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    cd74a CD74 molecule, major histocompatibility complex, class II invariant chain a [ Danio rerio (zebrafish) ]

    Gene ID: 58113, updated on 27-Mar-2024

    Summary

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    Official Symbol
    cd74aprovided by ZNC
    Official Full Name
    CD74 molecule, major histocompatibility complex, class II invariant chain aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000901-1
    See related
    Ensembl:ENSDARG00000009087 AllianceGenome:ZFIN:ZDB-GENE-000901-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    iclp1; Iclp-1; wu:fb11f09; wu:fb12a01; wu:fb13d06; wu:fk94e07
    Summary
    Predicted to enable MHC class II protein binding activity; cytokine receptor activity; and macrophage migration inhibitory factor binding activity. Acts upstream of or within T cell activation involved in immune response; dendritic cell antigen processing and presentation; and sensory organ development. Located in cell surface. Is expressed in dendritic cell; otic vesicle; pectoral fin bud; pharyngeal arch; and sensory system. Orthologous to human CD74 (CD74 molecule). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    Location:
    chromosome: 14
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (3038597..3052361)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (2787480..2801244)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene bicaudal C homolog 2 Neighboring gene N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1a Neighboring gene si:dkey-201i24.3 Neighboring gene solute carrier family 35 member A4 Neighboring gene HMG box domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Ancient features of the MHC class II presentation pathway, and a model for the possible origin of MHC molecules. Dijkstra JM, et al. Immunogenetics, 2019 Mar. PMID 30377750
    2. Identification of dendritic antigen-presenting cells in the zebrafish. Lugo-Villarino G, et al. Proc Natl Acad Sci U S A, 2010 Sep 7. PMID 20733076, Free PMC Article
    3. The cytokine macrophage migration inhibitory factor (MIF) acts as a neurotrophin in the developing inner ear of the zebrafish, Danio rerio. Shen YC, et al. Dev Biol, 2012 Mar 1. PMID 22210003, Free PMC Article
    4. Transcriptome Analysis Reveals Increases in Visceral Lipogenesis and Storage and Activation of the Antigen Processing and Presentation Pathway during the Mouth-Opening Stage in Zebrafish Larvae. Xu H, et al. Int J Mol Sci, 2017 Jul 31. PMID 28758957, Free PMC Article
    5. Effects of acute and chronic arecoline in adult zebrafish: Anxiolytic-like activity, elevated brain monoamines and the potential role of microglia. Serikuly N, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2021 Jan 10. PMID 32454162

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables MHC class II protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MHC class II protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables macrophage migration inhibitory factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables macrophage migration inhibitory factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within T cell activation involved in immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in antigen processing and presentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within antigen processing and presentation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within dendritic cell antigen processing and presentation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within inner ear development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuromast development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of macrophage cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of type 2 immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CD74 molecule, major histocompatibility complex, class II invariant chain a
    Names
    MHC II
    invariant chain-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131590.2 → NP_571665.1  CD74 molecule, major histocompatibility complex, class II invariant chain a

      See identical proteins and their annotated locations for NP_571665.1

      Status: VALIDATED

      Source sequence(s)
      CU468924
      UniProtKB/TrEMBL
      Q6P0V5, Q9PUT2
      Related
      ENSDARP00000002547.6, ENSDART00000026021.8
      Conserved Domains (2) summary
      cd00191
      Location:177 → 234
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam09307
      Location:4 → 109
      MHC2-interact; CLIP, MHC2 interacting

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      3038597..3052361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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