Hspb6 heat shock protein, alpha-crystallin-related, B6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hspb6provided by MGI
Official Full Name: heat shock protein, alpha-crystallin-related, B6provided by MGI
Primary source: MGI:MGI:2685325
See related: Ensembl:ENSMUSG00000036854 AllianceGenome:MGI:2685325
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm479; Hsp20
Summary: Predicted to enable chaperone binding activity; protein homodimerization activity; and unfolded protein binding activity. Predicted to be involved in chaperone-mediated protein folding; negative regulation of cardiac muscle cell apoptotic process; and positive regulation of angiogenesis. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and nucleolus. Is expressed in brain subventricular zone; lung; retina inner nuclear layer; retina outer nuclear layer; and smooth muscle tissue. Orthologous to human HSPB6 (heat shock protein family B (small) member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 535.2), mammary gland adult (RPKM 143.4) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 18.56 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (30251961..30254868)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (30552535..30555443)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HSPB6 Deficiency Promotes the Development of Aortic Dissection and Rupture.
Title: HSPB6 Deficiency Promotes the Development of Aortic Dissection and Rupture.
The Cardioprotective PKA-Mediated Hsp20 Phosphorylation Modulates Protein Associations Regulating Cytoskeletal Dynamics.
Title: The Cardioprotective PKA-Mediated Hsp20 Phosphorylation Modulates Protein Associations Regulating Cytoskeletal Dynamics.
HSP20-mediated cardiomyocyte exosomes improve cardiac function in mice with myocardial infarction by activating Akt signaling pathway.
Title: HSP20-mediated cardiomyocyte exosomes improve cardiac function in mice with myocardial infarction by activating Akt signaling pathway.
Hsp20-S10F mice treated with probenecid had decreased mortality, hypertrophy, TRPV2 expression and molecular parameters of heart failure.
Title: Probenecid treatment improves outcomes in a novel mouse model of peripartum cardiomyopathy.
These findings suggest a role of Hsp20 in mediating adipocyte function by linking beta-adrenergic signaling to PPARgamma activity.
Title: An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPARγ Ubiquitination.
Our study was designed to assess the efficacy of small heat shock proteins B1 (Hsp27) and B6 (Hsp20) as an adjuvant accompanied by HPV16 E7 and hPP10-E7 antigens in tumor mouse model. A major key for successful DNA and protein transfer into cells is the development of delivery systems with high efficiency and low cytotoxicity.
Title: Small Heat Shock Proteins B1 and B6: Which One is the Most Effective Adjuvant in Therapeutic HPV Vaccine?
Increased expression of Hsp20 in neuroblastoma cells protected against ischemia-reperfusion injury.
Title: Blockade of Ser16-Hsp20 phosphorylation attenuates neuroprotection dependent upon Bcl-2 and Bax.
potential protein targets for the loss of PostC may include F(1)-ATPase gamma, Echs1 and Hsp20 that could regulate cellular ATP consumption/production and defense response to ischaemic stress
Title: Type 2 diabetic obese db/db mice are refractory to myocardial ischaemic post-conditioning in vivo: potential role for Hsp20, F1-ATPase δ and Echs1.
the activity of type 1 protein phosphatase (PP1), a known regulator of PLN signaling, was significantly reduced by Hsp20 overexpression, suggesting that the Hsp20 stimulatory effects are partially mediated through the PP1-PLN axis.
Title: Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling.
Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death.
Title: Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:488522

NoName (e-PCR)
- UniSTS:235646

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein folding chaperone	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of eye lens	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: heat shock protein beta-6

Names: cardiac heat shock protein p20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012401.3 → NP_001012401.1 heat shock protein beta-6 isoform 1

See identical proteins and their annotated locations for NP_001012401.1

Status: VALIDATED

Source sequence(s)

BC089621, BQ176401, CK627709

Consensus CDS

CCDS21097.1

UniProtKB/Swiss-Prot

Q5EBG6

Related

ENSMUSP00000039172.8, ENSMUST00000044048.8

Conserved Domains (2) summary

cd06478
Location:66 → 148

ACD_HspB4-5-6; Alpha-crystallin domain found in alphaA-crystallin (HspB4), alphaB-crystallin (HspB5), and the small heat shock protein (sHsp) HspB6, also known as Hsp20. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, ...

pfam00525
Location:5 → 56

Crystallin; Alpha crystallin A chain, N terminal
NM_001364179.1 → NP_001351108.1 heat shock protein beta-6 isoform 2

Status: VALIDATED

Source sequence(s)

AK144390, BQ176401

UniProtKB/TrEMBL

Q3UN84

Related

ENSMUST00000126989.8

Conserved Domains (1) summary

cl00175
Location:8 → 89

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

RNA

NR_157095.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) is represented as non-coding because it lacks the open reading frame found in variant 1.

Source sequence(s)

BC051228, BQ176401, BY198268

Related

ENSMUST00000123355.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

30251961..30254868

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539957.5 → XP_006540020.1 heat shock protein beta-6 isoform X1

Conserved Domains (1) summary

cd06478
Location:47 → 129

ACD_HspB4-5-6; Alpha-crystallin domain found in alphaA-crystallin (HspB4), alphaB-crystallin (HspB5), and the small heat shock protein (sHsp) HspB6, also known as Hsp20. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, ...