated hepatocellular carcinoma tissues from patients infected with hepatitis C virus.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of tubulin, alpha 1c (TUBA1C) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	The binding of HIV-1 gp120 to CD4+-permissive cells increases the level of acetylated alpha-tubulin in a CD4-dependent manner; overexpression of Histone Deacetylase 6 (HDAC6) inhibits the acetylation of alpha-tubulin and prevents HIV-1-cell fusion	PubMed
Envelope surface glycoprotein gp160, precursor	env	Treatment of cells with actin-depolymerizing agents or tubulin polymerization inhibitors largely reduces the percentage of cells with capped HIV-1 Gag and Env, indicating an intact actin and tubulin cytoskeleton is required for efficient assembly of HIV-1	PubMed
Envelope transmembrane glycoprotein gp41	env	Expression of HIV-1 gp41 cytoplasmic domain reduces acetylated tubulin alpha and interferes with virus-cell fusion	PubMed
Pr55(Gag)	gag	Treatment of cells with actin-depolymerizing agents or tubulin polymerization inhibitors largely reduces the percentage of cells with capped HIV-1 Gag and Env, indicating an intact actin and tubulin cytoskeleton is required for efficient assembly of HIV-1	PubMed
Rev	rev	HIV-1 Rev interacting protein, tubulin alpha 1c (TUBA1C), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells	PubMed
	rev	Rev acts to depolymerize microtubules that are formed by tubulin, an effect that is observed during HIV-1 infection	PubMed
Tat	tat	HIV-1 Tat causes a dramatic decrease in alpha-tubulin staining, which indicates disruption of the cytoskeleton organization in human intestinal epithelial cells	PubMed
	tat	HIV-1 Tat (specifically, amino acids 38-72), enhances tubulin polymerization and triggers the mitochondrial pathway to induce T cell apoptosis as shown in vitro by the release of cytochrome c from isolated mitochondria	PubMed
	tat	HIV-1 Tat (amino acids 36-39) binds tubulin alpha/beta dimers and polymerized microtubules leading to the alteration of microtubule dynamics and activation of a mitochondria-dependent apoptotic pathway that is facilitated by the Bcl-2 relative Bim	PubMed
integrase	gag-pol	Co-immunoprecipitation shows interaction of HIV-1 IN with alpha-tubulin	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D22S1042 (e-PCR)
- UniSTS:67652

A002J21 (e-PCR)
- UniSTS:23364

RH48063 (e-PCR)
- UniSTS:67653

PMC154451P2 (e-PCR)
- UniSTS:271312

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural molecule activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	TAS Traceable Author Statement more info	PubMed
involved_in cytoskeleton-dependent intracellular transport	TAS Traceable Author Statement more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based process	TAS Traceable Author Statement more info	PubMed
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic microtubule	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	TAS Traceable Author Statement more info	PubMed
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	HDA more info	PubMed

General protein information

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Preferred Names: tubulin alpha-1C chain

Names: alpha-tubulin 6; tubulin alpha-6 chain; tubulin, alpha 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001303114.1 → NP_001290043.1 tubulin alpha-1C chain isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AC125611, AK293589, AW150119

Consensus CDS

CCDS76556.1

UniProtKB/TrEMBL

B7Z1K5, F5H5D3

Related

ENSP00000443475.1, ENST00000541364.5

Conserved Domains (2) summary

PTZ00335
Location:72 → 518

PTZ00335; tubulin alpha chain; Provisional

cd02186
Location:72 → 505

alpha_tubulin; The alpha-tubulin family
NM_001303115.2 → NP_001290044.1 tubulin alpha-1C chain isoform b

See identical proteins and their annotated locations for NP_001290044.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains alternate exons in the 5' end and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).

Source sequence(s)

AC125611, AK293589, AW150119, DA686435

UniProtKB/TrEMBL

B3KPS3

Conserved Domains (1) summary

PTZ00335
Location:1 → 413

PTZ00335; tubulin alpha chain; Provisional
NM_001303116.2 → NP_001290045.1 tubulin alpha-1C chain isoform b

See identical proteins and their annotated locations for NP_001290045.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate exon in the 5' end and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).

Source sequence(s)

AC125611, AK293589, AL539200, AW150119

UniProtKB/TrEMBL

B3KPS3

Conserved Domains (1) summary

PTZ00335
Location:1 → 413

PTZ00335; tubulin alpha chain; Provisional
NM_001303117.2 → NP_001290046.1 tubulin alpha-1C chain isoform b

See identical proteins and their annotated locations for NP_001290046.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate exon in the 5' end and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).

Source sequence(s)

AC125611, AK293589, AW150119, DC366449

UniProtKB/TrEMBL

B3KPS3

Conserved Domains (1) summary

PTZ00335
Location:1 → 413

PTZ00335; tubulin alpha chain; Provisional
NM_032704.5 → NP_116093.1 tubulin alpha-1C chain isoform c

See identical proteins and their annotated locations for NP_116093.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) contains an alternate first exon in place of the first exon of variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AC125611, AW150119, BC005946

Consensus CDS

CCDS8782.1

UniProtKB/Swiss-Prot

Q9BQE3

UniProtKB/TrEMBL

Q53GA7

Related

ENSP00000301072.7, ENST00000301072.11

Conserved Domains (1) summary

PTZ00335
Location:1 → 448

PTZ00335; tubulin alpha chain; Provisional