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    Cdcp1 CUB domain containing protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 109332, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cdcp1provided by MGI
    Official Full Name
    CUB domain containing protein 1provided by MGI
    Primary source
    MGI:MGI:2442010
    See related
    Ensembl:ENSMUSG00000035498 AllianceGenome:MGI:2442010
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9030022E12Rik; E030027H19Rik
    Summary
    Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including adenohypophysis; alimentary system; bladder fundus; respiratory system; and sensory organ. Orthologous to human CDCP1 (CUB domain containing protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 12.9), colon adult (RPKM 10.2) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdcp1 in Genome Data Viewer
    Location:
    9 F4; 9 73.92 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (122999870..123045175, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (123170805..123216110, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 3, member b Neighboring gene predicted gene, 23323 Neighboring gene STARR-seq mESC enhancer starr_25558 Neighboring gene STARR-seq mESC enhancer starr_25559 Neighboring gene STARR-seq mESC enhancer starr_25560 Neighboring gene transmembrane protein 158 Neighboring gene STARR-seq mESC enhancer starr_25561 Neighboring gene sterol carrier protein 2, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CDCP1 regulates retinal pigmented epithelial barrier integrity for the development of experimental autoimmune uveitis. Zhang L, et al. JCI Insight, 2022 Sep 22. PMID 35951427, Free PMC Article
    2. CDCP1 on Dendritic Cells Contributes to the Development of a Model of Kawasaki Disease. Lun Y, et al. J Immunol, 2021 Jun 15. PMID 34099547, Free PMC Article
    3. CDCP1 expression is frequently increased in aggressive urothelial carcinoma and promotes urothelial tumor progression. Saponaro M, et al. Sci Rep, 2023 Jan 2. PMID 36593286, Free PMC Article
    4. CD318 is a ligand for CD6. Enyindah-Asonye G, et al. Proc Natl Acad Sci U S A, 2017 Aug 15. PMID 28760953, Free PMC Article
    5. Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cells. Spassov DS, et al. Cancer Res, 2013 Feb 1. PMID 23243018, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CDCP1 expression is frequently increased in aggressive urothelial carcinoma and promotes urothelial tumor progression.
      Title: CDCP1 expression is frequently increased in aggressive urothelial carcinoma and promotes urothelial tumor progression.
    2. CDCP1 regulates retinal pigmented epithelial barrier integrity for the development of experimental autoimmune uveitis.
      Title: CDCP1 regulates retinal pigmented epithelial barrier integrity for the development of experimental autoimmune uveitis.
    3. CDCP1 on Dendritic Cells Contributes to the Development of a Model of Kawasaki Disease.
      Title: CDCP1 on Dendritic Cells Contributes to the Development of a Model of Kawasaki Disease.
    4. CDCP1 promotes compensatory renal growth by integrating Src and Met signaling.
      Title: CDCP1 promotes compensatory renal growth by integrating Src and Met signaling.
    5. Results indicate Cdcp1 (CD318) as a ligand of T-cell differentiation antigen CD6 (CD6) and a potential target for the diagnosis and treatment of autoimmune diseases.
      Title: CD318 is a ligand for CD6.
    6. Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cells.
      Title: Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cells.
    7. established mechanism for initiation of CDCP1-mediated signaling; demonstrated that processing of surface CDCP1 by extracellular serine proteases is prerequisite for CDCP1-dependent survival of cancer cells during metastasis; preventing cleavage of CDCP1 abrogated survival signaling associated with CDCP1 and induced PARP1 cleavage and PARP1-mediated apoptosis
      Title: Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells.
    8. CDCP1 may have a role in neoplasm metastasis; targeting it with a monoclonal antibody inhibits metastasis in a prostate cancer model
      Title: Targeting CUB domain-containing protein 1 with a monoclonal antibody inhibits metastasis in a prostate cancer model.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CUB domain-containing protein 1
    Names
    membrane glycoprotein gp140
    transmembrane and associated with src kinases

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133974.3 → NP_598735.2  CUB domain-containing protein 1 precursor

      See identical proteins and their annotated locations for NP_598735.2

      Status: PROVISIONAL

      Source sequence(s)
      AC134248
      Consensus CDS
      CCDS23657.1
      UniProtKB/Swiss-Prot
      Q5U462, Q810J0, Q921M9
      UniProtKB/TrEMBL
      Q05D42
      Related
      ENSMUSP00000042057.8, ENSMUST00000039229.8
      Conserved Domains (1) summary
      cl00049
      Location:225 → 297
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      122999870..123045175 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511921.3 → XP_006511984.1  CUB domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      Q05D42
      Conserved Domains (1) summary
      cl00049
      Location:224 → 296
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    2. XM_006511922.3 → XP_006511985.1  CUB domain-containing protein 1 isoform X2

      Conserved Domains (1) summary
      cl00049
      Location:166 → 238
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U462.1 GenPept UniProtKB/Swiss-Prot:Q5U462

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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