Prom2 prominin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prom2provided by MGI
Official Full Name: prominin 2provided by MGI
Primary source: MGI:MGI:2138997
See related: Ensembl:ENSMUSG00000027376 AllianceGenome:MGI:2138997
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Prom-rp
Summary: Predicted to enable cholesterol binding activity. Predicted to be involved in several processes, including negative regulation of endocytosis; positive regulation of protein phosphorylation; and regulation of GTPase activity. Located in cell surface; plasma membrane; and prominosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and naris epithelium. Orthologous to human PROM2 (prominin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 207.3), bladder adult (RPKM 49.2) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 62.04 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (127368873..127383337, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (127526953..127541417, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show the distribution and subcellular localization of prominin-2 within the kidney in situ.
Title: Prominin-2 is a novel marker of distal tubules and collecting ducts of the human and murine kidney.
Prominin-2 is widely and abundantly expressed along the epithelia of various segments of the adult male genitourinary tract.
Title: Robust expression of Prominin-2 all along the adult male reproductive system and urinary bladder.
expression Prominin-2, in the three pairs of major salivary glands, i.e., submandibular-, major sublingual-, and parotid glands in adult mice.
Title: Differential expression of Prominin-1 (CD133) and Prominin-2 in major cephalic exocrine glands of adult mice.
These data show that all the characteristics of prominin-1 are shared by prominin-2, which is in agreement with a possible redundancy in their role as potential organizers of plasma membrane protrusions.
Title: Prominin-2 is a cholesterol-binding protein associated with apical and basolateral plasmalemmal protrusions in polarized epithelial cells and released into urine.
identification as well as molecular and cell biological characterization
Title: Characterization of prominin-2, a new member of the prominin family of pentaspan membrane glycoproteins.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cholesterol binding	IBA Inferred from Biological aspect of Ancestor more info
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables cholesterol binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of caveolin-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of pinocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell projection organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of GTPase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with membrane raft	ISO Inferred from Sequence Orthology more info
colocalizes_with membrane raft	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in microspike	ISO Inferred from Sequence Orthology more info
located_in microspike	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in prominosome	IBA Inferred from Biological aspect of Ancestor more info
located_in prominosome	IDA Inferred from Direct Assay more info	PubMed
located_in prominosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prominin-2

Names: PROM-2; mPROML2; prominin-like protein 2; prominin-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138750.2 → NP_620089.2 prominin-2 isoform 1 precursor

See identical proteins and their annotated locations for NP_620089.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK029851, AK137749, CJ045574

Consensus CDS

CCDS16704.1

UniProtKB/Swiss-Prot

A2AHT1, Q3UUY6, Q8CDM5, Q8CHT5, Q8R4Y7, Q9WUC7

Related

ENSMUSP00000028855.8, ENSMUST00000028855.14

Conserved Domains (1) summary

pfam05478
Location:29 → 808

Prominin; Prominin
NM_178047.4 → NP_835148.2 prominin-2 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK029851, AK137749, BQ900846, CJ045574

Consensus CDS

CCDS50704.1

UniProtKB/Swiss-Prot

Q3UUY6

Related

ENSMUSP00000099503.3, ENSMUST00000103214.3

Conserved Domains (1) summary

pfam05478
Location:29 → 808

Prominin; Prominin