Parp8 poly (ADP-ribose) polymerase family, member 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Parp8provided by MGI
Official Full Name: poly (ADP-ribose) polymerase family, member 8provided by MGI
Primary source: MGI:MGI:1098713
See related: Ensembl:ENSMUSG00000021725 AllianceGenome:MGI:1098713
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ARTD16; D13Ertd275e; 2810430O08Rik
Summary: Predicted to enable NAD+ ADP-ribosyltransferase activity and protein ADP-ribosylase activity. Predicted to be involved in protein auto-ADP-ribosylation and protein mono-ADP-ribosylation. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and sensory organ. Orthologous to human PARP8 (poly(ADP-ribose) polymerase family member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E18 (RPKM 8.9), CNS E14 (RPKM 6.0) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D2.3; 13 65.32 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (116987378..117162549, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (116850842..117026019, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

General gene information

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Markers

UniSTS:237113 (e-PCR)
- UniSTS:237113

D13Mit77 (e-PCR), detects polymorphism
- UniSTS:116562

D13Ertd275e (e-PCR), detects polymorphism
- UniSTS:167104

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD+ ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein auto-ADP-ribosylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum tubular network	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein mono-ADP-ribosyltransferase PARP8

Names: ADP-ribosyltransferase diphtheria toxin-like 16; PARP-8; poly [ADP-ribose] polymerase 8

NP_001074478.3

EC 2.4.2.30

NP_001413994.1

EC 2.4.2.30

NP_001413995.1

EC 2.4.2.30

NP_001413996.1

EC 2.4.2.30

XP_006517781.1

EC 2.4.2.30

XP_011242981.1

EC 2.4.2.30

XP_011242982.1

EC 2.4.2.30

XP_030103181.1

EC 2.4.2.30

XP_030103182.1

EC 2.4.2.30

XP_036013983.1

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081009.3 → NP_001074478.3 protein mono-ADP-ribosyltransferase PARP8 isoform 1

Status: VALIDATED

Source sequence(s)

AC154224, CT025610

Consensus CDS

CCDS36790.2

UniProtKB/TrEMBL

F8WIK2

Related

ENSMUSP00000152911.2, ENSMUST00000223949.2
NM_001427065.1 → NP_001413994.1 protein mono-ADP-ribosyltransferase PARP8 isoform 2

Status: VALIDATED

Source sequence(s)

AC154224, CT025610

UniProtKB/Swiss-Prot

Q3UD82, Q3UDE4, Q3UDU5, Q8VCB5, Q9CYY3
NM_001427066.1 → NP_001413995.1 protein mono-ADP-ribosyltransferase PARP8 isoform 1

Status: VALIDATED

Source sequence(s)

AC154224, CT025610

UniProtKB/TrEMBL

F8WIK2
NM_001427067.1 → NP_001413996.1 protein mono-ADP-ribosyltransferase PARP8 isoform 2

Status: VALIDATED

Source sequence(s)

AC154224, CT025610

UniProtKB/Swiss-Prot

Q3UD82, Q3UDE4, Q3UDU5, Q8VCB5, Q9CYY3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

116987378..117162549 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158090.1 → XP_036013983.1 protein mono-ADP-ribosyltransferase PARP8 isoform X4

UniProtKB/TrEMBL

B2X2E0

Conserved Domains (1) summary

cd01341
Location:445 → 569

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_030247321.2 → XP_030103181.1 protein mono-ADP-ribosyltransferase PARP8 isoform X5

UniProtKB/TrEMBL

B2X2E0

Conserved Domains (1) summary

cd01341
Location:362 → 486

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_030247322.2 → XP_030103182.1 protein mono-ADP-ribosyltransferase PARP8 isoform X5

UniProtKB/TrEMBL

B2X2E0

Conserved Domains (1) summary

cd01341
Location:362 → 486

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_011244679.4 → XP_011242981.1 protein mono-ADP-ribosyltransferase PARP8 isoform X2

Conserved Domains (1) summary

cd01341
Location:771 → 895

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_006517718.5 → XP_006517781.1 protein mono-ADP-ribosyltransferase PARP8 isoform X1

Conserved Domains (1) summary

cd01341
Location:771 → 895

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_011244680.4 → XP_011242982.1 protein mono-ADP-ribosyltransferase PARP8 isoform X3

Conserved Domains (1) summary

cl00283
Location:559 → 608

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_027272.3: Suppressed sequence

Description

NM_027272.3: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: PARP8 (GeneID:79668).