RAC1 Rac family small GTPase 1 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: RAC1provided by VGNC
Official Full Name: Rac family small GTPase 1provided by VGNC
Primary source: VGNC:VGNC:106889
See related: Ensembl:ENSBTAG00000053390
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	25	NC_037352.1 (38278421..38297359)

Chromosome 25 - NC_037352.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037352.1 Chromosome 25 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rac1 modification by electrophiles such as 15-deoxy-delta(12,14)-prostaglandin J2 may alter redox signaling and vascular endothelial cells function.
Title: Rac1 modification by an electrophilic 15-deoxy Δ(12,14)-prostaglandin J2 analog.
Sig1R through Rac1 signaling induces mild oxidative stress that possibly is involved in the regulation of neuroplasticity
Title: Sigma-1 receptor directly interacts with Rac1-GTPase in the brain mitochondria.
a critical role for H(2)O(2) in angiotensin-II signaling to the endothelial cytoskeleton in a novel pathway that is critically dependent on MARCKS, Rac1, and c-Abl.
Title: Angiotensin-II and MARCKS: a hydrogen peroxide- and RAC1-dependent signaling pathway in vascular endothelium.
the activation of Rac1 due to the cell-cell contact plays a critical role in the transcriptional up-regulation of p27Kip1 in vascular endothelial cells.
Title: Rac1-dependent transcriptional up-regulation of p27Kip1 by homophilic cell-cell contact in vascular endothelial cells.
small G protein Rac1 is a key regulator of beta(3)Adrenergic receptor signaling in cultured aortic endothelial cells with potentially important implications for the pathways involved in adrenergic modulation of eNOS pathways in the vascular wall
Title: Epinephrine regulation of the endothelial nitric-oxide synthase: roles of RAC1 and beta3-adrenergic receptors in endothelial NO signaling.
Cadherins, RhoA and Rac1, have important roles in mechanotransduction and that endothelial and smooth muscle cells use different mechanisms to respond to stretch.
Title: Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells.
G protein betagamma subunits, Src kinase and the GEF Tiam1 are upstream modulators of S1P-mediated Rac1 activation, and Rac1 has a role in S1P-mediated activation of PI 3-kinase/Akt/endothelial nitric-oxide synthase signaling in vascular endothelial cells
Title: Rac1 modulates sphingosine 1-phosphate-mediated activation of phosphoinositide 3-kinase/Akt signaling pathways in vascular endothelial cells.
Rac1 was activated by secretory stimuli and modulated the secretory pathway downstream of Ca2+ influx, partly through regulation of cytoskeletal organization
Title: Facilitation of Ca(2+)-dependent exocytosis by Rac1-GTPase in bovine chromaffin cells.
Rac1 only partially restores the spreading defects of integrin linked kinasse (ILK)-depleted cells, suggesting that an additional ILK-dependent signal is required for cell spreading.
Title: Regulation of cell-matrix adhesion dynamics and Rac-1 by integrin linked kinase.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cortical cytoskeleton organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in establishment or maintenance of cell polarity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in motor neuron axon guidance	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info	PubMed
located_in dendritic spine	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: ras-related C3 botulinum toxin substrate 1

Names: p21-Rac1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); rho family, small GTP binding protein Rac1

NP_776588.1

EC 3.6.5.2

XP_024840414.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174163.2 → NP_776588.1 ras-related C3 botulinum toxin substrate 1

See identical proteins and their annotated locations for NP_776588.1

Status: PROVISIONAL

Source sequence(s)

AF175262

UniProtKB/Swiss-Prot

P62998, Q3ZBW9

UniProtKB/TrEMBL

F1MNG3

Related

ENSBTAP00000012170.7, ENSBTAT00000012170.7

Conserved Domains (1) summary

cd01871
Location:3 → 176

Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037352.1 Reference ARS-UCD2.0 Primary Assembly

Range

38278421..38297359

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024984646.2 → XP_024840414.1 ras-related C3 botulinum toxin substrate 1 isoform X1

UniProtKB/TrEMBL

A0A3Q1LXR2, F1MNG3

Related

ENSBTAP00000062007.1, ENSBTAT00000080696.2

Conserved Domains (1) summary

cd01871
Location:3 → 195

Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3