Slc30a3 solute carrier family 30 member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc30a3provided by RGD
Official Full Name: solute carrier family 30 member 3provided by RGD
Primary source: RGD:1359689
See related: Ensembl:ENSRNOG00000006204 AllianceGenome:RGD:1359689
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ZnT3
Summary: Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in regulation of sequestering of zinc ion; response to zinc ion; and zinc ion import into synaptic vesicle. Predicted to act upstream of or within positive regulation of transport. Predicted to be located in hippocampal mossy fiber; late endosome; and synaptic vesicle membrane. Predicted to be active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and plasma membrane. Predicted to be integral component of synaptic vesicle membrane. Orthologous to human SLC30A3 (solute carrier family 30 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 80.7), Brain (RPKM 59.8) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q14

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (30984241..31004689)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (25264310..25284720)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (26629752..26650106)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression profile of the zinc transporter ZnT3 in taste cells of rat circumvallate papillae and its role in zinc release, a potential mechanism for taste stimulation.
Title: Expression profile of the zinc transporter ZnT3 in taste cells of rat circumvallate papillae and its role in zinc release, a potential mechanism for taste stimulation.
The ZnT3/CB-D28k-associated Zn (2+)/Ca(2+) signaling might be involved in neonatal SE-induced long-term brain damage in the aspects of neurobehavioral impairment.
Title: Alterations in the Neurobehavioral Phenotype and ZnT3/CB-D28k Expression in the Cerebral Cortex Following Lithium-Pilocarpine-Induced Status Epilepticus: the Ameliorative Effect of Leptin.
rats treated with KD (EXP2) showed a significant down-regulated expression of ZnT-3, MT-3, ApoE, clusterin, and ACAT-1 in hippocampus
Title: Neurobehavioral Deficits in a Rat Model of Recurrent Neonatal Seizures Are Prevented by a Ketogenic Diet and Correlate with Hippocampal Zinc/Lipid Transporter Signals.
zinc homeostasis dysfunction by decreased expression of ZnT3 or ZnT10 promotes senescence of vascular smooth muscle cells.
Title: Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells.
Both ZnT3 and ZnT8 seem to play a role in beta-cell survival and the ability of these cells to react appropriately to surrounding glucose concentrations.
Title: siRNA-mediated knock-down of ZnT3 and ZnT8 affects production and secretion of insulin and apoptosis in INS-1E cells.
These data are consistent with an important role for ZnT-1, ZnT-3 and PRG-1 in the pathophysiology of the long-term adverse effects of recurrent neonatal seizure-induced hippocampal mossy fiber sprouting and cognitive deficit.
Title: Dynamic pattern of gene expression of ZnT-1, ZnT-3 and PRG-1 in rat brain following flurothyl-induced recurrent neonatal seizures.
SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity
Title: SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity.
ZnT-1, ZnT-3, CaMK II, PRG-1 expressions in hippocampus following neonatal seizure-induced cognitive deficit in rats.
Title: ZnT-1, ZnT-3, CaMK II, PRG-1 expressions in hippocampus following neonatal seizure-induced cognitive deficit in rats.
the coupling of zinc transporter 3 and Vglut1 transport mechanisms regulates neurotransmitter content in secretory vesicles
Title: Vglut1 and ZnT3 co-targeting mechanisms regulate vesicular zinc stores in PC12 cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transport	ISO Inferred from Sequence Orthology more info
involved_in response to zinc ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion import into lysosome	IEA Inferred from Electronic Annotation more info
involved_in zinc ion import into lysosome	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into synaptic vesicle	IEA Inferred from Electronic Annotation more info
involved_in zinc ion import into synaptic vesicle	ISO Inferred from Sequence Orthology more info
involved_in zinc ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in zinc ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in hippocampal mossy fiber	IEA Inferred from Electronic Annotation more info
located_in hippocampal mossy fiber	ISO Inferred from Sequence Orthology more info
located_in hippocampal mossy fiber to CA3 synapse	IEA Inferred from Electronic Annotation more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in microvesicle	IEA Inferred from Electronic Annotation more info
is_active_in microvesicle	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: probable proton-coupled zinc antiporter SLC30A3

Names: solute carrier family 30 (zinc transporter), member 3; solute carrier family 30 protein; zinc transporter 3; zinc transporter ZnT-3; znT-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013243.1 → NP_001013261.1 probable proton-coupled zinc antiporter SLC30A3

See identical proteins and their annotated locations for NP_001013261.1

Status: PROVISIONAL

Source sequence(s)

AY538655

UniProtKB/Swiss-Prot

Q5RJT1, Q6QIX3

UniProtKB/TrEMBL

A0A8I6AD52

Related

ENSRNOP00000008126.5, ENSRNOT00000008126.8

Conserved Domains (2) summary

TIGR01297
Location:85 → 372

CDF; cation diffusion facilitator family transporter

pfam01545
Location:85 → 293

Cation_efflux; Cation efflux family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

30984241..31004689

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039112621.2 → XP_038968549.1 probable proton-coupled zinc antiporter SLC30A3 isoform X1

UniProtKB/TrEMBL

A0A8I6AD52

Conserved Domains (1) summary

TIGR01297
Location:36 → 323

CDF; cation diffusion facilitator family transporter
XM_008764526.4 → XP_008762748.1 probable proton-coupled zinc antiporter SLC30A3 isoform X1

See identical proteins and their annotated locations for XP_008762748.1

UniProtKB/TrEMBL

A0A8I6AD52

Conserved Domains (1) summary

TIGR01297
Location:36 → 323

CDF; cation diffusion facilitator family transporter
XM_039112622.2 → XP_038968550.1 probable proton-coupled zinc antiporter SLC30A3 isoform X1

UniProtKB/TrEMBL

A0A8I6AD52

Conserved Domains (1) summary

TIGR01297
Location:36 → 323

CDF; cation diffusion facilitator family transporter
XM_008764527.4 → XP_008762749.1 probable proton-coupled zinc antiporter SLC30A3 isoform X1

See identical proteins and their annotated locations for XP_008762749.1

UniProtKB/TrEMBL

A0A8I6AD52

Conserved Domains (1) summary

TIGR01297
Location:36 → 323

CDF; cation diffusion facilitator family transporter
XM_008764528.3 → XP_008762750.1 probable proton-coupled zinc antiporter SLC30A3 isoform X1

See identical proteins and their annotated locations for XP_008762750.1

UniProtKB/TrEMBL

A0A8I6AD52

Conserved Domains (1) summary

TIGR01297
Location:36 → 323

CDF; cation diffusion facilitator family transporter