Mbl2 mannose binding lectin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Mbl2provided by RGD
Full Name: mannose binding lectin 2provided by RGD
Primary source: RGD:67380
See related: AllianceGenome:RGD:67380
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ab2-001; Ab2-011
Summary: Enables several functions, including identical protein binding activity; monosaccharide binding activity; and phosphatidylinositol-4-phosphate binding activity. Involved in positive regulation of complement activation and positive regulation of protein processing. Located in extracellular space. Part of protein-containing complex. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bacterial infectious disease (multiple); fungal infectious disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human MBL2 (mannose binding lectin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1618.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q52

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (237429873..237465567)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (228016439..228024736)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (248435069..248442669)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D11440 (e-PCR)
- UniSTS:163611

AA893453 (e-PCR)
- UniSTS:250094

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables galactose binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mannose binding	IDA Inferred from Direct Assay more info	PubMed
enables mannose binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4-phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in cell surface pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within complement activation, lectin pathway	ISO Inferred from Sequence Orthology more info
involved_in complement activation, lectin pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within killing by host of symbiont cells	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of complement activation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of opsonization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein processing	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in surfactant homeostasis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in multivesicular body	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of serine-type endopeptidase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mannose-binding protein C

Names: MBP-C; RA-reactive factor P28A subunit; RARF/P28A; mannan-binding protein; mannose binding lectin 2 (protein C); mannose-binding lectin (protein C) 2; mannose-binding protein C (liver); mannose-binding protein C-like; ra-reactive factor polysaccharide-binding component p28A; raRF p28A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022704.2 → NP_073195.2 mannose-binding protein C precursor

See identical proteins and their annotated locations for NP_073195.2

Status: PROVISIONAL

Source sequence(s)

X05023

UniProtKB/Swiss-Prot

P08661

UniProtKB/TrEMBL

A6I0Y6

Conserved Domains (2) summary

cd03591
Location:132 → 242

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

pfam01391
Location:36 → 95

Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

237429873..237465567

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231249.4 → XP_006231311.1 mannose-binding protein C isoform X1

See identical proteins and their annotated locations for XP_006231311.1

UniProtKB/Swiss-Prot

P08661

UniProtKB/TrEMBL

A6I0Y6

Conserved Domains (2) summary

cd03591
Location:132 → 242

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

pfam01391
Location:36 → 95

Collagen; Collagen triple helix repeat (20 copies)
XM_063272804.1 → XP_063128874.1 mannose-binding protein C isoform X2
XM_006231250.4 → XP_006231312.1 mannose-binding protein C isoform X1

See identical proteins and their annotated locations for XP_006231312.1

UniProtKB/Swiss-Prot

P08661

UniProtKB/TrEMBL

A6I0Y6

Conserved Domains (2) summary

cd03591
Location:132 → 242

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

pfam01391
Location:36 → 95

Collagen; Collagen triple helix repeat (20 copies)